151' 11 2012

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:KEY WORDS

.Inflammation; Cancer; NFB; Herbal medicine

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151' 11 2012

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NF-B B ,
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()Colorectal cancer

, [.]14,13
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NF- B
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,
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IB

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.
Pol yc yc l ic ,
hydrocarbons ,

NF-B

[ .]14,6 ,



.NF-kB ,
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(,)Human papillomavirus
,
; HIV

,

(),
;
.
;
B C ; NF-kB
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.

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l
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g
n
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[.]15
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B
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.

,
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[.]16
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NF-B

631

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() ,
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.
NF-B
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NF-B ,
[ .]17
NF-B
,
.

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() NF-kB DNA ,
,)Antisense RNA ( RNA
( ,)Proteasome inhibitors ,
[.]18
,
,NF-B
-
. ,
NSAIDs
(" ") . ,
,NSAIDs ( ,)Sulindac
( )Ibuprofen ( )Indomethacin
,NF-kB
( ) [.]19
NF-B
),)Bortezomib
( )Dexamethasone .
NF kB ,
()Docetaxel
[ ,]20
( )Melphalan [.]21


. ,
.NF-kB
, :
( :)Curcumin
3,500
, ,
. ,

, , ,
( .]22[ )Apoptosis ,
NF-kB
[ ,]23
,)COX-2( cyclooxygenase-2
, .
( :)Capsaicin ' ,
.
,

151' 11 2012

: , [ .]23
, ,
NFB .]24[ IB
:Diallyl disulfide (Allium
.)sativum ,
, ,
[ Diallyl disulfide .]25
, ,
NF-B (.]25[ )Down regulation
( :)Resveratrol ( )
,
.
,
. : , , , ,
,
( ,)Migration [.]26
.]26[ NF-kB
'' ( :)Gingerol '' (.)Ginger
'' ,

, .''
, .''
NF-B
,IB inducible
)iNOS( Nitric Oxide Synthase ,COX-2 NF-
B [.]27
Anethol ( )Dianethol
( :)Photoanethol ,
( )Fennel ).Pimpinella anisum L( Anise
, ,
() . ,
,
IkB
, .]28[ NF-kB
Eugenol :Isoeugenol
( .)Clove

,
.]29[ Eugenol
, Eugenol
, .]30[ NFkB
, , 2,500" :
" .
,
NF-kB
.
NF-kB
.

:
, ,
,6 64239
03-6947506 :
03-6925757 :
shaharl@tasmc.health.gov.il :

2012 11 ' 151

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