You are on page 1of 42

:

. . 1-

10 14%
.


-
.
25-50 3 1- - .

33%-
4% - .
50-70 :
70%-
10%-

3% - .

(
)

(50-80
- )

II


(
)


(-
)

(
,

)


()


()

( ,
.)

( ,
.)
/ \

:
1

4
5

6
5
(, ,)

.
.
.
.
. -

2
70-80%

4-7%


-
-

10-15%


(, , )

(L - 1, TNF), -2,
(NB -), TGF


()
I. (3-
)
1.1.
1.2.
1.3.
1.4.
1.5.
1.6.

II. (3
)
1.1.
1.2.

III. ( ,
)
IV.
1.1.

V.
1.1.
1.2.
1.3.

I.
II. ,
(
..)

II.
1.1.
1.2.
1.3.

III.
1.1.
1.2.
1.3.






.
(30
)







(,
)
(, )
1, 2 ()



()

( )


:
400

500

:
30, 60

:

,
() ,

3 .
(
) .


,
:




.



(,
):
,
. -
.


(
, )

.


(,


-1


90% - .
:
- 3-4
4-5

:
13%
25%
24 .
,
.

Glucosamine
hydrochloride

Glucosamine
sulfat

C6H13NO5xHCL
(215.63)

(C6H14NO5)2SO4x2NaCL)
(573.31)

, (%)

(99,1)

(80)

81,3

47,8

()

1500

2608

,
, (ESCISIT)

**

J. Y. Reginster
2001

,
- , 3

212

N.M. Thie
2001

,
- , 120

176

R. Ruane
2002

,
- , 12

218

L. Bucsi, G. Poor
1998


, 6

80

D. B. Uebelhart
1998

42

G. Verbruggen
1998

119

: :


..
..
..

, .

, 2004 .


..



.
-

, 2004 .

..


.
.

..

..,
. .

. . 4,
., 2004 .

-, 2005 11 25, 10-45-12-30, 622




:

The Glucosamine/chondroitin Arthritis Intervention Trial

(GAIT)

The Efficacy of Glucosamine and Chondroitin Sulfaye in patients with Painful Knee Osteoarthritis (OA) : The
Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)
Daniel O.Clegg, Donenic J. Reda, Crystal L.Harris, Marquerite A. Klain University of Utah, Salt Lake City, UT;
VASP, Hines, IL; VASP, Albuquerque, NM;NCCAM/NIH, Bethesda, MD
http://www.rheumatology.org./press/2005/clegg.asp

- :
40- 3238 . 125-400
(WOMAC- ), 6 , II-III . (Kellgren- ) .
: 1583 ,
1258 (80%) .
58,6 :
64% , 36%

10 .
59% - II ( Kellgren-)

:
125-300 WOMAC- ( 206 )
301-400 WOMAC- ( 341 )

The Efficacy of Glucosamine and Chondroitin Sulfaye in patients with Painful Knee Osteoarthritis (OA) : The
Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)
Daniel O.Clegg, Donenic J. Reda, Crystal L.Harris, Marquerite A. Klain University of Utah, Salt Lake City,
UT; VASP, Hines, IL; VASP, Albuquerque, NM; NCCAM/NIH, Bethesda, MD
http://www.rheumatology.org./press/2005/clegg.asp

:
, ,
:

()
(G) 500 3
(CS) 400 - 3
G (500 ) + CS (400 ) 3
() 200

The Efficacy of Glucosamine and Chondroitin Sulfaye in patients with Painful Knee Osteoarthritis (OA) : The
Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)
Daniel O.Clegg, Donenic J. Reda, Crystal L.Harris, Marquerite A. Klain University of Utah, Salt Lake City, UT;
VASP, Hines, IL; VASP, Albuquerque, NM; NCCAM/NIH, Bethesda, MD
http://www.rheumatology.org./press/2005/clegg.asp

(% ),
, 20% 24
(301-400
WOMAC)
-

80,0%

CS -

70,0%

G -

G+CS - +

69,40%

65,70%

60,0%
50,0%

79,20%

61,40%
54,30%

40,0%
30,0%
20,0%
10,0%
0,0%
P

CE

CS

G&CS

The Efficacy of Glucosamine and Chondroitin Sulfaye in patients with Painful Knee Osteoarthritis (OA) : The
Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)
Daniel O.Clegg, Donenic J. Reda, Crystal L.Harris, Marquerite A. Klain University of Utah, Salt Lake City, UT; VASP, Hines, IL; VASP,
Albuquerque, NM; NCCAM/NIH, Bethesda, MD http://www.rheumatology.org./press/2005/clegg.asp

:
-, (310-400)
,

.

The Efficacy of Glucosamine and Chondroitin Sulfaye in patients with Painful Knee Osteoarthritis (OA) : The
Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)
Daniel O.Clegg, Donenic J. Reda, Crystal L.Harris, Marquerite A. Klain University of Utah, Salt Lake City, UT;
VASP, Hines, IL; VASP, Albuquerque, NM; NCCAM/NIH, Bethesda, MD
http://www.rheumatology.org./press/2005/clegg.asp


:
200

250
- 100

:
60, 120


:

-


( ),

600-1200

80-90

- -

: (Garcia Rodriguez L. A., 1998)

( m).

11

1,0 0

2,3 0,5

3,5 0,5

3,5 1,2

4,8 0,5

6,0 0

10

7,0 0

11

8,0 0

10

9,0 0

10,3 0,5

-
I , .
II , .
III ,

-

I
II

III

, , , ,

, ,,

, ,

:
(1/2 = 2-8 ).!!!
,
( ,
).
,
,
.
.

3 , 1-2
.
2,1% (0,6-7,1%)

1 3
1


1
2


2 3

2- 8
5
6
7

()
1 3

1 2

()
2-3 0,5-1 .

- ,
.


:
1 -:

32


( )

( )


.
,

, ,

() +
(
)

1.
.
( ,
).
2. -
.

1.
2 .
3.

1. 1
2. 3 2

1.
2.

1. (
)

mpegi-30_dv2.mpg

You might also like