Vancomycin - Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria.

Due to
the different mechanism by which Gram-negative bacteria produce their cell walls and the various factors related to entering the outer membrane of Gram-negative organisms, vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). Chloramphenicol - Chloramphenicol is a bacteriostatic drug that stops bacterial growth by inhibiting protein synthesis. Chloramphenicol prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. Peniccilin G - inhibiting the formation of peptidoglycan cross links in the bacterial cell wall. The beta-lactam
moiety of penicillin binds to the enzyme(transpeptidase) that links the peptidoglycan molecules in bacteria, and this weakens the cell wall of the bacterium when it multiplies

Erythromycin - a specific inhibitor of protein biosynthesis, inhibited the incorporation of phenylalanine by a

cell-free ribosomal system prepared from Escherichia coli. Vancomycin - It has activityagainst Gram-positive rods and cocci, Gram-negative rods are resistant to its bactericidal action.

Cefoxitin disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. Nitrofurantoin The mechanism of action of nitrofurantoin is unique and complex. The drug works by [5] damaging bacterial DNA, since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins (nitrofuran reductase) to multiple [8] reactive intermediates that attack ribosomal proteins, DNA, respiration, pyruvate metabolism and other macromolecules within the cell. Oxacillin - The mechanism of action of nitrofurantoin is unique and complex. The drug works by damaging [5] bacterial DNA, since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins (nitrofuran reductase) to multiple reactive [8] intermediates that attack ribosomal proteins, DNA, respiration, pyruvate metabolism and other macromolecules within the cell.