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  • Perfusion Weighted MRI of Intra-Axial Brain Tumours: Correlation With Histopathology

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    Shashank Sood
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    This study evaluated the use of advanced MRI techniques like diffusion and perfusion weighted imaging to determine the grade of 40 intra-axial brain tumors, compared to histopathology. Perfusion weighted imaging showed a sensitivity of 82.6% and accuracy of 80.65% in determining tumor grade, higher than diffusion weighted imaging which had a sensitivity of 69.57% and accuracy of 70.97%. The study aims to determine if these advanced techniques can more accurately assess tumor grade than conventional contrast enhanced MRI alone.

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    perfusion mri brain tumors

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    137-09

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    This study evaluated the use of advanced MRI techniques like diffusion and perfusion weighted imaging to determine the grade of 40 intra-axial brain tumors, compared to histopathology. Perfusion weighted imaging showed a sensitivity of 82.6% and accuracy of 80.65% in determining tumor grade, higher than diffusion weighted imaging which had a sensitivity of 69.57% and accuracy of 70.97%. The study aims to determine if these advanced techniques can more accurately assess tumor grade than conventional contrast enhanced MRI alone.

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    6 views1 page

    Perfusion Weighted MRI of Intra-Axial Brain Tumours: Correlation With Histopathology

    Uploaded by

    Shashank Sood
    This study evaluated the use of advanced MRI techniques like diffusion and perfusion weighted imaging to determine the grade of 40 intra-axial brain tumors, compared to histopathology. Perfusion weighted imaging showed a sensitivity of 82.6% and accuracy of 80.65% in determining tumor grade, higher than diffusion weighted imaging which had a sensitivity of 69.57% and accuracy of 70.97%. The study aims to determine if these advanced techniques can more accurately assess tumor grade than conventional contrast enhanced MRI alone.

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    Attribution Non-Commercial (BY-NC)
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    Perfusion Weighted MRI of Intra-axial Brain Tumours: Correlation with Histopathology

    Yawar Shoaib Ali, A. U. Ramzan


    Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Soura, J&K, India

    ABSTRACT BACKGROUND: Contrast enhancement on MRI has long being used as a marker for high grade among brain tumours. However, enhancement is a marker of blood brain barrier disruption and may not be an accurate measure of grade. We have used advanced MRI techniques like diffusion and perfusion weighted MRI for the pre-op assessment of brain tumour grade. OBJECTIVE: To determine the sensitivity, specificity and predictive value of diffusion and perfusion weighted MRI in determining grade of brain tumours. METHOD: A total of 40 intra-axial brain tumours were included in the study. All the patients underwent conventional MRI and were also evaluated by diffusion and perfusion weighted MRI. After surgery or stereotactic biopsy, the histopathological grade was determined as per the WHO 2007 classification of brain tumours. The pathologist was blinded to the results of the MRI. The sensitivity, specificity,predictive values and accuracy of the advanced MRI techniques in predicting tumour grade were determined. The statistical analysis was done by SPSS and Receiver Operator Characteristic(ROC) curves. RESULTS: The sensitivity of Diffusion Weighted Imaging for determining brain tumour grade was 69.57%, the specificity was 75%, the positive and negative predictive values were 88.8% and 46.15% respectively. The overall accuracy was 70.97%. The overall sensitivity of Perfusion Weighted Imaging was 82.6%, specificity was 75%, the positive predictive value was 90.48% and the negative predictive value was 60%. The overall accuracy was 80.65%.

    Key words: Diffusion, perfusion, MRI

    Journal of Medical Sciences 2013;16(Suppl 1):

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