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معجزة الهرمون
معجزة الهرمون
14 MM
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119
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126
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ka GKCdG g qEa bGdG h .Ie fhdEG Ge hCG
G g IOLG LddG GG g Y dG qC
fL EG ,fhdEGh JG Jee N j
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qCG q J dh .eG OJh JG ebE JG G e
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138
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139
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G IOLG fCG b f j jdG T dG Gg qC Sa EG
.jdG EG SdG e c aVEH
dP Y eh ,JhdGh jG e jdG b e YO j dG g qEG
cCG q dG a ,G jL Gk QNG YJ dGh GTP `H IG jG
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NGO eGh FSq dG f Y kq e Gk AL J IQcG dG g qEG
Jhd AH IQTEG fc e J gCGh ,fCG SGH J q H ch ,q G
NGO Jd FSh iS d JhdG g CG kY dG hd RHjdG
141
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eg
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H j b GE G J eC G OHh
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H J GG gh ,a SdG SH
G JG FSh hGC jG cGq d
SH JG Sh
jHdG dG f
cG Y G j edG
bf jL
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Sar
fd dG JG Sh
142
YRe Fc IQTEG
bdG jL Y
j hQg
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Gh dG eg
S e T Y
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143
edG I`e
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FG P JhH e dCJ FSdG g e jN JG Sh q a ,gq dG e GaCG Za
dG Gdh ,jNCG JT TCG Y G OHCG KK T e dh ,eCG M
N f j eG qCG CG ,a JGf e J CG JhdG g J GdH
d Gb a ,G YGPEG dG e d bdG JhdGh eG f M G
.G YGPEG GOOdG J
144
edG I`e
dG JhdG e J dG AGLC G GE
J G NGO JG Gb e dC J
c GE Lj Ggh .H e kH ee
g ch OHC G KK JhdG jL
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,H e H eJ
146
j hQg
.SG SH2 JG Sh e
.SG a SH3 JG Sh e
gh ,e cGJ Y ebCG H j G JG f EG
,G IGf UN L EG G e FdG FSdG f e cGdG
S Y OLe GdH O AL EG dSdG g jEH J cGdG g qCG CG
GHh ,V YS U e Ae j eG e Fg c H e DNA`dG
e AGOCG FGdG JEG Gg qCG
q T h .CN q GC hO JhdG AH G J dG
.H RYEG g G e H 1 dW j dGh JhdG jL b
J dG dGh q dG ie d Vj FXd e AGOCG e HS cP e qEG
eh ,G FS IQe G JhdGh GdH e J dGh G G H
dG qCG
q T h .G d LP e iS kHS QcG G JG f
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q Q dG ,VQCGh GdG
q
q Q dG g G dG Gd QG dG Vh
edG I`e
148
j hQg
GDP
a Z {SGQz fCG
Sos SH3
Grb2
dG zSGQz fCG
Sos SH3
Grb2
dSQ
AG GC j edG JG j GC H
G JhdG H d NGdG
H JG Y hD G Grb2
j IG g H ,G JhdG
Yj NGB JhH H Grb2`dG
SOS
edG I`e
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cG
(CG) dG
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dG Gg C fCG dG qGE T Hh ,f AJ e C j CG Y f Y j
.dG Q dG g a qGh
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YS e fQH VGe
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151
edG I`e
152
j hQg
ddG Ib
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PDZ fCG Me
cG
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INAD
153
edG I`e
154
j hQg
dG fOh G G NGO JG
dG acG e dG G JG T
GN dG Nh jdG dG e INCG GdG
UGh aG QeCG e jdG Y dG IQL
dP Y eh.eLCG YCG JG jH
Z G JG dG acG
f e dG Hf FGL fc VG GdG
155
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edG I`e
fL EG G JG W HCG q S
Gg Y K dG fCGh ,iNCG HCG
n nNn sdG n go h}:J
b
n
IN NBG g e PEG.HCG d f g dG
nr njhn unrdHp VQnC rdGh pG s dG
Hc jQJ) 2001 S jG dG dEG UJ
o ndhn t n rdG o odr bn o on an co o o j
dG Y dG G aG g e ?(QdG
q g
?acG M j CG jG
opd Yn Qp t dG on roj nr nj oro rdG
e Ic LQO Y SCG g Y HLEG qEG
o p n rdG n go hn pIOn s dGh pr nrdG
IQH dh Yf HLCG g qGE h ,gCG
.73 :fCG | o p
n rdG
WG N e jG d gG q dG FL
dGR eh ,H a hCG a JG f Y
GdG e jdG Ie G Gg HCG
SDe qJ bh .GQhdG e IjY GQe EG fGe J SDe b eh
Alliance for cellular signaling G JG OG SG 2000 S HCd
dG Hf IFL Y FG c jdCG OG Gg SCGjhAFCS SDe QNH hCG
Gg jh .G JG KHCG f IFG g Y RM bh 1994 S
.AdG e G fL EG eL hY OG
aH dG b dG
q EG q G MG GPEGz :OdG
q Gg jdCG QahdG jh
c H dG b q dG e jG EG dG LMG GPEGh ,dH dH e gh
J G jG H e RJ FdG FSq dG e G gh .e cCG
dG e HGd q e VJ G jGh .NBG dG KDJ c eLCG
... J ch J j a ,eRdG dG dG FSdG d FdG
.48 fCG g H dGh JG ebEG c g idG Gh
c kqe G Gg HCG AGLEH AFCS QcG OG b GdH dG
q Gd
kae aSG KHCG AGLEG OqJG CGS :( dDG J Sb H e) j
156
j hQg
157
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f V FXh SQ GYh L Y FGMG Mf
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QGO e QOU j hQg dD {G Iez c LGe Lj
dG dGz
q ch 2000 S R fSG d GQhh
fc fSG ,d GQhh QGO e QOU f dDd {qd
IQGOEG jdG dhQc e AY q jh .(2001 dG
.51Qjf e Ic j dGh IQGOEH G dGh
LGJ G dG OY J dG Jhd J Yh
B JhH jL Qe e cCG Y N qa ,WS FM
ke f fYO bdG Gg eV ie QJ LCG eh ,52GfCG
SCG c dGh IMGh N JhdG q H b d :JBG G
Gk Qfh kd fdG MGh JhH YHh QG Y gOY Hj dG
M M d eCG ,q dG f c S 32 EG M f CG hO
kac c dG c dP HT eh dGh cCG FdG bdG
Gg Y f GQe 7 GM dg c d GPeh ,dcE
,N jJ 100 Y L j e MGh ch cdG
,cdG Gg Y IOLG JhdG OY J FY
Ie GC J a ,e O dM JhdG g c EG aVEH
G OGG EG J c e fG eCG VG EG T c
Mh iNCG Ie e JhdG H J dGh G NGO
L j dG G GG Sh ,53 LG
cJz H YJ IMGh jL eCG VG
NH FXh AGOCG JhdG g Jh ,{JhdG
GN c Gk QhO j kfCG j a ,YGfCG
jdG f
G NGO
cG Gm
G eRHhfG dG
hRjdG m
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eRHhfCG dG
jQfcjG
IGdG AZ
Sj
c L
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jdG
IGdG AZ n
IGdG
G AH
NBG dGh IG fedG EG j NBG Hh kjJ jG FdG YdG
J Y a G j IYG EG aVEG ,fCG EG cCG jEG j
cJ Y UdG e jdh).iNCG JM FXhh q dG dG
q J e H
GQhh QGO e QOU j hQg dDd {JhdG Iez c LGe Lj JhdG
.( 2001 S f ,fSG d
G NGO UG G cG g d kb gY bdG j dG dCGh
JhdG g qC G kjM cG JhdG H bGd G OdG f
UN R EG f j Hh ,a S dG bGG EG J CG j kjM YG
QN LGNEG j LQG Sd kjM Ye JhH gh .dEG LG M
J QG e eOb iNCG JhH g AKCG J h ,G AdG b e G
cM e Gk AL d kjCG h AdG ISh HbQ V G EG Nq d jW
.jG JhdG
Mq dG Mh ,IOG dH iJ dG G NGO V cM g RjEHh
160
161
bdG (Vesicle) jG
hRjdGm
hRhdGl
kjM e JhH m
dG
eRHhfCG
hN
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Y G
G
JhdG jJm
I RG jG
G AZ
?CN CG JQG hO Gh G cG g e J
kffEG g CG Vf fYO IG g dh G NGO bG f CG hdh
d CH jG OdG Gg Yfh ,dG jM JhH OLh e kH kjM Gk Ode
gh FGM bH Abh dGh cCG OjEG c j kjjh kjT Y dO
jG Y j IOdG jM dG qGC Th ,f Qe GP je j
OjEG Y j dH Ic HU bS dh ka kT dM e Sh
Gd jG g AdG Y dd ,dH G jG g HG ceCG
e fEGh ,Y j dG G dH j dHh YQGTh bRCG j c jW
dG Y JhdG eq GC ,jW Ih Gk c jh Gk L C j CG Y HdG G dG
.q eCG dH Ggh G NGO OLh e e e g e c j a
ec aOJ dG fGG c IR aGgCG f JhdG c dGh
q
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162
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YdG d ke Gk eCG j
CG YEd Gh ,jjdG eG
j e OLh KCG dG HCG
hGh ,54G jdG edG f
OG SGH cJ j JhdG CG
T V eCG VG e G GdG j GC j dGE SG GdG GE e dSQ J d
jL kUN Gk AL CGh ,e Sg a G eC G dc ,dG Y He jdG edGh
J dG jjdG RedG e S kjM j JhH
KK EG IY H e jdHh JhdG
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j SSCG Gg Yh ,NGO hCG JhdG jL W j jdG edG Ggh
g CG EGh c H UG eG j CG G kjM cG JhdG
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RGaEG
c L
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GQTEG S
JhdGi
GQTEG S
JhdG
IGdG
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fG ISdG
SGH JhdG LJ c Vj dG q dG Gg
G H kjGC dG Vjh ,jdG edG f
(a JdG jG Lj L SHhQdG ) ,G
kq UN kjq jH kGeQ j AL Y kjM e JhH c j
VG e S e AG Gg qdC jh ,JhdG dH
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163
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U c hG jM
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hRjdG
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Ga
c L
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Ga
jQfcG
(bdG dJ ce)
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SRP
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hRjdG e
JhH
SRPe
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Ga
j hQg
jG g Y j dG g h
dG AZ N e QhG
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j AdG Gg Y
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gh NBG kbQN kJ Of gh .e
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j JhdG fEG Y hDG hRjda
Ggh ,e S T Y LfEH
UG Jb e JhdG Qhe EG ODj
kM j fE G ej dG jdG eqdG f qGE
EG IdG J JhdG Qhe Hh ,dH
.kjM G JhdG LJ d kde
Y j FYh ,NBG Qhe hM M
Y Hh ,e fCG IY JhdG jL e a jh JhdG jdG edG
AfG J dG g .OHCG KdG T NCd JhdG jL J ITe fG
.ag EG dUh H dSdG Y hG dG gCG
jdG edG Y fCG J c J dG g iNCG IGh
g eb GPEGh ,JhdG e j dG eCG VG BG hCG e e JhdG
Gk KCJh kT JhdG J j Ga iNCG eCG VM H (kVa ) fCG
dh ,dG g GN e IN c Yh e S d j Ggh .gCGh
,GMCG e M CH jG g EG Oj dG hCG G dG Gg CG G
h JhdG edGh SRP L CG CG ,je UJ H J dG CG bGdGh
jLh G GY AZh fCGh JhdG Qhe Ibh Gh hRjdG
JH Y hODj jG ADg L ,G jG dG gQhO ODJ iNCG
,G dEG Ie Md QYG Jhd jdG edGh ,bQN fGh
JhdG jdG edG eq CG kjJ S 40 e jdG edG f j fEGh
165
edG I`e
d UN eQ OLh AdG j
.jL RL H JhH
166
j hQg
167
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H f QJ
qdG Jh gGC d
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kM dG g a
jh , qMS Te GE
TG S SRP`dG
LJ f MdG
Lh f JhdG
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168
j hQg
G IGf UGGh q dG
Y fC KGQdG JU d f J fCG G IGf Y kY hG
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aGYH qGE d ''ke kL'' fc Rhj h ,Y dO CG G j jhQGdG AYOG Gg qEG
aGYG de IQH hJ '' jdG Ye'' SH H Y iMG dG EG M ,kT g
dH d ,SG OhOdG d CG jdG J dG SCG e jdG OLH f jhQGO
.jdG H ja GK
jd Ib e dG QdG d SCG d SG OhOdG QH dG j CG j ch
210
j hQg
Gk HGC bG Z IG : IG UGC
.S Qe3^8 b IMh N e Cf cCH G FdGh IG qCG Qq dG jf Yq J
dG M e G G FdG GfCG e jG EG J CG IMGh M c dh
?dP J Ge jCG LJ GPa ,ka M b dG Gg c GPEG h ,cdGh
AYOG Y bdG j UdG g VG bh ,Y HLEG jdG J DhdG Gg qEG
X G g CG jdG YJ ?OLdG EG X c iJ .''CG G'' J Gh hCG
Z hCG LQN KCJ CG dg j CG hO dG hX X h gMh aOG f OLdG EG
H d KM M Z kGOGe qGC jdG YJ :NBG ,kWb kaQ G Ia aJ fEG CG ;W
. ahG dG YGdG ac e ke aj AYOG Ggh ,M N QX EG dH OCG aOG
''IG e C J IG''
dG gG W qj dGh ,QcG Hc IG UCG Y kGHCG jhQGO dQJ j
GfBG dG ch .kGL H OGe e AMCG J Va RhJ dGh ,Y IFS fc dG
sOGe qCG gOeh ,SdG hdG e JS VJ fc dG ''FdG ddG'' jf KCJ Gj e
.M OGe fCG h aOH b M Z
GG KJ e OYG Gg J EG SdG H J fc edG G H gh
H fc jdG GAYqOG g KEh .G eGU GdG KJh qdG a
M QdH GdG GC J kb QfG Yh , m H Tb b Y G e M Vh e QdG
. IdG J SdG OYG
211
edG I`e
jdG dG dG hG
IG UCG Ve hJ e hCG jQHhCG QdCG AMCG Y ShdG UNG c d
J G Z OGG CG KE jdG dG qKK IjY kKHCG iLCGh ,jdG dG
kFb IQG j CG G VGh jQdG dH AH KHCG dh ,aOG jW Y M OGe OjEG
83
.'' eH QdG jf J AGOS f tnoj G UCG qEG'' :
KHCG GhLCGh jQHhCG S dG f jdG GhSGh ,QdG IYO e AdG bH SCj h
M 1953 S e fS jeCG FdG b e LCG H TCGh .IG UCG EG Ud
GRdG g Vhh ,dG VG G dG e GRZ GP OGe OLh VaG
cJ NJ dG eCG VMG H Y j CG SGh ,bdH gLh MGh e
. JhdG
OGG C ;a K e YS dh ,eCG EG e IN GdG
q J HdG g s Yo h
K dG Ggh ,dG VG IOLe fc dG OGG M J HdG eG
84
.MdG GdG cCdH
J HdG AGLEG eSG dG OGG CH j CG f e VG jW U Ia Hh
85
.edG dS G dG LJ fc dG OGG M
dhJ G gh ,jdG dG GW jhQGdG gGLCG dG QdG c dH AHh
212
j hQg
213
edG I`e
QdG jd dG dB G
AYOG Ga '' QdG dBG '' M QhJ fc jhQGO jf f kS fc dG fdG dG
AYOG Mh .G jdG Hb Y FGMG dh kY U d dG fO e CG j
Gg qGE M ,AYOG Gd FSG gCG YCGh ''dG fG'' f M QdG qEa jhQGO
. '' dG fG jW Y GfCG UCG'' SCG dG dG SG e j b e gG
hdG eAeh Ib J dG G FdG AH GC e EG j dG fG e qEG
hdG SCG jCG Ea SG fGG b e jG e b Ouog d :G S a ,dG
dBG g dh .hdG jS AjbCG jjCG e kdCe dG j Ggh ,IG b Y AdG j
fG'' J dG
q Gd .ke N EG d Cc ,NBG EG T e jjCG QJ CG J
'' GfCG UCG '' Hc V H cPh dP j c f jhQGO M h ,Qd Sc ''dG
88
.''G VdH j dG fG Ea HjEG GJ J W'' :j
Qe KC J
Y jhQGO LCGh ? HjEG GdG g S fc c :f j dG GDdGh
TY fa AMCG Y Qe h ,Qe e Y LQ e S e QaCG EG kGOSG GDdG Gg
,MdG LCG EG KQJ e GJ J AMCG CG Yj c GH jhQGO b eh
aGQq dG qE a FYOG Mh ,IjL GfCG QX EG Oq GC L H kL GdG g cGJ ch
jhQGO YCGh .jW MCG Y ddG QTCG GQhCG Y d Jh f dG e Cf
Y iJ fc dG HdG e Ob UCG G CG YqOG a ''GfCG UCG'' Hc He eCG
cG dG KGQdG fGb CG EG 89 NBGh G H AG EG hdG EG Ie fch FG FdG
fH FdG IQSCG jf EG iqOGC jdG dG G Y Y GC W dG QdGh e
e KCJ hCG IFa GP Z dBG ''dG fG dBG '' X Ggh ,NBG EG L e G dG
.jG dG f Lh
214
j hQg
SdG d KGC : GG S
,QdG jf YqJ dG gjQdG e CG hM Y Y dO aCG GqG S tno
FdG e e a ,NBG H e H Cf GfCG qG FdG qCG YqJ jdG a
,AMCG e G GfCG X SdG Hh ,edG Qh NBG f EG j CG G e G
215
edG I`e
jhQGO eGB N
CG Y j dh ,BG Mh Y SdG dG e e kGL Ic Jh jM jLCG
c e Y jG f Y G dG GG KCG bh ,'' dfG TCG '' d KCG
. IQU cCG Yh ICa OLdG EG X b YGfCG AMCG L CG e ;jhQGdG bj
Y jdG UNG jGh jjO gh qjhQGdG IZ MCG G H YG bh
ie Y fcCG AGS ,ec M Fc Y dM g G e qEG'' :kFb GG
KCG
q GC Y QdG hO kehO LGh dG gh ,G Gd J Y UCG CG GfCG
OLh CG hO ICa ac AMCG QX d J GG EG CG . 92 ''kjQJ IQG bG d
G FdG g c Y J Ggh ,jhQGO dEG gP e Y kW Ggh ,kjf dfG TCd
gh ,kb j CG g e L d j CG hO ICa M Fc Qd MdG dG C ;b
:Ja SZhO e Qe AMCG Y b b G
Lh qeEG AMCa ,AMCG OLh d dG fO GFS GJ hCG ee QdGh G qEG''
hCG GfCG Y gQJ f X fCG CG ,dc J hCG IQU cCG Y dG Lh Y ICa
M Ib e Ha jdGh dG ec IQHh ICa X b fc EGh ,OLdG S OGLCG
216
j hQg
93
fE G Q q J IQSGC
OdG Gg h ,fEG UCG TH g QdG jf V Td MhG YVG gCG e qEG
,dG VG TY OdH T M Fc e kGQe Cf G fEG CH jhQGdG YJ
IdG N dfG TCG H OLh jdG YJh ,S je 5-4 b CGH QdG Iah
: gh fEG QJ Y V FQ Y HQCG g G AYOG Gg Mh ,IQcG
Australopithecus SHdGShCG-1
Homo habilis Hg eg-2
Homo erectus SjQEG eg-3
Homo sapiens HS eg-4
dh ,G Ob hCG '' SHdGShCG '' SG G fEd YCG G Y QdG IYO j
q c gGLCG dG HCG KCG bh ,G OhdG GfCG e V`e f iS d bG g
AY TCG e gch eNGR dS OQdG jdGh OQchCG dQJ QahdG jeCG e
ke d bY h OhdG e Ve f iS d G FdG Gg qGC G Ob Y jdG
94
.fEH
MGe ac h ,fEG hCG ''eg'' SG jhQGdG b e Y j G Ob J dG MGh
UG GG VH jhQGdG jh ,G Ob e kGQJ cCG G FdG UCG ''eg''
,G QdG hG Gg e OLh Y kGcCJh jf U Y dc VG GfCG H
dG g h .G GfCG g H QJ HGQ CG OLh BG EG j fC ;N :fh
IG dG qEG'' :kFb je fQBG gh jdG dG QdG jf IYO MCG H YG dG
95
.''IOe H G e HS eg EG
eg (SHdGShCG) G Ob e J U KEG jhGQdG hj S gh
dG acG dh ,j qd kGL j ebCG EG CG HS eg ` SjQEG eg ` Hg
ceCG GhLh b SjQEG eg h Hg eg h G Ob CG KCG GG AY gLh
217
edG I`e
218
j hQg
jOe IY
bJ ieh ,dG gGdGh dOCG e bJ ieh ,QdH UG jdG VSG d
dBG ad QdG KCdG GfG c kjCG VSGh ,dG YGdG e IG UCH G ga
Y Id dfCG TCG OLh J G QKBG jCG OLh GfGh ,jdG g dEG YJ dG QdG
dG YGb e be J dG jdH dG Y dG IQhV EG Uf dG Gd ,jQdG
ce VQCG CG H YOG dGh jQdG Y iNCG jf fG c J CG Hh ,dGh
H gh ,dG GMCG LGh jdG g AH Y kY kGQGUEG g dh .dG
. AdGh dG Y g fCH jd f CG jh eJ iOj
G gh ,dG d Sc eGSGh jdG d G H J j dGh
N jhQGdG Jh YCG kJG OG dH e g H ,jOG SQG e Hf fCH gJ j
. dG OG ga jhd d a Pe
,G Y MdG TCG fd OQjQ j c ,HdG
q H G g J kfMCGh
:Oe Y LQ f jh QdG jf Y SdG aGG e g h ,OQaQg eL j dGh
jOe GJ Lf j dG g EG Ggh ,kS H sn eo ATCH eDfh ,jOH eDf f''
HCG d OhdG YO S g jOH G fEGh ,FOeh dG YGb dh jfdG gGd
a kbWEG U jOG dh ,Y LJ dG ac gGd jOe GJ OjE jQG
100
.''GMCG LGh EG J CG qdEG Gd f CG kGHCG
ka kHGJ HGe fc O jhQGdG H J dG dG ie J dG g EG
Z OGG CH eDj dG Gdh ,IOG a AT CG jdG g UCG IZ jh ,jOG jdH
QdGh aGQdGh ASCGh Qdc G GfCG e jG EG CG ,G OGG OLh S g G
Y GC W dG NGdG d kLf EG d fEG Mh Gh QgdGh QTCGh GGh
.YGdGh YdGh G c IOG
Y aGj GdGRe qjhQGdG qCG EG ,dGh dG YGb e ke VQj OYG Gg CG bGdGh
.'' GMCG LGh EG J CG dEG Gd f CG kGHCG '' aGgC eN FGQBG
WdG G ij CG d H jOe Z f Lh e AMCG UCG b EG j fEG q c h
dN b e npoN :CG ;d M Yh ge Ib KCH npLho b G FdG ac qEG ,dc
. a c :d bh dG e AT c N dG jdG dG dG g dG Ggh ,d
219
edG I`e
220
j hQg
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
221
edG I`e
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77 R.H. Epstein, "Puff the Magic Gas", Physicians Weekly, say:XIII, No:31, 19 Austos 1996.
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83 Alexander I. Oparin, Origin of Life, (1936) New York,
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222