Generic / Brand Name Carboplatin / Paraplatin

Class and Action

Indications

Contraindications >Contraindicat ed with history of severe allergic reactions to carboplatin, cisplatin, platinum compounds, mannitol,; severe bone marrow depression; lactation >Use cautiously in renal impairment, pregnancy, history of neuropathic disorders.

Side Effects

Adverse Effects

Nursing Considerations

Class: *Alkylating drug *Antineoplastic Action: Cytotoxic: Heavy metal that produces cross-links within andbetween strands of preventing DNA, thus preventing cell replication; cell cycle nonspecific.

>Initial treatment of advanced ovarian carcinoma in combination with other antineoplastic >Palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy , including patients who have been treated with cisplastin. >Unlabeled use: Alone or with other agents to treat smallcell lung cancer, squamous cell

>Nausea and Vomiting >Numbness >Tingling >Loss of taste >Ringing in ears >Dizziness >Loss of hearing >Rash >Loss of hair

>Peripheral neuropathies, ototoxicity, visual disturbances, change in taste perception >Abdominal pain, diarrhea, constipation >Bone marrow depression, decreased serum sodium, magnesium, calcium, potassium >Anaphylactic-like reaction, uticaria, erythema, pruititus, bronchospam

>Evaluate bone marrow function before and during therapy. >Do not give next dose if bone marrow depression is marked. Consult physician for dosage.

cancer of te head and neck, endometrial cancer. Relapsed o refractory acute leukemia.