Aspirin (irreversible) Ibuprofen, etc (reversible) Celecoxib

COX-1 No effect

COX-2 -

PGI2 -

TXA2 No effect

Hyperkalemia EKG increased PR, tall peaked T wave, wide QRS Medicines spironolactone, triamterene, amiloride, ACEIs Tx CaCl (stabilizes membrane), NaHCO3, insulin/glucose infusion (shifts K into cells)

Hypokalemia EKG U waves, flattened T waves Medicines furosemide, thiazides

Normal Pressure Hydrocephalus incontinence, gait difficulty, mental decline

AutoAbs AMA primary biliary cirrhosis Anti-centromere CREST syndrome Anti-histone drug-induced lupus

Anti-dsDNA SLE ANA, anti-Smith SLE Anti-phospholipid Ab (anti-cardiolipin = lupus anticoagulant)