Name of Drug Generic Name: Cefuroxime DRUG STUDY Dose: 500mg/tab

Classification of Drug Therapeutic: Anti-infectives

Mechanism of Action Bind to bacterial cell wall membrane, causing cell death

Indication Treatment of It is effective for the treatment of penicillinaseproducingNeisseria gonorrhoea(PPNG). Effectively treats bone and joint infections, bronchitis, meningitis, gonorrhea, otitis media, pharyngitis/tonsilliti s, sinusitis, lower respiratory tract infections, skin and soft tissue infections, urinary tract infections, and is used for surgical prophylaxis, reducing or eliminating infection.

Contraindications Hypersensitivity to cephalosporins and related antibiotics; pregnancy (category B), lactation.

Side Effects GI: Diarrhea, nausea, antibioticassociated colitis. Skin: Ra sh , pruritus, urticaria. Urogenital: Increased serum creatinine and BUN, decreased creatinine clearance. Hemat: Hemolytic anemia MISC: Anaphylaxis

Nursing Responsibilities Before:

Determine history

Pharmacologic: Second Therapeutic Effects: generation Bactericidal action Cephalosporins Pregnancy Catergory B

of hypersensitivity reacti ons to cephalosporins, penicillins, and history of allergies, particularly to drugs, before therapy is initiated.

Lab tests: Perform

culture and sensitivity tests before initiation of therapy and periodically during therapy if indicated. Therapy may be instituted pending test results. Monitor periodically BUN and creatinine clearance.

During:

Inspect IM and IV

injection sites frequently for signs of phlebitis.

Monitor for

manifestations of hypersensitivity (see