T BO MU - TO HUYT

TS. Trn Th Thanh Loan

MC TIU
- Tb mu - S to huyt

T BO MU - S TO HUYT
S to hng cu S to bch cu
Bch cu ht
Bch cu trung tnh Bch cu a acid Bch cu a base

Bch cu khng ht
Lympho bo Mono bo

S to tiu cu

Huyt tng: - 92% nc - 7% protein - 1% thnh phn khc

Tiu cu: 120-300x103/mm3 Bch cu: 5-10x103/mm3

Hng cu (43 - 45%): 4.2 6.2 triu/mm3 Hematocrit (Hctdung tch hng cu

S XUYN MCH CA HNG CU, BCH CU V TIU CU

Bch cu di chuyn ch ng Hng cu di chuyn b ng Tiu cu cho nhnh bo tng xuyn mch

HNG CU
phng i X3000(SEM mu): hnh cu lm 2 bn phng i X250: Trong mch mu. HC xp thnh chng

HNG CU LI LIM

Sickle cell erythrocyte

Gen t bin HbS nht mu ln Lu thng vi mch km X6500
X6500

DIN BIN TO HNG CU

BCH CU

BCH CU HT BC A NHN TRUNG TNH (BCTT)

1215 m , 2-5 thy Tiu thc bo, chim khong 60 -70% Bc ngoi vi BCTT vn ng mnh bng gi tc, chng d dng lch qua thnh mao mch n cc vim. Sau khi thc bo BCTT cht v tr thnh i tng thc bo ca i thc bo

Golgi trung tm nh. ER v ty th khng nhiu TEM, X27,000

BCH CU HT BC A NHN A ACID

phn ng d ng nhim trng giun sn (k sinh)

BCH CU HT BC A NHN A BASE

large specific basophilic granules (B) mitochondria (M) and Golgi complex (G)

TO BCH CU HT HNH THNH HT A AZUR (HT C BN)

TY TO HUYT

PHT TRIN CA HNG CU V BC HT TRONG TY XNG

mitotic figures (arrows) plasma cell (arrowhead)

CAC GIAI OAN (KHU VC) BACH CAU TRUNG TNH (1): KHU VC TAO TRONG TUY XNG (2): KHU VC TCH TR TRONG TUY XNG (3): KHU VC TUAN HOAN (4): KHU VC THANH MACH

X400. Giemsa M: megakaryocyte i bo S: sinusoid mao mch kiu xoang

X10, 000. TEM: transmission electron microscopy N: lobulated nucleus nhn chia thy G: cytoplasmic granules hat bo tng

BCH CU N NHN
Bch cu n nhn to mu ngoi vi, tin mono bo, t bo tin thn ty xng v cc i thc bo t chc. T bo thc bo n nhn chim khong 3-8% tng s bch cu mu ngoi vi T bo ny c tnh hot ng mnh, vn ng bng gi tc, lch qua c thnh mao mch vo cc t chc (m) ca c th

LYMPHO BO T
Lympho bo T chim khong 70% tng s lympho bo mu ngoi vi, v chim a s cc lympho bo cc m lympho. Chc nng chnh ca lympho bo T l gy c qua trung gian t bo
Mu: 65 - 75% lympho bo T/tng s cc lympho bo Thymus: 95% Hch lympho: 70 - 80% Lch: 20 - 30%

CC C QUAN TO HUYT
TS. Trn Th Thanh Loan

MC TIU
1. Phn bit c c quan to huyt trung ng, ngoi vi. 2. M t c cu trc m hc ca hch lch v hnh nhn

 C quan lympho nguyn pht: c quan lympho trung ng C quan lympho th pht: c quan lympho ngoi bin Min dch t bo (lympho T) Min dch th dch (Lympho B Khng th) Min dch bm sinh (i thc bo, BC trung tnh, Lympho T st th ) (Lymphocyte T killer) Min dch mc phi: c ghi nh, nhiu loi t bo v yu t

CQ TO HUYT TRUNG NG TY TO HUYT

CQ TO HUYT NGOI VI HCH BCH HUYT LCH

TUYN C

Tu to huyt => HC, BC Ht, tiu cu, Lympho bo B, tin thn Lympho bo T & Mono bo. - Cc c quan TH khc => Lympho bo

C QUAN TO HUYT TRUNG NG: TU TO HUYT - mt s xng dt & u xng di. - sm. - To t bo mu. - Cu to
- M li - Mao mch kiu xoang - Tb to huyt u dng

TY TO HUYT

C QUAN TRUNG NG: TUYN C (THYMUS)

Ngun gc trung b v ni b
Vng v m mu (tb tuyn c) Vng ty sng mu ( tiu th Hassal)

V tr cho lympho T pht trin C quan chia thy mm

Trung tht trc v sau xng c. y ta ln mng ngoi tim , ko di phn di c

 tr s sinh: - Vng v c chia thnh cc tiu thy phn cch bi vch lin kt - Mu xm nht, m m xung quanh C: cotex vng v M: medula vng ty S: fibrocollagenous septa vch

ngi trng thnh: - C s thoi ha sinh l - Tr thnh mu vng do cha nhiu t bo m

VNG V TUYN C

VNG V - VNG TY TUYN C TIU TH HASSAL

V
Tp trung lympho nh t tb lympho ln v i thc bo vng ngoi vi C hng ro mu tuyn c (tb ni m mao mch, mng y tb ni m, i thc bo)

Ty
Nguyn bo lympho v tb li t i thc bo Tiu th Hassal: tb li biu m b thoi ha (30 -150m)

C QUAN NGOI BIN HCH BCH HUYT

- Hnh ht u trn tun hon bch huyt. - To Lympho bo, bo v & d tr Bch huyt - Thnh phn chng - V x. - Vch x. - Dy x - Nhu m: - Vng v - Vng cn v. - Vng ty

S CU TRC HCH LYMPHO

Vng v: lympho B Vng cn v: lympho T Vng ty: sinh sn v bit ha lympho B

NG BCH HUYT
Bch huyt qun n Xoang di v Xoang quanh nang Xoang ty

TUN HON MU
M vo rn hch B x Nang bch huyt Ra khi bng TM r n

Bch huyt qun ra trn r n .

CU TRC VI TH HCH LYMPHO V:

Trung tm sinh sn trung tm phn ng (nguyn bo B kch thc kh ln) Ngoi vi ti mu (lympho B nh)

Cn v
Cu to t lympho T -> vng ph thuc tuyn c Tiu tnh mch hu mao mch -> tb lympho B v T t mu vo hch

Ty
Xoang Dy ty (tb li, lympho B, i thc bo, tng bo)

V X, XOANG DI V V VNG V NGOI CA HCH

VNG TY CA HCH

TIU TM C TB NI M CAO HCH

Tiu tnh mch hu mao mch c lt bi tb ni m cao ging biu m vung n -> tb lympho B v T t mu vo hch

CC BIN I BNH L HCH

C QUAN TO HUYT NGOI VI LCH

C quan lympho ln nht Thnh phn chng
V x Vch x (b x) Dy x (vng ty)

Nhu m
Ty trng (vng v, vng cn v): tiu th lch Malpighi,(lympho B), bao lympho vng quanh ng mch (lympho T) Ty (vng ty): Dy Billroth, xoanh tnh mch

CU TRC VI TH LCH

TUN HON LCH

M vo lch rn Chia nhnh vo b Vo nhu m lch M bt lng + Xoang TM + Dy Billroth

TUN HON CA LCH

TUN HON KN
Mu t M bt lng Xoang TM TM ty TM b TM lch.

TUN HON H
Mu t M bt lng Dy Billroth xoang TM Tr v TM

M LYMPHO NIM MC (mucosa-associated lymphoid tissue - MALT)

Hch hnh nhn c 3 v tr: di li, thnh sau ming v trn ca vm hng

MNG PEYER RUT NON

Mng Peyer c cha khong 30 n 40 hch dng lympho nm thnh ngoi ca rut

HOT NG MIN DCH NIM MC RUT NON

IgG V tr ch y u T l Mu

IgA Nim nhy cc dch tit

IgM Lympho B Mu

IgE

IgD

Bch cu a Lympho B base Tb mast < 1% < 1%

70% n 75%

10% 15% - 20% cc khng th trong huyt thanh Ngng t, trung ha vi khun, virus Ngng t, con ng c i n c a b th

Vai tr

Trung ha cc c t, vi khun, virus

D ng, trung ha cc k sinh trng

Hot ha cc t bo lympho B

Tm tt tnh cht ca cc lp (isotype) immunoglobulin khc nhau

CHC THI TT nnld2001@gmail.com