NSAIDs

..

steroids

inflammatory drug(NSAID)

arachidonic acid

NSAIDs

cyclooxygenase (COX)

COX-2

COX-2

PGE2,PGI2

norepinephine vasopressin

PGF2a

NSAIDs

angiotensin
prostaglandins

II

prostaglandins

(1)

type

cyclooxygenase (COX1,2)

anti-

prostaglandins(PGs)

Non-steroidal

NSAIDs

NSAIDs

NSAIDs

5 mmHg

NSAIDs

(mean arterial pressure;MAP)

mmHg

(relative

(stroke)

45%

risk)

(1)

NSAIDs

calcium channel blockers

blockers,alpha-adrenergic blockers
blockers

NSAIDs

diuretics,beta-adrenergic

enzyme inhibitors (ACEI)

angiotensin converting

beta-adrenergic

(1,2)

meta-analysis

Indomethacin , Piroxicam

Naproxen

MAP

Naproxen

4.77 2.86

6.1

Indomethacin, Piroxicam

mmHg

Indomethacin Naproxen

mmHg

Piroxicam

Aspirin

Sulindac

3.6

3.7

Ibuprofen

Sulindac

Aspirin

(2)

selective COX-2 inhibotors

Celecoxib 2%

25 mg

50 mg

Rofecoxib

(2)

Aspirin

12.5

Rofecoxib

Ibuprofen

Naproxen

Sulindac

3.5%

selective

NSAIDs

8.2%

Indomethacin

COX-2 inhibotors

1. Gelman CR, Rumack BH & Hess AJ.(Eds): Drugdex

system. Micromedex, Inc., Engwood, Colorado. (volume
108:6/2001).

2. Brook RD,Kramer MB.Nonsteroidal anti-imflammatory

drugs and hypertension.J Clin Hypertens.[serial online].

2000 [cite2001 mar 27];2(5):[6screens].Avialable from:
URL:
http://www.medscape.com/LeJacq/JCH/2000/v02.n05/jch02
05.02broo/pnt-jch0205.02.broo.html.