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Musculoskeletal Disorders

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Osteomyelitis

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Osteomyelitis
Severe infection of the

Bone Bone marrow Surrounding soft tissue

Caused by a variety of microorganisms


Most common infecting microorganism

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Etiology and Pathophysiology


Antibiotics in conjunction with surgical

treatments have decreased mortality rate and complications Infecting microorganisms can invade by

Indirect entry Direct entry

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Direct Entry
Can occur at any age Open wound where microorganisms can

gain entry to body May also occur in presence of foreign body



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Direct Entry
Sequestrum continues to be an infected

island of bone, surrounded by pus Difficult for blood-borne antibiotics or white blood cells (WBCs) to reach sequestrum Sequestrum can move out of bone and into soft tissue
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Direct Entry
Once outside bone Sequestrum may

Revascularize and then undergo removal by normal immune process Be surgically removed through debridement of necrotic bone

If necrotic sequestrum is not resolved, it may develop a sinus tract resulting in chronic, purulent cutaneous drainage
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Indirect Entry
Frequently affects growing bone in boys

<12 years old ---Why???

Most common sites of indirect entry

Distal femur Proximal tibia Humerus Radius

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Indirect Entry
Adults with increased risk Vascular disorders Genitourinary and respiratory infections Spread infection from blood to bone Vascular-rich bone sites

Pelvis Tibia Vertebrae


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Development of Osteomyelitis

Fig 64-1
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Clinical Manifestations
Acute Osteomyelitis

Initial infection
Infection

of <1 month in duration Both systemic and local

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Clinical Manifestations Acute Osteomyelitis


Systemic

Local Constant bone pain that worsens with activity Swelling, tenderness, warmth at infection site Restricted movement of affected part Later signs: drainage from sinus tracts
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Clinical Manifestations of Chronic Osteomyelitis


Chronic an infection that persists for longer than 1 month Infection that has failed to respond to initial course of antibiotic therapy Systemic signs ______

Signs and Symptoms Constant bone pain Swelling Tenderness Warmth at site Continuous Drainage

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Diagnostic Studies
Bone or soft tissue biopsy Definitive way to determine causative microorganism Patients blood and/or wound culture Frequently positive for presence of microorganism Lab Studies WBC Erythrocyte sedimentation rate (ESR)

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Radiologic Studies
Radiologic signs Usually do not appear until 10 days to weeks after start of clinical symptoms Radionuclide bone scans Helpful in diagnosis and usually positive in areas of infection Magnetic resonance imaging (MRI)

Computed tomography (CT) Help identify extent of infection, including soft tissue involvement
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Collaborative Care Acute Osteomyelitis


Vigorous and prolonged intravenous (IV)

antibiotic therapy

Treatment of choice for acute osteomyelitis As long bone ischemia has not occurred Cultures or bone biopsy should be done if possible

Delaying antibiotic treatment may require

surgical debridement and decompression


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Collaborative Care Acute Osteomyelitis


Patients are often discharged to home care

or skilled nursing facility (SNF) with IV antibiotics delivered via


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Collaborative Care Acute Osteomyelitis


Antibiotic therapy may be continued for

at home for _ to _ _____ or as long as _ __ _ ______ Variety of antibiotics may be prescribed


Penicillin, nafcillin (Nafcil) Neomycin, vancomycin Cephalexin (Keflex) Cefazolin (Ancef)


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Collaborative Care Chronic Osteomyelitis


Adults with chronic osteomyelitis may be

prescribed oral therapy + fluoroquinolone for 6 to 8 weeks instead of IV antibiotics Oral antibiotics may be given after acute IV therapy to ensure resolution of infection Monitoring patients response
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Nursing Care
Toxic effects: Aminoglycosides - Nephrotoxic, ototoxic, optic neuritis, fluid retention

Cephalosporins and Quinolones jaundice, colitis, photosensitivity, crystalluria

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Nursing Care/Patient Teaching


Measure

Preventive measures: Monitor _ _ _; Keep patient well hydrated to prevent ____________ or __________ Avoid direct sunlight, wear sunscreen Monitor urinary function, hearing, vision Assess for signs of yeast infections in genitourinary and mouth
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Collaborative Care Chronic Osteomyelitis


Surgical treatment for chronic

osteomyelitis

Removal of poorly vascularized tissue and dead bone Extended use of antibiotics Antibiotic-impregnated polymethyl methacrylate bead chains may also be implanted
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Collaborative Care Chronic Osteomyelitis


After debridement, wound may be closed

and a suction irrigation system inserted Intermittent or constant irrigation of affected bone with antibiotics Protection on limb or surgical site with casts or braces Negative pressure to draw wound together
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Collaborative Care Chronic Osteomyelitis


Hyperbaric oxygen therapy with 100%

oxygen as adjunct therapy

Stimulate circulation and healing

Orthopedic prosthetic devices, if source of

infection must be removed Muscle flaps, skin grafting provide wound coverage over dead space (cavity) in bone
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Collaborative Care Chronic Osteomyelitis


Bone grafts may help restore blood flow
Amputation may be indicated if

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Collaborative Care

Long-term and mostly rare complications


Septicemia Septic arthritis Pathologic fractures Amyloidosis

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Nursing Assessment
Important health information

Past health history

Bone trauma, open fracture, open or puncture wounds, other infections

Medications Surgery or other treatments


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Nursing Assessment
Subjective data

IV drug use, malaise Anorexia, weight loss, chills Weakness, paralysis, muscle spasms Local tenderness over affected area, increase in pain in affected area
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Nursing Assessment
Objective data General: Restlessness, high, spiking temperature, night sweats Integumentary: Diaphoresis, erythema, warmth, edema at infected bone Musculoskeletal: Restricted movement, wound drainage, spontaneous fractures

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Nursing Diagnoses
Acute pain

RT Inflammatory process secondary to infection AEB Guarding, moaning, crying, restlessness, altered muscle tone, decreased activity; Statement of pain

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Nursing Diagnoses
Impaired physical mobility RT Pain, immobilization devices, weightbearing limitations AEB Inability or unwillingness to change positions

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Nursing Diagnoses
Ineffective therapeutic regimen

management

RT Lack of knowledge regarding long-term management of osteomyelitis AEB Verbalization of concern and uncertainty about procedures and skills needed for home care
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Other Nursing Diagnosis Labels

Fear, Anxiety Powerlessness, Hopelessness

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Planning
Overall goals

Have satisfactory pain and fever control Not experience any complications associated with osteomyelitis Cooperate with treatment plan Maintain a positive outlook on outcome of disease
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Nursing Implementation
Health promotion

Control infections already in body Susceptible adults


Instruct susceptible adults and their families on local and systemic manifestations
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Nursing Implementation
Acute intervention

Immobilization and non-weight bearing on affected limb will decrease pain Limb should be handled carefully to avoid excessive manipulation and decrease pain Manage patients pain level using pharmacologic and non-pharmacologic strategies
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Nursing Implementation
Acute intervention (contd)

Patient is frequently on bed rest in early stages of acute infection

Good body alignment and frequent position changes prevent complications associated with immobility and promote comfort

Flexion contracture is a common sequela of osteomyelitis


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Nursing Implementation
Acute intervention (contd) Patient frequently positions affected extremity in a flexed position to promote comfort Contracture may then progress to deformity ___ ____ can develop quickly in lower extremity if foot is not supported in a neutral position by a splint or if there is excessive pressure from a splint
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Nursing Implementation
Acute intervention (contd) Instruct patient to avoid activities that increase circulation and swelling and serve as stimuli to spread infection

Exercise, ____ application

Dressings to absorb exudate from draining wounds


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Nursing Implementation
Acute intervention (contd)

Teach patient potential adverse and toxic reactions with prolonged and high-dose antibiotic therapy Lengthy antibiotic therapy can result in an overgrowth of

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Nursing Implementation
Acute intervention (contd)

Patient and family often frightened and discouraged Continued psychologic and emotional support is an integral part of nursing management

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Nursing Implementation
Ambulatory and home care

IV antibiotics can be administered to patient in a skilled nursing facility or home setting If at home

Patient and family must be instructed on correct care and management of venous access device Must also be taught how to administer antibiotic

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Nursing Implementation
Ambulatory and home care Importance of continuing antibiotics after symptoms have subsided should be stressed Periodic nursing visits provide support and decrease anxiety Frequent dressing changes for open wounds May require supplies and instruction in technique
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