Amanuel Negussie DOS 531 Week III

Breast TD5/5: Tissue dose associated with 5% injury rate within 5 years1 Breast (adult): 6000cGy [Atrophy] Lung [Pneumonitis] o 1/3 of the Lung: 4500cGy o 2/3 of the Lung: 3000cGy o The whole Lung: 1750cGy Heart: 4000cGy [Pericarditis and Pancarditis] Brachial plexus: 6000cGy [Clinically apparent nerve damage]

Pancreas TD5/5: Tissue dose associated with 5% injury rate within 5 years1 Liver: 3000cGy [Acute and chronic hepatitis] Kidney: 2300cGy [Nephritis] Stomach: 5500cGy [Ulceration/perforation] Small bowel: 4500cGy [Obstruction/perforation] Spinal cord: 4700cGy [Myelitis/necrosis]

Bilary Tract TD5/5: Tissue dose associated with 5% injury rate within 5 years1,2 Liver: 3000cGy [Acute and chronic hepatitis] Stomach: 5500cGy [Ulceration/perforation] Small bowel: 4500cGy [Obstruction/perforation]

Liver TD5/5: Tissue dose associated with 5% injury rate within 5 years1,2 Stomach: 550cGy [Ulceration/perforation] Small bowel: 5500cGy [Obstruction/perforation] Bilary duct: 3000cGy [Bilary fibrosis] References 1. Washington CM, Leaver D. Principles and Practice of Radiation Therapy. 3rd ed. St. Louis, MO: Mosby-Elsevier; 2010 2. Clifford C, Perez C, Brady LW. Radiation Oncology Management Decisions. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins;2011.