(t)

First order transfer function RC circuit

(t)

First order transfer function membrane RC Circuit

(t)

Second order transfer function

Second order RC circuit modeling the affected neuronal population. The activated synapse induced by tDCS results in excitatory postsynaptic current and excitatory postsynaptic potential at the cell body causing alterations in the membrane potential. This synaptic transmembrane current u(t) is a major contributor of the extracellular signal that can be measured with current source density analysis.

f = Cerebral blood flow (CBF) normalized by its baseline value