Outline 10 and11 1. Visceral smooth muscle a. Deglutition OPE b. Swallowing Reflex i. Vagal excitatory ii. Vagal inhibitory c.

. Peristalasis 2. Esophageal motility a. UES (vagus,ACh), body, LES (myenteric,NO) b. Fig4 and 5 3. Slow waves and motility a. ICC, Ach, NoE 4. Gastric motility a. Gastric emptying: PERMS i. Sieving/retropulsion b. Gastric control i. Para= + ii. Gastric distension = + iii. Sym, secretin (acidic), CCK (LCFFA) = 1. Feedback inhibition = 2. F-HAD 5. Small Intestinal Motility a. Fed i. MEN ii. Enteric neuron control frequency of phasic contraction iii. Segmentation and peristalsis iv. GAINS v. DOESN'T 1. Imodium = opiod receptor agonist treats diarrhea b. Fasting MMC i. Housekeeper ii. Only in small intestine iii. 3 phase = motilin iv. erythromycin = motliin receptor agonist diarrhea for gastropersis 6. Colonic Motility a. Parasym vagus nerve CAT RPP b. Pelvic nerve DSR RS c. Sympatheic nerve colon RM d. Enteric neuron myenteric (smooth mm) and submucosal (mucosa) e. Pudenal nerve external anal sphincter f. Haustral: SPMRM g. Gastrocolonic reflex i. Rapid long enteric motor neuron

ii. Slow gastrin smooth mm cell h. Control of sphincters i. Distention relaxes IAS; EAS relaxes with defecation is appropriate i. Storage of feces j. Defection i. Short, long, pudendal 7. VomitingVESTED