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PATHOPHYSIOLOGY MODIFIABLE FACTORS - Diet Low in protein and folic acid - Nutritional deficiency NON MODIFIABLE FACTORS - Age

over 40y.o - High parity - Abnormalities in the uterus

COITUS

HAPLOID OVA 69xxx or 69xxy chromosomes (COMPLETE/INCOMPLETE)

HAPLOID SPERM 90% 46xx and 10%46xy chromosomes (COMPLETE) 69xxy or 92xxxy chromosomes (INCOMPLETE)

2 sperm fertilize 1 ovum

Duplication of Haploid chromosomes

Abnormal Fertilization

Hyperplasia

Swelling of Chorionic Villi

Vaginal Bleeding

Excessive Uterine Enlargement

Thromboplastic tissue formation

Tumorous growth in placenta

Formation of moles

Complete/Incomplete Mole

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