Cornus ()

..

 Cornus, Cornaceae
. , ,
. cornus ,
,
,

.
,
,
.

Plantae
Tracheobionta
Spermatophyta
Magnoliophyta -
Magnoliopsida

Rosidae

Cornales

Cornaceae

Cornus

, Cornus cornum
.
Cornus.

 Cornus, 30- 50 ,
, .
,
. Cornus, ,

.
, Cornus
Cornus mas L. , .

,
.
3 Cornus
.
cornus Chamaepericlymenum
Cornus canadensis,
.

CORNUS SUBGENUS

CORNUS

SWIDA

BENTHAMIDIA

Cornus alba
Cornus mas L.

(Swida alba)

Cornus florida

(European cornel)

Siberian dogwood

Cornus alternifolia
Cornus officinalis

( Swida alternifolia)

Cornus kousa

(Japanese cornel)

Pagoda dogwood

( Cornus chinensis)

, ,

, K .

Cornus controversa

Cornus nuttalii

(Swida controversa)

B ,
,

Cornus drummondii
(Swida drummondii)
,

Cornus sanguinea

Cornus stolonifera
(. Cornus sericea)
Red -osier dogwood

, ,
. .
, 8 ,

.
: , 4-10 cm
,
.
,
, 3-5 .
,6 cm.

,

6-10 x 3-6 m
. , . , 22,5 mm. , .
. .
, 12-15 mm, , ,
.
.

:
: European cornel, cornelian cherry,
golden glory dogwood
: cornouiller male

 :
1. o ,
2. ,
3.
4. .

, ,
,
, ,
ph 3,7 -7,5. ( ph
6.0 -7,0 ) 600 .
3x4 m,

( - 30 C ) ,

, .
, 15
2 .
-
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.

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. jolico ,
. pioneer ,
35 .

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Cornus florida

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, .
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ateria Medica 1827,
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(, , . , .
1993) . ,

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Cornus mas

,
.
Kirklareli ,
(
kran Kltr 2007) .
10

2 8
, .
2 10
, .

.


ejane ,
,

, ,
.
Eclectic Materia medica Felter 1922
Cornus specific medicine ,
Cornus florida 2-60
(Cinchona) , ,
, , , .
.

Cherokee

Cornus florida
Cornus alternifolia. , ,
Cornus alternifolia

. , Cornus alternifolia
, . ,
2 ,
, .

Cinchona,
.
.
.

11

cornus

.

.

Cornus

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( . pH) .
,
.( 2007). ,
.

12

Cornus mas
, (Nair, M.G. Olson 2006)
1)

3--

2)

3--

3)

3--

4)

3--

,

.

, ( C),
, . C
, 101-193 mg 100 gr ( Pantelidis et al. 2007 )

C, , (46mg / 100 gr)
(31 mg / 100 gr) (29-80 mg/ 100 gr) .

13

 Cornus
, ,
,
.

HPLC

Cornus

alternifolia ,Cornus kousa, Cornus controversa Cornus florida (Vareed et al.

2006) .
C.alternifolia, C.controversa : 1) 3-o-
2) 3--
3) 3--
C.kousa C.florida ,

1) 3--
2) 3--

Cornus

I.

Cornus mas L.
Cornus

.
,
. ichigan (Nair, M.G.Olson
2006) Cornus mas

in vitro. ,
, ,
,
4 10 mM . 3--
3--

. 3-
14


1,4 4 mM. O
.

Cornus mas
in vivo , o
. 4
,
8 .

, 24
%,
.

.



( Cornus mas L.)


,

,
.

II.

Cornus officinalis Sieb. et Zucc.

Cornus officinalis

(Zhongguo Zhong Yao Za Zhi 2001 )

.
GLUT4mRNA ,
,
15


.
Cornus officinalis

,
(Yamahara et al. 1981)

. Cornus officinalis Fructus corni,
2000
Shan zhu yu . To
.

,
.
1. DIE HUANG WAN
6
,

yin , .
yin ,
,
. :

Dioscorea rhizoma

12 gr

Corni fructus

12gr

Rhizoma alismatis

9 gr

Poria

9gr

Rehmnniae radix

24 gr

Moutan radicis cortex 9 gr

To
, , , , ,
, , , , ,

16

 .
, .
( Liou et al 2004) ,
( wistar)
.
6
. Cornus

.
Cornus ,

5
. Cornus officinalis
Die
Huang Wan.
( Qi et al. 2008)
Cornus officinalis ,
,
.
Cornus officinalis ( Su et al.2007)

2. SHEN QI
7
Cornus officinalis,

.
.
Panax ginseng (ginseng)
Radix astragalus (milkvetch root)
Dioscorea opposite ( comon yam rhizome)
17

Coptis chinensis ( coptis root )

Rehmannia glutinosa (chinese foxglove root)
Cornus officinalis ( asiatic cornelian cherry fruit)
Hirudo nipponia (leech)
To

(Yang
and Wang, 2000)

150

Ruzhou

,
,
-
.

III.

Cornus stolonifera

(Mc Cune et al. 2007 )

Cornus stolonifera

: , ,
. Cornus stolonifera
,

.
,

stress.

18

, ,

, ,
, .
, Cornus,
.
1. ,
, (TAC total
antioxidant capacity),

(Dragovi Uzelac 2007)
2. To Cornus officinalis
L .( Jeon et al
2008)
3. Cornus
mas, Cornus officinalis, Cornus kousa Cornus controversa, ( Seeram et al.
2002) .
,
. 1-3
4-7.

ANTIO
1

3--

70 %

3--

60 %

3--

40 %

83 %

79 %

82 %

10 %

19

Cornus

, , , ,
,
.
1-3 ,

4 Cornus

COX-I COX-II,
.

:
% COX-I

% COX-II

9.2

11,7

7,6

11

5,3

7,8

Naproxen

54

43

CELEBREX

46

66

IBUPROFEN

47

39

3-o-

3-o-

3-o-

1. , (Jeon et al. 2008 )

Cornus officinalis, 2
, 83 78%.
,
.
20

2.

cornus, 2006 ,( Vareed et al.

2006)

3--

3--

alternifolia, C.controversa, C.kousa C. florida

C.

50 %

, ,

, in vitro.
3. Cornus officinalis in vitro , ( Chang et al. 2004)

.
C.officinalis
, .

Cornus kousa

-
Cornus, ,

21


Cornus
, ,
.
Cornus officinalis
.
:

o Cornus officinalis
:
1.
2.
3.
.

. ,
. ,

22

,
( CPVO).
,
,
,
.

,
12 . ,
, , .
, .
.

.
(
) 2001
16 2008 80 . ,
10 ,
.
,

2000 .

.

.

.

23


Cornus
, ,
. ,
, , ,
, , ,
,
.

Cornus ,

,
.

Cornus alternifolia

24


1.Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro Chang, J.S., Chiang, L.-C., Hsu, F.-F., Lin, C.-C., 2004, American Journal of Chinese Medicine 32 (5), pp. 717-725
2.Antioxidant activity relates to plant part, life form and growing condition in some
diabetes remedies, Letitia M. McCunea,, Timothy Johns a,b, Journal of Ethnopharmacology 112
(2007) 461469
3.Natural medicines used in the traditional Chinese medical system for therapy of diabetes
mellitus,W.L. Li a,b, H.C. Zheng c, J. Bukuru b, N. De Kimpeb, Journal of Ethnopharmacology 92
(2004) 121
4.Antioxidant activity in medicinal plants associated with the symptoms of diabetes
mellitus used by the Indigenous Peoples of the North American boreal fores, Letitia M.
McCune a,*, Timothy Johns , Journal of Ethnopharmacology 82 (2002) 197_/205
5.Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory
compounds in Cornus kousa fruits, Shaiju K. Vareed1, Robert E. Schutzki, Muraleedharan G. Nair_,
Phytomedicine 14 (2007) 706709
6.Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida
fruits with health benefits, Shaiju K. Vareed, Muntha K. Reddy, Robert E. Schutzki, Muraleedharan
G. Nair , Life Sciences 78 (2006) 777 784
7.An herbal formula, Herbkines, enhances cytokines production from immune cells,SeungHeon Honga, Hyun-Ja Jeong b, Hwan-Suck Chungb, Hyung-Ryong Kimc,Han-Jung Chaed, Taekyun Shin
e, Youngwan Seo f, Hyung-Min Kimb, Journal of Ethnopharmacology 98 (2005) 149155
8.Ethnobotanical knowledge of the Istro-Romanians of Zejane in Croatia, Andrea Pieronia,e
Maria Elena Giustib, Harald Munzc,Cinzia Lenzarinib, Giuliana Turkovicd, Ana Turkovic, Fitoterapia 74
(2003) 710719
9.Physico-chemical and antioxidant properties of cornelian cherry fruits (Cornus mas L.)
grown in Turkey, Serpil Tural, Ilkay Koca , Scientia Horticulturae 116 (2008) 362366
10.Preliminary characterisation of cornelian cherry (Cornus mas L.) genotypes for their
physico-chemical properties, Kadir Ugurtan Yilmaz a, Sezai Ercisli b,*, Yasar Zengin a, Memnune
Sengul c, Ebru Yasa Kafkas, Food Chemistry 114 (2009) 408412
11.Antidiabetic Herbal Drugs Officially Approved in China, Wei Jia1*, Wenyuan Gao2 and
Lida Tang3, PHYTOTHERAPY RESEARCH 17, 11271134 (2003)
12.UPREGULATED ENDOTHELIN SYSTEM IN DIABETIC VASCULAR DYSFUNCTION AND
EARLY RETINOPATHY IS REVERSED BY CPU0213 AND TOTAL TRITERPENE ACIDS FROM
FRUCTUS CORNI, Wei Su, De-Zai Dai, Hao-Ran Liu, Tao Na and Yin Dai, Clinical and
Experimental Pharmacology and Physiology (2007) 34, 12281233
13.Ethnobotanical survey of Zagori (Epirus, Greece), a renowned
centre of folk medicine in the past, Despina Vokoua, Katerina Katradi and Stella Kokkini,

Journal of Ethnopharmacology, 39 ( 1993) I87- 196

14.Symptom-Specific Antioxidant Activity of Boreal Diabetes Treatments, Letitia M. McCune1

and Timothy Johns2, Pharmaceutical Biology, 2003, Vol. 41, No. 5, pp. 362370 Swets & Zeitlinger
15. Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in
Wistar rats, Shorong-Shii Liou, I-Min Liu, Sheng-Fa Hsu and Juei-Tang Cheng, JPP 2004, 56: 1443
1447
16.Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic
cardiomyopathy
by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocinrats, Min-You Qi, Hao-Ran Liu, De-Zai Dai, Na Li and Yin Dai, JPP 2008, 60: 16871694

25

17.Medicinal plants used in Krklareli Province (Turkey),S Sukran Kultur ,Journal of

Ethnopharmacology 111 (2007) 34136
18.Antioxidative, antimutagenic, and cytotoxic activities of ethanol extracts from cornus
officinalis Jeon, Y.H., Kim M.H., Kim, M.R , Journal of the Korean Society of Food Science and Nutrition
Vol 37, Issue I 2008 pages 1-7
19. Amelioration of obesity and glucose intolerance in high- fat fed C57BL/6 mice by
anthocyanins and ursolic acid in Cornelian cherry ( Cornus mas L.)
Jayaprakasam B.. Olson LK, Schutzki RE , Tai MH, Nair MG
J AGRIC. FOOD CHEM. 2006 Jan 11;54 (1) : 243-8
20. Study of the extraction ,purification and antidiabetic potential of ursolic acid from
Cornus officinalis Sieb. Et Zucc. Gao. D. , Li, N. , Li Q. , Li J., Han Z, Fan Y. ,Liu Z. Therapy vol. 5.
issue 5 septempber 2008, pages 697-705
21. Lignans from he fruits of Cornus kousa Burg. and their cytotoxic effects on human
cancer cell lines. Lee DY, Song MC, Yoo KH, Bang mh, Chung I.S, Kim S.H , Kim d.k, Kwon B.M,
Jeong T.S, Park M.H, Baek NI . Archives of Pharmacal Research Vol. 3 , issue 4, April 2007, pages 402407
22.
, 2006 2007 ,
.. , .
23. Florida Ethnobotany Daniel f. Austin- Narodny Honeychurch, dogwood dogtree (google books)
24.Dogwoods : the genus cornus Paul Capiello Don Shadow (google books)
24.The Eclectic Materia Medica- Pharmacology and Therapeutics 1922 by Harvey Wickes
Felter M.D
25. AGRENDA 9-10/5/2009 .15 .
. . - ...

http://en.wikipedia.org/wiki/Dogwood
http://en.wikipedia.org/wiki/Cornus_mas
http://vikos.bat.uoi.gr/plant.php?
USDA PLANTS DATABASE
Agronews.gr
http://www.raysahelian.com/cornus officinalis.html
http://phytologio.blogspot.com
www.wellness.com
http://www.healthline.com/natstandardcontent/dogwood/2
http://www.answers.com
http://www.mdidea.com/products/proper/proper013.html

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