Still have many subject/verb disagreements in the PDF You need to set up the rationale better.

Why do platelets clot. What effect would nanotopography have? How would it solve the problems mentioned above which would, in turn, prevent clotting? As for the fabrication, do you want homogeneity? On what scale? As for the platelet study, you cannot learn anything from incubating the platelets with your substrate. Think of how they move in the body over a stent. You need to mimic that.

I think in terms of the project, you should start off with animal blood (like rat or rabbit). It would be easier to get an IRB on that instead of for human subjects. The paper you found looks like something you can work from. I wouldn't worry to much about how the set up is well thought out. That's great for you - less work you have to put in to creating a flow system. Your innovation is study how platelets are affected by surface nanotopography. You may also want to consider adding a protein layer on the surface of your patterns. Mary made a lot of comments since she has more experience with platelets, so I would look at those.