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The following are considered as phase 1 reactions in xenobiotics metabolism: a) Hydroxylation and dealogenation b) Dehalogenation and ulfation c) Sulfation and Hydroxylation d) Deamination and aceylation e) Acetylation and dehalogenation 2. The following are considered as phase 2 reactions in xenobiotics metabolism: a) Conjugation with bilirubin b) Conjugation with glutathione c) Methylation with S-adenosyl methionine d) Reduction e) B, C and D are correct

3. The following are known actions of cytochrome P450: a) Hydroxylation of foreign hydrophobic compounds in the liver b) Synthesis of steroid hormones in the adrenal cortex c) Conversion of procarcinogens into active carcinogens d) Inactivation of some drugs e) All of the above is correct 4. Characteristics of cytochrome P450 enzymes include: a) They are polymorphic hemoproteins b) They are mainly found in liver and intestine c) They have overlapping substrate specifities d) They are rich in phosphatidylcholine (lecithin) e) All of the above is correct 5. All of the following is correct about xenobiotics metabolism, except: a) It requires NADPH as a proton donor in hydroxylation reactions b) It renders non-polar chemicals more water soluble c) It may occur in the cytochromes of the electron transport chain d) It may affect drug action in the human body e) It is affected by genetic constitution of an individual 6. The following is correct about phase 2 reactions in xenobiotics metabolism? a) They intend to promote excretion of the xenobiotics b) They involve conjugation with glucuronic acid c) They involve methylation of xenobiotics with S-adenosylmethionine d) The acetyl transferase is the main enzyme in phase 2 reactions e) D is the only wrong statement 7. The following is incorrect about cytochrome P450 enzymes a) There are at least 30 different isoforms of these enzymes b) They may convert inert procarcinogens into active carcinogens c) They are essential for the activation of various drugs d) Their activity is affected by age and sex e) They are characterized by genetic differences