*

Dr Susan Baker

* Cerebral Perfusion pressure * MAP ICP * 90 10 = 80 mmHg

* Any increase in volume of the contents within

the brain must be met with a decrease in the other cranial contents

Vintracranial
Venous Blood

vault=

Vbrain(85%)+Vblood(5%) +Vcsf(10%)
Arterial Blood Brain CSF

Venous Blood

Arterial Blood

Brain

Mass

CSF

Arterial Blood

Brain

Mass

Global Ischaemia

Intracranial Pressure (mmHg)

Focal Ischaemia Compensation

Intracranial Volume

* Cerebral Blood Flow

* 50ml/100g/min

* White Matter
* 20ml/100g/min

* Grey Matter
* 70ml/100g/min

* Total
* 750ml/min (brain approx 1500g)

Internal Carotid Arteries

Middle cerebral artery

Anterior communicating artery

Anterior cerebral artery Opthalmic artery

Posterior communicating artery

Internal carotid artery

*
Posterior cerebral artery Superior cerebellar artery Basilar artery

Pontine arteries

Anterior inferior cerebellar artery

Vertebral artery Anterior spinal artery

Posterior inferior cerebellar artery

Superior Saggital Sinus Falx Cerebri Inferior saggital sinus

Straight Sinus Transvers e Sinus Sigmoid Sinus

Internal Jugular Vein

* Volume of CSF * 100 150 ml * Rate of Production * 500 ml/day

Choroid plexuses

*
Monro Aquaduct of Sylvius Luschkae and Magendie

* Mechanical protection
1.4Kg to 47g

* Low specific gravity reduces weight of brain from * Constant for neuronal activity * Central Chemo-receptors * Monro-Kellie

* Chemical environment * Control of Respiration

* Regulation of ICP

Na+ K+

Ca2
+

Glucose

Cl-

HCO3-

Osmolality

PCO
2

pH

WCC
(per mm3)

Protei n

(mmol/l)
CSF Plasm a 140 3 145 4. 6 1.2 2.5 4 6-8 12 0 10 0 23 23

(mOsmol /kgH2O)

(KPa)

(g/l)
0.3 70

290 290

6.6 5.3

7.3 2 7.4

0-5 4-11 x 103

Cerebral Blood Flow (ml/100g/min)