ORAL DRUS COMMONLY USED IN TREATMENT OF HYPERTENSION

Drug class examples Usual total daily dose(dosing frequency/day) 6.25-50 mg (1-2) 40-80 mg (2-3) 25-100 mg (1-2) 25-100 mg (1-2) 25-200 mg(2) 25-100 mg (1-2) 30-60 mg (1) Potential adverse effects Hypokalemia,hype ruricemia Hypokalemia, hyperuricemmia Bronchospasm, bradycardia, heart block Cough,hypercalemi a,azotemia Hypercalemia, azotemia Edema, constipation Diuretik thiazides Loop diuretics Beta blockers hydrochlorothiazid e furosemide Atenolol propranolol captopril losartan nifedipine

ACE inhibitors Angiotensin II receptor blocker Calcium chanel antagonists

 BETA BLOCKER Particulary useful in young pts with hyperkinetic circulation. Relative contraindication: bronchospasm,bradykardia.

 ACE inhibitors and angiotensin II receptor blockers ACE inhibitors are well tolerated with low frequency of side effects. May be used as monotherapy or in combination with a diuretic,calcium antagonists or beta blocker.

 calcium antagonists Direct arteriolar vasodilators ; all have negative inotropic effects and should be used cautiously if LV dysfunction is present.