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Pham A Co Kinetic
Pham A Co Kinetic
Elimination
IV
Ra=Re
A<E
Bioavailability (F)
Site of administration
Blood
F 2
First-pass effect
1st pass Met
DI PB90%
LD=Vd*Conc
Vd>>>>
tiss
CYP2D6
Clopidrogel CYP2C19
Sulfa,Chroram,Birilubin
Irinotecan
INH
Warfarin 2C9,TCA2D6
Benzyl alc
Para
Alc,methanol
CYP3A4,2C9,1A2
Variable:2D6
Enzyme induce(3A4);CBZ,Rif,NPV
Enzyme inhibitor(3A4);Itra,Keto,Erytho,PI
enz
PB
DI,Alb ,Mal
Enz (DI,)
rate
rate Conc
Pharmacokinetic
Enz
Dose
AUCDose
Autoinducer
SS~3-5t1/2
CL~3-5t1/2
LD=Vd*conc
MD=
Slope=logC1-logC2
t1-t2
-Ke=lnc1-lnc2
t1-t2
Cl=Vd*ke
C0 Vd [Dose=Vd*Conc]
Slope Ke
IV continuous Css= Ko
Vd*Ke
MD