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BRONCHIAL ASTHMA IN ACUTE EXACERBATION PATHOPHYSIOLOGY SCHEMATIC DIAGRAM

Predisposing Factors Gender, Age, Family History, Race dander, dust, pollen, etc.)

Precipitating Factors Viral Respiratory Infections, Allergen Exposure (animal

Change in Weather, Smoking, Exercise

Exposure to different pathogens

Entry of the allergen

Release of immunoglobulin E (IgE)

Release of different chemical mediators

Mast cell degranulation

Release of the different inflammatory chemical mediators

Leukotrienes inflammatory mediators

Prostaglandins

Histamine, bradykinin, & other

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Release of eosinophils (to combat allergen)

Opening of the mucosal inrtracellular junction

Inflammatory process

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