SUZUKI COUPLING REACTION

GUIDED BY DR. S. BANERJEE Asst. Prof

PRESENTED BY ARINDAM PATRA M.Sc 4th SeM

CONTENTS
Intoduction What is Suzuki Reaction? General reaction and mechanism Examples of Suzuki reaction

Advantages and Disadvantages

Introduction
The Suzuki reaction is the organic reaction that is classified as a coupling reaction where the coupling partners are a boronic acid with a halide catalyzed by a palladium(0) complex.
It was first published in 1979 by Akira Suzuki and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their effort for discovery and development of palladium-catalyzed cross couplings in organic synthesis. The general scheme for the Suzuki reaction is a carbon-carbon single bond by coupling a organoboron species (R1-BY2) with a halide (R2-X) using a palladium catalyst and a base

What is Suzuki reacton?

The Suzuki reaction is a palladium-catalyzed coupling of a vinyl or aryl halide (R'X) with an organoborane (RBY2) to form a product (RR') with a new CC bond. Pd(PPh3)4 is the typical palladium catalyst. The reaction is carried out in the presence of a base such as NaOH or NaOCH2CH3. The halogen is usually Br or I. The Suzuki reaction is completely stereospecific.

Reaction and mechanism

The Suzuki Reaction examples

Advantages of Suzuki reaction:

1.Mild reaction condition 2.Tolerance of activative functional group 3.insensitity to moisture 4.Low toxicity

Disadvantages of Suzuki reaction

1. Aryl chlorides are not usually not good substrates because they tend to react very slowly.