Najma Annuria Fithri

Introduction

TK TK Melati, Sungailiat Bangka SD Koonawara Primary School, Perth WA SMP Al-Kautsar, Bandar Lampung SMA Al-Kautsar, Bandar Lampung S1 Farmasi UGM, Yogyakarta Apt Farmasi UGM, Yogyakarta S2 Ilmu Farmasi Sains dan Teknologi UGM, Yogyakarta

CP: empith@gmail.com

Sistem Penilaian
Nilai mutlak Ujian akhir (50%) Tugas (20%) Kuis (20%) Keaktifan di kelas (10%)

Problems in Tablet Compressing

1. Capping and Lamination
Capping:- Partial or complete separation of top or bottom crowns of tablet main body. Lamination:- Separation of a tablet into two or more distinct layers.
Reasons: less binder, powder too dry, compression force too high, compression process too fast

2. Picking and Sticking

Picking:Adherence of the tablet material from the surface of a tablet by a punch Sticking:Adherence of tablet material to the die walls resulting in chipping of tablet edges producing rough edges and causing the lower punches uneasy to move resulting in damage of cam tracks and punch faces

Reasons: less binder, less antiadherent, powder too wet/sticky

3. Weight variation too high

Reasons: powder has poor flowing ability, compression speed too fast, granules powder too big/too diverse

Compactibility & Compressibility

Compactibility: is the ability of the powdered material to be compressed into a tablet of specific tensile strength Compressibility: its ability to decrease in volume under pressure Compact: static Compress: dinamic

Compactibility
Uses the parameter F (Force): Shows the depth of upper punch needed to compress a tablet to the strength of 0 kg F>400, poor compactibility Need to be combined with a filler (excipient) with F value less than 400

Compressibility

Quiz
A Sebutkan macam deformasi dan jelaskan Alat untuk mengukur stress saat pengempaan B Sebutkan amcam permasalahan yang timbul saat pencetakan dan pengatasannya Macam alat pencetakan tablet

Quiz
C Macam interaksi yang terjadi agar terbentuknya tablet dari serbuk (minimal 3), jelaskan Sebutkan 3 bagian utama dari mesin tablet

D Gambarkan dan jelaskan kurva profil pengempaan baik untuk saat terjadinya pengempaan dan saat penarikan punch atas Perbedaan kompaktibilitas dan kompresibilitas