SCHEMATIC DIAGRAM OF ALCOHOLIC CIRRHOSIS

Predisposing Factors: -Heredity -Metabolic disorders (Iron overload, Glycogen storage disease, Wilsons disease) -Underlying condition (Hepatitis, fatty liver, liver tumor, etc.) -Females are more prone than males but reports have higher cases in males Highly civilized countries Precipitating Factors: -Alcoholic (long term ingestion of at least 80g/day of ethanol) Female: 20g/day Male: 40g/day -Poor diet -Diet high in fat/ low in protein -Obesity

Increased liver synthesis of triglycerides & fatty acids, reduction in oxidation of fatty acids, and decreased release of lipoprotein

Fat accumulation in the parenchymal cells of liver and distention of cytoplasm with fats

Liver Steatosis/ Fatty Liver

Hepatocytes degenerate and become infiltrated with leukocytes and lymphocytes, lymphocytes, now called called as Mallorys Bodies or alcoholic hyalin

Mallorys bodies may result to fibrosis of its surrounding cells and veins

Inflammation of the Liver (Hepatitis)

Alcoholic hyalin leads to a hardened hyaline by which necrosis may occur

Progressive hepatocyte destruction leads to early scar formation and further damage to liver parenchyma

Liver capsule becomes firm and formation of regenerative nodules happens

. ALCOHOLIC CIRRHOSIS