ABSTRACT Micro Osteo Perforation A new mantra to reduce treatment time The search for methods that decrease

se the treatment duration without compromising the outcome is a main challenge in orthodontic research. Micro Osteo Perforations significantly increased the expression of cytokines and chemokines known to recruit osteoclast precursors and stimulate osteoclast differentiation. Micro Osteo Perforations are an effective, comfortable, and safe procedure to accelerate tooth movement during orthodontic treatment. Micro Osteo Perforations could reduce orthodontic treatment time by 62%. Such newer techniques accelerate patient compliance and therefore accelerates the practice.