Acute rheumatic fever 10-14 days after acute pharyngeal infection (because it's here that infection hangs

s around for a long time) Myocarditis Cardiac valvular disease Migratory arthritis and arthralgias Skin rashes CNS disease Fever Post streptococcal glomerulonephritis Can result from antecedent skin infection as well as pharyngitis Latent period of 5 days to 3 weeks Recurrences are rare, since only a limited group of M-types evoke the disease (especially type 12) Appears immunologic -- a cross reacting antibody directed against the stretococcal antigens, and/or the immune complex deposition of stretococcal antigen and antistreptococcal antibody S. viridans (group)

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