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  • Regeneration and Repair: USMLE Step 1 Web Prep - Wound Healing and Repair

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    1) Wound healing and regeneration involve the proliferation and replication of labile cells like epithelial cells, while stable cells like hepatocytes have a low level of replication. Permanent cells like neurons cannot regenerate. 2) Tissue repair replaces damaged areas through fibrosis mediated by growth factors and cytokines, forming granulation tissue with fibroblasts and capillaries that contracts and forms scars. 3) There are two main types of wound healing: primary intention where surgical wounds are approximated, and secondary intention where large defects are filled in by granulation tissue and contraction leads to scarring.

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    patho 4

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    1) Wound healing and regeneration involve the proliferation and replication of labile cells like epithelial cells, while stable cells like hepatocytes have a low level of replication. Permanent cells like neurons cannot regenerate. 2) Tissue repair replaces damaged areas through fibrosis mediated by growth factors and cytokines, forming granulation tissue with fibroblasts and capillaries that contracts and forms scars. 3) There are two main types of wound healing: primary intention where surgical wounds are approximated, and secondary intention where large defects are filled in by granulation tissue and contraction leads to scarring.

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    4 views2 pages

    Regeneration and Repair: USMLE Step 1 Web Prep - Wound Healing and Repair

    Uploaded by

    frabzi
    1) Wound healing and regeneration involve the proliferation and replication of labile cells like epithelial cells, while stable cells like hepatocytes have a low level of replication. Permanent cells like neurons cannot regenerate. 2) Tissue repair replaces damaged areas through fibrosis mediated by growth factors and cytokines, forming granulation tissue with fibroblasts and capillaries that contracts and forms scars. 3) There are two main types of wound healing: primary intention where surgical wounds are approximated, and secondary intention where large defects are filled in by granulation tissue and contraction leads to scarring.

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    of 2

    USMLE Step 1 Web Prep Wound Healing and Repair

    137760 >>> 0:00:00

    SLIDE 1 of 5

    REGENERATION AND REPAIR


    Wound healing Regeneration Repair Regeneration Labile cells o Proliferate o Epithelial cells Stable cells o Lo le!el replication o "apacit# to di!ide o $epatoc#te Per%anent cells o "annot regenerate o &eurons ' cardiac %uscle
    13776( >>> 0:0):00

    SLIDE 2 of 5

    REGENERATION AND REPAIR CONT


    *issue repair Replacing da%aged area b# fibrosis +ediated b# gro th factors ' c#to,ines -ranulation tissue o .ibroblasts o "apillaries "ontract b# %#ofibroblasts Scar for%ation
    137770 >>> 0:03:)/

    SLIDE 3 of 5

    TYPES OF WOUND HEALING


    Pri%ar# 0ntention Surgical ound1 appro2i%ated edges Secondar# 0ntention Large defect1 granulation tissue "ontraction Scarring
    13777( >>> 0:03:)(

    SLIDE 4 of 5

    ABERRATIONS IN WOUND HEALING


    4ela#ed ound healing

    Prolonged b# infection

    $#pertrophic scar *oo %uch granulation tissue production 5eloid


    -ranulation tissue e2tend be#ond -enetic predisposition 6frican 6%ericans Earlobes 7iops#1 collagen t#pe 000

    ound

    137780 >>> 0:06:(6

    SLIDE 5 of 5

    CONNECTIVE TISSUE COMPONENTS


    "ollagen *#pe 0 +ost co%%on Strongest S,in9 bone9 tendons ' %ost organs *#pe 00 o "artilage ' e#e *#pe 000 o -ranulation tissue o E%br#ogenesis *#pe 0: o 7ase%ent %e%branes o -oodpasture;s1 antibodies against t#pe 0: collagen
    o o o

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