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NSAID flashcards | Quizlet

NSAID Created by meddyping

58 terms

Prostaglandin

NSAID

enzyme

Phospholipase A2

Arachidonic acid

prostaglandin

membrane

COX

Arachidonic acid

prostaglandins

PGH2

Intermediate form
prostaglandin

tissue

PGI2

prostacyclin

HDL

hypernatremia, hyperkalemia

NSAID

peptic ulcer

NSAID

prolong labor

NSAID

TXA2

PGs

PGI2

PGs

vasodilation

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prostaglandin E2

IL-1 beta IL-6

PGs

Hypothalamus

blood brain barrier

PGs

PPI

60

NSAID

peptic ulcer

misoprostol

prostaglandin analog

peptic ulcer

NSAID

mast cell

Skin reaction

ADR NSAID

cell

hypernatremia

ADR NSAID

hypertension

COX1

NSAID

Lipoxygenase

asthma

NSAID

arachidonic acid

leukotrienes
enzyme

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anticoagulant

NSAID

Li+

bipolar mania

NSAID

Na+

Na+

NSAID

bipolar mania

aspirin

Irreversible COX inhibitor

COX-1

NSAID

specific COX-2 inhibitor

NSAID

GI side
effect

peptic ulcer

coxib

specific COX-2 inhibitor

NSAID

underlying disease

bleeding

Salicylism

ADR
CNS aspirin

Reye's syndrome

NSAID

aspirin

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Diflunisal

salicylic acid

aspirin,
BBB
,
GI side effect

Diflunisal

skin reaction

Side effect

Ibuprofen

Piroxicam

NSAID

half-life

GI disturbance

Piroxicam

NSAIDsinduced peptic ulcer

NSAID

Diclofenac potassium

Diclofenac

Diclofenac sodium

Diclofenac

Parecoxib

Specific COX-2 inhibitor

anti-inflammatory

Paracetamol
PGs CNS

platelet

paracetamol

Paracetamol

drug of choice

CYP2E1

hepatic necrosis

paracetamol
metabolized

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Glutathione

toxic metabolite

paracetamol

xanthine oxidase

Allopurinal

chronic gout

Colchicine

migration of WBC
tubulin
microtubule

Diarrhea

GI side effect gout

Agranulocytosis

gout

Allopurinal

Mercaptopurine

azathioprine

chemotherapy

uric acid

chemo 2

Uricosuric agents

allopurinal

chronic
gout

GI irritation

Probenecid, sulfinpyrazone,
benzbromarone
ADR

allergic dermatitis

probenecid

uricosuric agents

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immunosuppression

Rheumatic
disorder

dermatitis

Gold salts

gold sodium
rheumatic
thiomalate, auronofin
ADR

Agranulocytosis, aplastic anemia

Gold salts

rheumatic

retina

Chloroquine &
hydroxychloroquine
ADR

Sulfalazine

rheumatoid arthritis,
ulcerative colitis

ADR

1. skin
2. reversible male infertility
3. fatal blood dyscrasias

Penicillamine

rheumatic disease

Methotrexate

immunosuppressant

rheumatoid arthritis

DHODH

Leflunomide

T-cell

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Adalimunab

fully human IgG1 anti-TNF

monoclonal antibody

Infliximab

chimeric monoclonal
antibody
TNF-alpha

Etanercept

soluble TNF receptor protein

TNF-alpha

surface
receptor

monotherapy,
combined therapy

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