HEE G SUF U) Analysis Volume - 1 Lee 3 Dr. K. R. MAHADIK Dr. S. G.WADODKAR Dr. H. N. MORE x NIRALI PRAKASHANPHARMACEUTICAL ANALYSIS — | ISBN NO. 978 - 81 - 85790 ~ 07-7 Thirteenth Edition November 2007 Re-print Edition 2 June 2008 © : Authors ‘The text of licatior ‘thereot, Teproduced or transmi stored computer ‘system oxen datnaen nn coy, eet tan reveal Siva geen evevadanan an om ieadreiag Stier momabor sora device so wifou the wah end ieerarer ete are reserved. tis, e is forlegal action, stot has been made to avot eras a onions in ths pablealon In In. Any nistae, eror or degen) oe wis {our non wg sal be lan oo ein tenet eddon ls otled Va nei pte Nor Oe auihorsor ote ay damage tr tns ot nto one a Fad any ater dee Published Printed NIRALI PRAt ARIHANT PRIl nee ts NS sok Nagar, Pret Ne 4, Matt Yar, Gulia, inova Center, PUNE Tel (020 2106 80/4280 of FUNadh (Dicer Fax - (020) 25511379 DISTRIBUTION CENTERS PUNE MUHBAL Sicha Pat opeshwa Mad La 445, SNP. Road Rasch. tsp Sosy . ari Mandir Lane begre Pine ate Nanas Ging, Mumba 400008, Mararashra Tel : (020) 2445 2044, 66022708 Fax : (020) 2445 1538 ‘Tol : (022) 2985 6339 / 2386 0976, Fax : (022) 2586 $976 DISTRIBUTION BRANCHES NAGPUR JALGAON Pratibha Book Distributor Pragati Books Pvt. Ltd, Above Maratha Mane Shop No.3, Fist le, 34,V.V. Golan Ma, Na Pace (2000 Rani Zansti Square, Sitabuld, Nagpur 440012, Tel: (0257) 722 0395, Maharshi, Yl: (0712) 254 7428, Mob : 98222 01952 + 94234 91860 KOHLAPUR Poe naan Pragati Books Pvt. Ltd. 7 yan San Sora Fist Foor, Ravar Karan Ganesh Krupa, 2430-A, Gandhi Maidan oad, Near Guimohar Book Dapto, Shivaii Peth, Tel: (0253) 2506498, eb 94222 53538 Kohlapur 416 012, Maharashtra. Mob : 9860182678 BANGALORE Lucknow Pragati Book House ‘Shubham Book Distributors House No. 1,Sanjeevappa Lane, Avenue Read Cross, 88, Chander Nagar Market, Aambagh Opp. Rice Church, 560002. Lucknow Uttar Pradesh Tel : (080) 64513344, ted Tel : (0522) 245 3269 (Shop) / 245 5184 (Res.) Mob : 9880582331, 9845021552 Mob : 9895231322, Email: Shubhambooks @siy.com Emailbharatsavia@ yahoo.com a Nirall Book Praga eae Be Shyam sncave, 45947, Bad Chow 87, Monet Fn eatin fo aba Pradesh ‘Chennai, 600008 Tamil Nadu Tel: (04) 6554531, Me pus ‘94400 30608 Tel: sous Mob : 94440 01782 / 8450 21552 / Email: niralibooks @ yahoo, ‘98805 82331, Email: bharatsavia@ yahoo.com Pune {a Budar Pat Op. Ratan Takes S76, Btw Pb, Op peat sen Nand Pune 411002, hanseshin ' Pune 411002, Maharashtra Tel : (020) 2445 8887 / 6602 2707, Fax: (020) 2445 8887 Tel : (020) 6601 7784 / 6602 0855 Pragati Book Cantro Pragati Book Centre 152, Budhwar Peth, Pune 411002, Maharashtra 917/22, 8 eins F.C. Road, cre, Hotel i, Tel (20) 2445 2254 / 6€09 2463 Shiver, Pune 41004, (020) 2566 3372/6602 2728 Mumbai Pragati Book Comer Indira Niwas, 111 ~ A, Bhavani Shankar Road, Dadar (W) Mumbai 400028, Maharashtra. Tel : (022) 2422 3528 / 6862 5254 nail: pchombay @pragationline.com ‘wow pragationlinecom pragetibooks@vsoi.nel1L_INTRODUCTION TO PHARMACEUTICAL ANALYSI§. dL = 1B Chemical purity 11 Quantitative assays 15 Source of impurities 21 Effect of impurities 22 an id Limit test for sulphate 2.6 Limit test for iron 26 Limit test for heavy metals 2.6 Limit test for vol i Limit test for lead 28 Limit.test for arsenic 2.9 3._SOME FUNDAMENTAL CONCEPTS 0 = BD Saluti Fs 2 Volumetric methods. Steps in quantitative analysis 3.7 Standardisation 8 End point detection 39 Calibration of volumetric glasswares 3.10 4. SAMPLING TECHNIQUES 41 - 45 Sampling of gases AQ Sampling of liquids 42 Sampling of solids 43 Sampling of pharmaceuticals $4 Sampling of vegetable drugs 45 5._GRAVIMETRIC ANALYSIS 51 - 517 Conditions of precipitation 5.1 Colloidal state 5.3 Purity of precipitate 55 Gravimetric analysis-techniques SL