QUESTIONS: 1. What is the primary reason why the Epstein-Barr virus vaccine is still not developed?

a) Vaccines that attempt to rid the memory B cell of the EBV also cause harm to cells in general b) The virus expresses very different proteins during its lytic and latent phases c) The vaccine only inhibits the DNA amylase. Answer: (b) The virus expresses very different proteins during its lytic and latent phases During replication, only EBV DNA synthesis dependent on the viral polymerase (the linear form of the genome) is susceptible to inhibition. The latent circular form of the genome, which replicates in concert with the cell cycle using the cellular DNA polymerase, is not selectively inhibited. To address this, vaccine candidates have been designed to include proteins from both phases. 2. It is a vaccine against Rotavirus that contains five reassortant rotaviruses developed from human and bovine parent rotavirus strains. a) RotaTeq b) Rotarix c) Rotashield Answer: (a) RotaTeq RotaTeq contains five reassortant rotaviruses developed from human and bovine parent rotavirus strains. 3. Antiviral drugs can have both therapeutic and prophylactic effects. But to prevent disease they must be administered continuously at times of high influenza activity. *From the two statements, determine if: a) Both statements are false. b) Only 1 statement is correct. c) Two statements are correct. Answer: (c) Two statements are correct. 4. Several antiretroviral drugs treat HIV infection but do not cure people of it. But more recently, a treatment was developed to cure people of the infection. *From the two statements, determine if: a) Both statements are false. b) Only 1 statement is correct. c) Two statements are correct. Answer: (b) Only 1 statement is correct. 5. The final injection of Hepatitis B vaccine is for a) Long-term protection against the virus b) Complete protection c) Short-term immunity against the virus Answer: (a) Long-term protection against the virus