t

Cp

ln Cp
ln C residual

0
1
2
3
4
5
6
7
83
9
2
102.5
121 2
1401.5
0
16-1
1
18-2
240.5
-3
28 0
32
36
48

0
3.13
4.39
5.86
6.25
6.28
6.11
5.81
5.45
5.06
4.66
3.9
3.24
10
2.67
2.19
1.2
0.81
0.54 1
0.36
0.1

ln Cp

K eliminasi

Cp0

ln C ekstrapolasi
C ekstrapolasi
2.508

12.28

2.41

11.133

1.479329227

2.312

10.094

1.768149604

2.214

9.152

1.832581464

2.116

8.297

1.83736998

2.018

7.512

1.141033005

0.098

12.28

1.809926773
1.759580571

Chart Title

1.695615609

Chart Title

y = -0.0983x
+ 2.5082+ 2.2809
y = -0.1151x
R = 0.9983R = 1

1.621366483
1.539015448
1.360976553
20

1.17557333
30

0.982078472

Series1
40

50

60

Linear (Series1)
Series1

0.783901544

Linear (Series1)

0.182321557
t
-0.210721031
2

-0.616186139
t

-1.021651248
-2.302585093

C residual ln C residual

Ka

9.772 2.279521153

0.115

8.723 2.165963215

0.115

7.782 2.051813375

0.115

6.938 1.937013549

0.115

6.181 1.821480071

0.115

5.494 1.703656588

0.115

Cp

0
1
2
3
4
5
6
7
8
9
10
12
14
16
18
24
28
32
36
48

0
3.13
4.39
5.86
6.25
6.28
6.11
5.81
5.45
5.06
4.66
3.9
3.24
2.67
2.19
1.2
0.81
0.54
0.36
0.1

ln Cp

Keliminasi AUC'

AUCinf

Keliminasi*AUCinf

1.141033

0.097

1.565

1.565

0.151805

1.479329

0.097

3.76

5.325

0.516525

1.76815

0.097

5.125

10.45

1.01365

1.832581

0.097

6.055

16.505

1.600985

1.83737

0.097

6.265

22.77

2.20869

1.809927

0.097

6.195

28.965

2.809605

1.759581

0.097

5.96

34.925

3.387725

1.695616

0.097

5.63

40.555

3.933835

1.621366

0.097

5.255

45.81

4.44357

1.539015

0.097

4.86

50.67

4.91499

1.360977

0.097

8.56

59.23

5.74531

1.175573

0.097

7.14

66.37

6.43789

0.982078

0.097

5.91

72.28

7.01116

0.783902

0.097

4.86

77.14

7.48258

0.182322

0.097

10.17

87.31

8.46907

-0.21072

0.097

4.02

91.33

8.85901

-0.61619

0.097

2.7

94.03

9.12091

-1.02165

0.097

1.8

95.83

9.29551

-2.30259

0.097

2.76

98.59

9.56323

ab
Cp+(Keliminasi*AUCinf)

ab/ab'

1-(ab/ab') ln ((1-(ab/ab'))

3.281805 0.343169 0.656831

4.906525 0.513061 0.486939
6.873652.50.718758 0.281242

ln Cp

2
7.8509851.50.820955 0.179045
8.48869 10.887638 0.112362
0.5
0
10
20
-0.5 0

0
ln obat tidak diabsorbsi

0
-0.5

-1
-1.5
-2
1 -2.5 2
-3

-0.420328671

Chart
Title
-0.71961742

0.453

0.453

-1.720120161

0.453

-2.186032873

0.453

30

40

50

y = -0.0973x + 2.4775
R = 0.9971

0.453

-1.268540489

60

y = -0.4532x + 0.0966
R = 0.9939
5

-1
Series1
-1.5

Linear (Series1)

-2
-2.5

Series1
Linear (Series1)

Chart Title
3

Ka

near (Series1)