Tight junctions and cellular interaction

Transmembrane junctional proteins in the plasma membrane are clustered forming ridges of protein particles.
> Tight junctions forms a continuous belt around the apical ends of the

>Scaffolding at tight junctions recruit F-actin.

>Tight junctions contain transmembrane junctional proteins.

Tight junction and Blood-brain barrier

>Claudin, occludin, and junction adhesion molecules are clustered forming the tight junction.

>tight junction seal the adjacent endothelial cells.

>tight junction forms the blood-brain barrier which prevents the passage of substances.
>small ions and water molecules are not able to penetrate blood-brain barrier. >cells of immune system are able to pass across blood-brain barrier.

JOHN MARK PAREDES