Distribution

Elimination



IV

Ra=Re

A<E

Bioavailability (F)
Site of administration
Blood

F 2

Absolute BA: AUCIV

Relative bioavailability: -IV
* Dose

First-pass effect
1st pass Met

1st pass effect

PB >>FD >>VD >>CL

DI PB90%

LD=Vd*Conc

Vd>>>>

tiss

CYP2D6

Clopidrogel CYP2C19

Sulfa,Chroram,Birilubin

Irinotecan
INH

Warfarin 2C9,TCA2D6

Benzyl alc

Para
Alc,methanol

CYP3A4,2C9,1A2
Variable:2D6

Enzyme induce(3A4);CBZ,Rif,NPV
Enzyme inhibitor(3A4);Itra,Keto,Erytho,PI

INH met phase II>>>I

Lorazepam phaseII

 enz

 PB

DI,Alb ,Mal

Enz (DI,)

rate

rate Conc

Pharmacokinetic
Enz

Dose
AUCDose
Autoinducer

SS~3-5t1/2
CL~3-5t1/2
LD=Vd*conc
MD=

Slope=logC1-logC2
t1-t2
-Ke=lnc1-lnc2
t1-t2

IV single dose: Dose >> Cp

Cl=Vd*ke

C0 Vd [Dose=Vd*Conc]

Slope Ke

IV continuous Css= Ko

Vd*Ke
MD