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2 2
= a
y
x
tan
= Y y y y
n 1 2
= X
x x x
x x x
x x x
1
1
1
p
p
n n
p
n
1
2
1 1
2
2
2 2
2
=
p 0 1
y tn p s X XX X ( 1) ( )
0 0
1
0
= X x x x 1
p
0 0
2
0 0
= X
x x x
x x x
x x x
1
1
1
p
p
n n
p
n
1
2
1 1
2
2
2 2
2
=
=
s
y y
n
( )
2 i
i 2 0
2
+ y tn p s X XX X ( 1) 1 ( )
0 0
1
0
= X
N
x
1
i
i
=
=
s
n
x x ( )
1
1 i
1
2
1
2
= Std Err
s
x tv z
s
n
( , )
= logit ln
y
a y
= +
=
+ + +
Area y x x y y x x ( ) ( )( ) 0.5
i
i i i i i i i 1 1 1
= f z e
( )
1
bx
= + f z e c e
( ) ( )
1 1
bx dx
= =
SS SS
SS
( )
(9.2521 9.0477)
9.0477
0.02259
simple complex
complex
= =
DF DF
DF
( )
(42 40)
40
0.05
simple complex
complex
= = F
0.02259
0.05
0.4518
= m
false positivecost
false negative t
P
P cos
1
Sensitivity m Specificity (1 )
+ = = LR
obabilityofapositivetestgiventhepresenceofdisease
obabilityofapositivetestgiventheabsenceofdisease
Sensitivity
Specificity
Pr
Pr 1
= = LR
obabilityofanegativetestgiventhepresenceofdisease
obabilityofanegativetestgiventheabsenceofdisease
Sensitivity
Specificity
Pr
Pr
1
= + y y ax
0
= + + y y ax bx
0
2
= +
( )
y min
max min
1
x
EC50
Hillslope
= +
+
y min
max min ( )
1
x
x
Hillslope 5
b
= x EC 10
b
Hillslope
log
50
1
2 1
s ( )
1
= +
+ +
y min
max min
f f
( )
( ) 1 1
X
x
EC
Slope
x
x
EC
Slope
50
1
50
2
= >
=
+
=
+
Slope Slope SlopeCon SlopeCon
fx
C
Slope Slope
Slope Slope
, 0
1
1
2 2
x
EC
C
f
2 1
1
1 2
f
50
= + + + + y b b x b d b d
k k 0 1 2 1 1 1
=
dy
dt
ay
1
1
=
+
+
f x
a bx
cx
( )
1
to arcsin -
2 2
to arctan -
2 2
=
=
x
n
x
1
i
n
i
1
=
n
r
n
r
( )
!
!(n-r)!
= erf x e dt ( )
2
.
x
t
2
=
=
erf x erf x
e dt
( ) 1 ( )
2
.
x
t
2
=
=
x
n
x
1
i
n
i
1
numerator
divisor
window ( 1)
2
+ + 1 2
3
(3 1)
2
+ + 1 2 3
3
= s
n
x x ( )
1
1 i
n
i
1
2
1
2
s
n
+ y
range
4
r
min
+ y
range
4
r
min
+ y
range
2
r
min
+ y
range
2
r
min
+ y
range
4
r
min
3
+ y
range
4
r
min
3
=
=
SS w y y ( )
i
i i 2
2
= CV standard error parametervalue 100/
= dependence
varianceof theparameter otherparametersconstant
varianceof theparameter otherparameterschanging
1
,
,
= c gradF Cov gradF ( ) ( )
T
=
= +
ConfidenceBand y x c M S CriticalT conflevels DF
Prediction Band y x c M S CriticalT conflevels DF
( ) ( . % , )
( ) 1 ( . % , )
res
res
= t
regression coefficient
standard errorof regression coefficient
= =
sum of squaresdueto regression
regression degreesof freedom
SS
DF
M S
res
res
res
= =
residualsum of squares
residualdegreesof freedom
SS
DF
M S
res
res
res
= =
regression variation from thedependentvariablemean
residualvariation abouttheregression
M S
M S
F
reg
res
= +
+ +
=
+
=
+
y min
max min
f f
f
C
Slope Slope
Slope Slope
( ) 1 10 1 10
1
1 10
2* *
Slope log EC x
x
Slope log EC x
x
C log EC x
f
10
( 50 ) ( 40 )
( 50 )
1 2
1 2
F
1 2
=
+
+ + + +
+
f x
x
x x x x exp
x
x
( )
( , )
2 1
3 2 4
2
2 6 7
2
2 2
1
8 9
2
2
= + +
+ +
+ +
y b b cos x b sin x
b cos x b b sin x b
b cos x b b sin x b
( ) ( )
( ) ( )
(2 /12) (2 /12)
2 / 2 /
2 / 2 /
1 2 3
5 4 6 4
8 7 9 7
+ +
= + +
+ +
a x b x c if x y isin data set
y a x b x c if x y isin data set
a x b x c if x y isin data set
1* 1* 1 ( , ) 21
1* 2* 2 ( , ) 2
1* 3* 3 ( , ) 2
2
2
2