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Due to hypoxia, Vessel closure and other tissue damage resulting in inflammation
It enhance the release of angogenic growth factor (VEGF) followed by the regrowth of the targeted neoplastic tissues
Combination of photodynamic therapy (PDT) & anti-angiogenesis It was published that phase II clinical study demonstrate great promises for the combination of PDT (Visudyne) with antiVEGF-A therapy using humanized antibody fragments (Lucentis) Effective treating some early stage superficial cancers Not yet been extensively demonstrated in the clinic advanced cancer Combination of photodynamic therapy (PDT) & anti-angiogenesis