CHLOROQUINE (NGUYN TUN ANH)

1. Tn
Tn IUPAC: ()-N'-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine
Tn thng: Chloroquine
Tn khc: Resochin
2. Tnh cht vt l
KLPT: 319.872 g.mol-1
Nhit nng chy: 547,87K
Nhit si: 820,36 K at 760 mmHg

3. Tnh cht ha hc
CTPT: C18H26ClN3

CTCT:
4. Tc dng dc l
Cloroquin c tc dng tt trn cc th hng cu ca P. vivax, P. malariae v
hu ht cc chng P. falciparum(tr th giao t). C ch tc dng chng st rt cn
cha r nhng c th do thuc tc ng n qu trnh tiu ha haemoglobin bng
cch tng pH trong nang ca t bo k sinh trng st rt. Thuc cng cn tr s
tng hp nucleoprotein ca k sinh trng st rt. Thuc c th c ch mt s
enzym c l mt phn do tng tc vi DNA.
Dc ng hc
Cloroquin hp thu nhanh v gn nh hon ton ng tiu ha, ch c mt t l

nh c thy trong phn. Khong 55% thuc trong huyt tng lin kt vi cc
thnh phn khng khuch tn ca huyt tng. Cloroquin thi tr chm, nhng
tng ln khi nc tiu b acid ha. Mt lng thuc ng k tch t trong cc m.
ng vt, thuc tp trung nhiu bch cu, nng thuc trong gan, thn, lch
v phi cao gp 200 n 700 ln trong huyt tng. Trong khi no, ty sng
thuc tp trung ch cao gp 10 n 30 ln trong huyt tng. Cloroquin b thoi
ging trong c th, sn phm chuyn ha chnh l desethyl cloroquin (khong 1/4
hm lng cc cht thy c trong nc tiu). Mt dn cht ca acid carboxylic l
bisdesethylcloroquin v cc sn phm chuyn ha cho n nay cha xc nh c
c tnh cng c tm thy vi 1 lng nh trong nc tiu. Khong hn mt na
lng cloroquin thi tr qua ng nc tiu dng khng bin i. Cloroquin c
th tn lu nhiu thng hoc nhiu nm trong c th.