Predisposing factor: Inhalation of infected aerosol through droplet nuclei ( exposure to infected clients by coughing, sneezing and talking).

Lungs

Alveoli ( where bacteria deposited and multiply).

Spread through the lymphatic system.

Regional Lymph nodes

Body

Blood stream

Stimulates bodys immune response

Initiates systemic local inflammatory response

Go back to alveoli (where bacteria deposited and multiply).

Neutrophils and macrophages ( isolate and phagocytize bacteria).

Most primary tubercles heal by forming scars and calcify lesion ( ghon tubercles).

Necrotic degeneration

May contain bacilli that can be reactivated and cause secondary infection. Multiple drug resistance.

Produces cavity filled with cheese-like mass of tubercle bacilli, dead WBCs and necrotic lung tissues

Insertion of CTT

Medical management Drugs (no effects).

s/sx: low grade fever, fatigue, (+)hemoptysis , productive cough, night sweats, pallor, dyspnea, chest, pain, Elevated WBC