FISH

specifity sensitivity FISH .

) 666
Mbp 866).
. FISH
.1 ( )M FISH .
.2 ( )I FISH

.
.
Inheritance of Gene Copy

: Single copy gene .1

.
: Multiple gene copy .2
Gene family .3
.
erb-2 .
GCH Comparative Genome Hybridization
.
(
)...
CGH

 . DNA
(
) .
.
. insertion deletion
. .
.
.
.

. :
Independent assortment of chromosomes .1
( 2n ) .
(
. ) 21 *21= 4 23
(. )223* 223
.2
Random fertilization .3

.
Gene & Environment
.
... . CpG
.

. X
.
. II .
miRNA ( .

 miRNA 3-5 LDL

).

:
: DNA mRNA
.
3.3*169 . 3.1*169 .
% 3-5 .
( junk ) . 36666 .
1566 .
.
Independently replication Alive
4666-5666 Ecoli .
%36 . ...!!!
: c
()... .
( %95-97 )
( )forensic medicine .
. .
2 (
). RNA miRNA
:

 RNA Pol
.
RNA Pol
:

RNA DNA : RNA (site)

DNA ( seat ) . DNA DNA RNA

 in vivo . in vitro RNA (

" " ) ( )PCR
( DNA ) .
. :
:
Initiation .1
Elongation .2
Termination .3

... GATA box TATA box ( )

. 6 -16
foot printing .

.
( )copy number
.
. .
.

. . (. G pro
)
.
RNA Pol
( %3

) .
.
RNA Pol .

RNA Pol
mRNA hairpin RNA Pol.
terminator signals DNA :
Two Types:
hairpin mRNA

1. Rho-Independent or Factor Independent :

2. Rho-Dependent

26 .
TATA DNA
.