Prof.

Roofs Virology DNA Viruses - Poxviridae Poxviridae

Pox-in-a-box wit ! straig t s"rings # linear dsDNA $a"e on er ba%& 'li&e (er%ulues ad) # envelo"ed virus * e Pox-in-a-box as a %ir%le ead and triangle body t at gives it a du+bbell a""earan%e ,or&s out wit du+bbells so it is big # -argest DNA virus Also. alt oug it is t e largest. it %auses t e s+all t ings # s+all"ox /t is large and s+all0 * at is %o+"li%ated1 # %o+"lex +or" ology 2ox # 2ri%& s a"ed DNA usually re"li%ates in nu%leus 're"resented by box). but Pox is "o""ing out into t e %yto"las+ # re"li%ates in %yto"las+ *ongue sti%&ing out # res"iratory s"read * e yellow 3V4 in t e box "lus Pox 5u+"ing out and saying 3 ola1 # Variola is anot er na+e for "oxviridae 'Varioloa +eans s"otted "i+"les in -atin)

Prof. Roofs Virology DNA Viruses - Poxviridae Pox in t e box starts inside t e box 'body trun&) and "o"s out 'extre+eties) # ras starts on body trun& and "rogresses to extre+ities to w ere it is found 'ras trun& 6 extre+ities) $entri7ugal ras in 8+all "ox vs. $entriPetal in $ i%&en "ox9 Re+e+ber 7ugal and 7ar 'extre+ities) $ i%&ens run all over t e "la%e # $ i%&en Pox is asyn% ronous 'ras at different stages) and 8+all "ox is syn% ronous ras 'all at sa+e stage) :irl is aving a fig t;war wit t e Pox in t e box # 2iowarfare < :uarnieri bodies 'first "art of :uarnieri souns li&e 3war= 3guar) # /ntra%yto"las+i% eosino" ili% bodies in e"it eliu+ be%ause Pox is in %yto"las+ 8 e is not a (aPPy son # * ese bodies are %alled >ollus%u+ bodies or (enderson-Peterson bodies * e little girl is alive. but wea&ened fro+ t e s%are of Pox in t e box # live attenuated va%%ine 'low yield. but na+ed va%%inia and not ad+istered any+ore sin%e eli+inated fro+ "o"ulation worldwide) * e s ell of a +ollus& is "early w ite wit a ole in t e to" # >ollus%u+ %ontagiosu+ w; "early w ite u+bili%ated lesions , ite % eese in +ollus& s ell # %aseous "lugs in lesions '%aseous +eans % eese-li&e) * e girl "uts er ands and feet u" in t e air and s%rea+s as Pox 5u+"s out # lesions lo%ated near ands. feet and +out 8 e tou% es Pox in t e box to fig t;war wit i+ # dire%t %onta%t s"read 'sexual or fo+ites) $o++on in young at letes ?nly u+ans "lay wit "ox-in-a-box # disease only in u+ans 'no ani+als) No treat+ent for ealt y < /++uno%o+"ro+ised get Ritonavir;$idofavir