ABC Calc

Antibiotic Consumption Calculator. Version 3.1.

Suggested citation for this Excel application Monnet DL. ABC Calc - Antibiotic consumption calculator [Microsoft Excel application]. Version 3.1. Copenhagen (Denmark): Statens Serum Institut ; 2006. References Anatomical Therapeutic Chemical (ATC) classification index with Defined Daily Doses (DDDs). Oslo (Norway): WHO Collaborating Centre for Drug Statistics Methodology

ABC Calc now provides feed-back of results by individual antibacterial agent and route of adminis To achieve this, a new procedure for inserting rows in the "Enter consumption data" folder was in After selecting a row to be copied and copying this row, one must stay on the same row and insert This is different from versions of ABC Calc prior to version 3.0. Failure to use this new procedure will result in calculations errors when using ABC Calc 3.1.

Capell D. Descriptive tools and analysis. In: Dukes MNG, editor. Drug utilization studies. Methods and us Copenhagen (Denmark): WHO Regional Office for Europe; 1993. p. 55-78.

Acknowledgements The author is grateful to Marit Rnning & Hege Salvesen Blix (WHO Collaborating Centre for Drug Statist Oslo, Norway) for providing the updated definitions of DDDs and constructive remarks, to Stephanie Nats Medical Center Nijmegen, Nijmegen, The Netherlands), Catherine Billon (Centre Hospitalier de Versailles & John M. Stelling (WHO Collaborating Centre for Surveillance of Antimicrobial Resistance, Microbiology and Women's Hospital, Boston MA, USA) who provided helpful comments about the first version of this a and to Fiona M. MacKenzie (ARPAC project, Aberdeen Royal Infirmary, Aberdeen, Scotland), Robert Van (ESAC project, Antwerp University, Wilrijk, Belgium), Peter Zarb (St. Luke's Hospital, G'Mangia, Malta), and all users of versions 1 and 2 whose suggestions helped to further improve this Excel application.

C Calc

tion Calculator. Version 3.1.

ual antibacterial agent and route of administration. the "Enter consumption data" folder was introduced. w, one must stay on the same row and insert the copied cells.

ions errors when using ABC Calc 3.1.

Microsoft Excel application]. Version 3.1.

x with Defined Daily Doses (DDDs). ; 2006.

editor. Drug utilization studies. Methods and uses.

lix (WHO Collaborating Centre for Drug Statistics Methodology, s and constructive remarks, to Stephanie Natsch (University therine Billon (Centre Hospitalier de Versailles, Le Chesnay, France), ance of Antimicrobial Resistance, Microbiology Department, Brigham lpful comments about the first version of this application, yal Infirmary, Aberdeen, Scotland), Robert Vander Stichele, Matus Ferech Zarb (St. Luke's Hospital, G'Mangia, Malta), d to further improve this Excel application.

Introduction to ABC Calc

ABC Calc was developed at the National Center for Antimicrobials and Infection Control, as part of the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANM European Study Group on Antibiotic Policies (ESGAP) to help members of the microbiology and infect antibiotic consumption in hospitals and hospitalization units. It is a simple tool that transforms data provide (generally as a number of packages) into meaningful antibiotic consumption rates.

As recommended by the World Health Organization (WHO), ABC Calc reports consumption as a number per 100 bed-days. For a specific drug, the DDD corresponds to the assumed average daily dose for its ma DDDs are assigned by the WHO Collaborating Centre for Drug Statistics Methodology ABC Calc uses the latest update, i.e. the ATC/DDD Index 2006 setting, they should NOT be modified, in order to allow comparisons among hospitals.

ABC Calc now provides feed-back of results by individual antibacterial agent and route of adminis To achieve this, a new procedure for inserting rows in the "Enter consumption data" folder was in After selecting a row to be copied and copying this row, one must stay on the same row and insert This is different from versions of ABC Calc prior to version 3.0. Failure to use this new procedure will result in calculations errors when using ABC Calc 3.1.

At present, ABC Calc only deals with "Antibacterials for systemic use" also known as group J01 of the AT antibacterials in the following ATC groups: A02BD (Combinations for eradication of Helicobacter pylori ), A incl. For selective decontamination of the digestive tract), J04A (Drugs for treatment of tuberculosis) and P and other protozoal diseases). Antibiotics for topical use, which are found in other ATC groups, are exclu Additionally, ABC Calc cannot deal with several antibiotic combinations, mainly because DDDs have not b Before a solution is found to this problem, we nevertheless encourage users to record information on spec combinations to help identify the ones that are used in hospitals. Despite its limitations, we hope that ABC Calc will help collect antibiotic consumption data from hospitals and increase awareness about antibiotic misuse in hospitals. Comments and suggestions are welcomed and can be sent to Dominique L. Monnet at:

er for Antimicrobials and Infection Control, Statens Serum Institut (Copenhagen, Denmark) l Resistance Monitoring and Research Programme (DANMAP) and as one of the activities of the to help members of the microbiology and infectious disease community calculate alization units. It is a simple tool that transforms data provided by hospital pharmacies ningful antibiotic consumption rates.

zation (WHO), ABC Calc reports consumption as a number of Defined Daily Doses (DDD) D corresponds to the assumed average daily dose for its main indication in adults. ing Centre for Drug Statistics Methodology (Oslo, Norway) and updated once a year. . Although DDDs might not reflect daily doses used in practice in a specific to allow comparisons among hospitals.

s by individual antibacterial agent and route of administration. ing rows in the "Enter consumption data" folder was introduced. ying this row, one must stay on the same row and insert the copied cells. prior to version 3.0. t in calculations errors when using ABC Calc 3.1.

erials for systemic use" also known as group J01 of the ATC classification system, as well as 2BD (Combinations for eradication of Helicobacter pylori ), A07AA (Intestinal antiinfectives, stive tract), J04A (Drugs for treatment of tuberculosis) and P01A (Agents against amoebiasis topical use, which are found in other ATC groups, are excluded. al antibiotic combinations, mainly because DDDs have not been defined for these combinations. nevertheless encourage users to record information on specialties consisting in antibiotic will help collect antibiotic consumption data from hospitals in Europe and worldwide, dom@ssi.dk

d can be sent to Dominique L. Monnet at:

Note: These instructions assume a basic knowledge of Excel, including "Save as", "Copy" and "Insert copied cells" fun Users who are not familiar with Microsoft Excel should seek help before entering data.

The method for inserting rows in the "Enter consumption data" folder has changed (as compared to versions After selecting a row to be copied and copying this row, one must stay on the same row and insert the copied Please see below for detailed instructions. Failure to use this new procedure will result in calculations errors when using ABC Calc 3.1.

Instructions
1. 2. Save the file ABC Calc 3.1.xls under a new name ("Save as"), e.g. myABdata.xls, then open this new file.

Go to "Enter consumption data" and enter the names of all antibiotic products stored by the pharmacy and their corres number of grams per unit dose and number of unit doses per package. When given in another unit, convert to grams (e 1 million international units (or MIU or MU) benzylpenicillin correspond to 0.6 grams. If a vial of benzylpenicillin contain then the number of grams per unit dose is 3).

Definitions

Unit dose. Depending on the product, a unit dose corresponds to one tablet, one gelcap, one vial of infusion solution In some instances, users might want to use a volume as a unit dose, e.g. 1 ml infusion solution, 1 ml mixture, etc.

Package. Depending on the product, a package corresponds to, for example, a box of 10 tablets, a bag of 500 tablets In some instances, the package may be equal to the unit dose, e.g. if vials of infusion solution are distributed individu the number of unit doses per package is 1.

Name of product
AMOX 500 mg GEL

Grams per unit dose

Nr. unit doses per package

0.5

100

3.

If there is a second product for the same antibiotic name and route of administration: - select the corresponding row (number on the left, e.g. below "48")

Name of product
AMOX 500 mg GEL

Grams per unit dose

Nr. unit doses per package

0.5

100

- copy this row ("Edit" then "Copy") - stay on this row and insert the copied row ("Insert" then "Copied cells").

Name of product
AMOX 500 mg GEL AMOX 500 mg GEL

Grams per unit dose

Nr. unit doses per package

0.5 0.5

100 100

IMPORTANT NOTE: Failure to insert rows as mentioned above will result in calculations errors when using AB - finally, replace/correct the information about the second product for this antibiotic and route of administration.

Name of product
AMOX 500 mg GEL AMOX 1000mg GEL

Grams per unit dose

Nr. unit doses per package

0.5 1

100 20

IMPORTANT NOTE: As a rule, USERS MUST ONLY WORK WITH WHITE CELLS in ABC Calc. Grey cells must NOT be modified because they contain reference information or formulas. Continue until the whole list of products, grams per unit dose and number of unit doses per package is complete.

4.

Enter the number of packages of each product which has been consumed during the study period as in the example be This will automatically calculate the number of grams (or MU) (column N) and the number of DDDs (column O) used du

Name of product
AMOX 500 mg GEL AMOX 1000mg GEL

Grams per unit dose

Nr. unit doses per package

0.5 1

100 20

Continue until the whole list of number of packages consumed is complete.

5.

Finally, go to "Enter hospital data-Get results" and enter information on hospital activity. Make sure that this information is collected for the same hospitalization units and patient types as for antibioti This information can be entered: - either as the number of beds, the occupancy index (e.g., enter 0.85 if 85% of beds where occupied during the study

the number of days during the study period. ABC Calc will automatically calculate the number of bed-days using the Nr. bed-days (during a specific period) = Nr. beds x Occupancy index x Nr. days (during that period)

- or directly as the number of bed-days if readily available. A bed-day corresponds to one occupied hospital bed during The days of admission and discharge are usually counted together as one bed-day.

After calculation or entry of the number of bed-days, ABC Calc will automatically calculate overall consumption of antib and consumption of various classes of antibiotics as a number of grams per 100 bed-days (column L) and as a numbe DDD per 100 bed-days (column M).

asic knowledge of Excel, including "Save as", "Copy" and "Insert copied cells" functions. h Microsoft Excel should seek help before entering data.

the "Enter consumption data" folder has changed (as compared to versions of ABC Calc prior to version 3.0). and copying this row, one must stay on the same row and insert the copied cells. will result in calculations errors when using ABC Calc 3.1.

a new name ("Save as"), e.g. myABdata.xls, then open this new file.

enter the names of all antibiotic products stored by the pharmacy and their corresponding umber of unit doses per package. When given in another unit, convert to grams (e.g., r MU) benzylpenicillin correspond to 0.6 grams. If a vial of benzylpenicillin contains 5 MU,

ct, a unit dose corresponds to one tablet, one gelcap, one vial of infusion solution, one vial of mixture, etc. t to use a volume as a unit dose, e.g. 1 ml infusion solution, 1 ml mixture, etc.

t, a package corresponds to, for example, a box of 10 tablets, a bag of 500 tablets or a box of 12 vials, etc. y be equal to the unit dose, e.g. if vials of infusion solution are distributed individually. In this case,

Name of antibacterial
Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin

ATC code
J01CA04 J01CA04 J01CA06

Adm. route
O P O

DDD Nr. DDD (WHO per 2006) U package

1 g 1 g 1.2 g 50.0 0.0 0.0

same antibiotic name and route of administration:

ber on the left, e.g. below "48")

Name of antibacterial
Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin

ATC code
J01CA04 J01CA04 J01CA06

Adm. route
O P O

DDD Nr. DDD (WHO per 2006) U package

1 g 1 g 1.2 g 50.0 0.0 0.0

ed row ("Insert" then "Copied cells").

Name of antibacterial
Amoxicillin (Oral) Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin

ATC code
J01CA04 J01CA04 J01CA04 J01CA06

Adm. route
O O P O

DDD Nr. DDD (WHO per 2006) U package

1 g 1 g 1 g 1.2 g 50.0 50.0 0.0 0.0

rt rows as mentioned above will result in calculations errors when using ABC Calc 3.1

on about the second product for this antibiotic and route of administration.

Name of antibacterial
Amoxicillin (Oral) Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin

ATC code
J01CA04 J01CA04 J01CA04 J01CA06

Adm. route
O O P O

DDD Nr. DDD (WHO per 2006) U package

1 g 1 g 1 g 1.2 g 50.0 20.0 0.0 0.0

RS MUST ONLY WORK WITH WHITE CELLS in ABC Calc. because they contain reference information or formulas.

cts, grams per unit dose and number of unit doses per package is complete.

h product which has been consumed during the study period as in the example below. umber of grams (or MU) (column N) and the number of DDDs (column O) used during the period.

Name of antibacterial
Amoxicillin (Oral) Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin

ATC code
J01CA04 J01CA04 J01CA04 J01CA06

Adm. route
O O P O

DDD Nr. DDD (WHO per 2006) U package

1 g 1 g 1 g 1.2 g 50.0 20.0 0.0 0.0

er of packages consumed is complete.

t results" and enter information on hospital activity. collected for the same hospitalization units and patient types as for antibiotics.

ccupancy index (e.g., enter 0.85 if 85% of beds where occupied during the study period) and

y period. ABC Calc will automatically calculate the number of bed-days using the formula:

specific period) = Nr. beds x Occupancy index x Nr. days (during that period)

ys if readily available. A bed-day corresponds to one occupied hospital bed during one day. ge are usually counted together as one bed-day.

er of bed-days, ABC Calc will automatically calculate overall consumption of antibacterials of antibiotics as a number of grams per 100 bed-days (column L) and as a number of

Nr. packages

Nr. grams
0.0 0.0 0.0

Nr. DDD
0.0 0.0 0.0

Nr. packages

Nr. grams
0.0 0.0 0.0

Nr. DDD
0.0 0.0 0.0

Nr. packages

Nr. grams
0.0 0.0 0.0 0.0

Nr. DDD
0.0 0.0 0.0 0.0

Nr. packages

Nr. grams
0.0 0.0 0.0 0.0

Nr. DDD
0.0 0.0 0.0 0.0

Nr. packages 25 10

Nr. grams
1250.0 200.0 0.0 0.0

Nr. DDD
1250.0 200.0 0.0 0.0

antibacterials, Penicillins J01C - Beta-lactam 0

J 0 Without anti-pseudomonal activity

J01A - Tetracyclines

Name of product
Grams per unit dose Nr. unit doses per package

J 0

J 0

J 0 With anti-pseudo. act.

Other With

J Without

J01D - Other beta-lactam antibact

J 0 J 0 J0 1

J01E - Sulfonamides and trimethoprim

J 0 J
J0 1E J 0 J 0

J 0

J01G - Aminoglycoside antib.

J 0

J01F - Macrolides, lincosamides and streptogramins

J 0
J 0

J 0

J 0

J 0

J01M - Quinolone antibacterials

J 0

J 0

Antibacterials in ATC groups other than J01, excl. topical use

J 0
J 0

antibacterials J01X - Other J01R

J 0 J 0

J 0

J 0

J 0

Name of antibacterial
Demeclocycline Doxycyline (Oral) Doxycyline (Parenteral) Chlortetracycline Lymecycline (Oral) Lymecycline (Parenteral) Metacycline Oxytetracycline (Oral) Oxytetracycline (Parenteral) Tetracycline (Oral) Tetracycline (Parenteral) Minocycline (Oral) Minocycline (Parenteral) Rolitetracycline Penimepicycline Clomocycline
Tetra. + chlortet. + demeclo. (115.4:115.4:69.2)

ATC code
J01AA01 J01AA02 J01AA02 J01AA03 J01AA04 J01AA04 J01AA05 J01AA06 J01AA06 J01AA07 J01AA07 J01AA08 J01AA08 J01AA09 J01AA10 J01AA11 J01AA20 J01AA20 J01AA56 J01BA01 J01BA01 J01BA02 J01BA02 J01CA01 J01CA01 J01CA01 J01CA02 J01CA04 J01CA04 J01CA06 J01CA07 J01CA07 J01CA08 J01CA11 J01CA14 J01CA14 J01CA15 J01CA17 J01CA18

Adm. route
O O P O O P O O P O P O P P O O

DDD (WHO 2006) U

0.6 g 0.1 g 0.1 g 1 g 0.6 g 0.6 g 0.6 g 1 g 1 g 1 g 1 g 0.2 g 0.2 g 0.35 g 1 g 0.6 g

Nr. DDD per package 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Comb. of tetracyclines (other) Oxytetracycline, combinations Chloramphenicol (Oral) Chloramphenicol (Parenteral) Thiamphenicol (Oral) Thiamphenicol (Parenteral) Ampicillin (Oral) Ampicillin (Parenteral) Ampicillin (Rectal) Pivampicillin Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin Epicillin (Oral) Epicillin (Parenteral) Pivmecillinam Mecillinam Metampicillin (Oral) Metampicillin (Parenteral) Talampicillin Temocillin Hetacillin

O P O P O P R O O P O O P O P O P O P O

3 g 3 g 1.5 g 1.5 g 2 g 2 g 2 g 1.05 g 1 g 1 g 1.2 g 2 g 2 g 0.6 g 1.2 g 1.5 g 1.5 g 2 g 2 g 2 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Pivampi. + pivmecillinam (250:200, 125:100)

J01CA20 J01CA20 J01CA51 J01CA03 J01CA05 J01CA09 J01CA10 J01CA12 J01CA13 J01CA16 J01CA20 J01CE01 J01CE02 J01CE03 J01CE04 J01CE05 J01CE06 J01CE07 J01CE08 J01CE09 J01CE10 J01CE30 J01CE30 J01CE30 J01CF01 J01CF01 J01CF02 J01CF02 J01CF03 J01CF04 J01CF04 J01CF05 J01CF05

1.35 g

0.0

Combinations (other) Ampicillin, combinations Carbenicillin Carindacillin Azlocillin Mezlocillin Piperacillin Ticarcillin Sulbenicillin Combinations Benzylpenicillin Phenoxymethylpenicillin Propicillin Azidocillin Pheneticillin Penamecillin Clometocillin Benzathine benzylpenicillin Procaine penicillin Benzathine phenoxymethylpenicillin
Procaine pen. + benzylpen. (1800:360) Benzylpen. + Procaine pen. + Benzathine pen.

P O P P P P P P O O O O O O P P O P P O P O P P O P O P

12 g 4 g 12 g 6 g 14 g 15 g 15 g 3.6 g 2 g 0.9 g 1.5 g 1 g 1.05 g 1 g 3.6 g 0.6 g 2 g 2.16 g 3.6 g 2 g 2 g 2 g 2 g 4 g 2 g 2 g 2 g 2 g 1 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Combinations (other) Dicloxacillin (Oral) Dicloxacillin (Parenteral) Cloxacillin (Oral) Cloxacillin (Parenteral) Methicillin Oxacillin (Oral) Oxacillin (Parenteral) Flucloxacillin (Oral) Flucloxacillin (Parenteral) Sulbactam Tazobactam
Ampicillin and enzyme inhibitor (Parenteral) Amoxicillin and enzyme inhibitor (Oral) Amoxicillin and enzyme inhibitor (Parenteral) Sultamicillin (ampicillin and enzyme inh., Oral) Ticarcillin and enzyme inhibitor Piperacillin and enzyme inhibitor

J01CG01 P J01CG02 J01CR01 J01CR02 J01CR02 J01CR04 J01CR03 J01CR05 P O P O P P

2 g 1 g 3 g 1.5 g 15 g 14 g

0.0 0.0 0.0 0.0 0.0 0.0

Ampicillin + cloxacillin (250:250) (Oral) Ampicillin + cloxacillin (250:250) (Parenteral) Ampicillin + flucloxacillin (250:250) (Oral) Ampicillin + flucloxacillin (250:250) (Parenteral) Ampicillin + oxacillin (125:125) (Oral) Ampicillin + oxacillin (660:330) (Parenteral)
Combinations of penicillins (other)

J01CR50 J01CR50 J01CR50 J01CR50 J01CR50 J01CR50 J01CR50 J01DB01 J01DB02 J01DB03 J01DB04 J01DB05 J01DB06 J01DB07 J01DB08 J01DB09 J01DB09 J01DB10 J01DB11 J01DB12 J01DC01 J01DC02 J01DC02 J01DC03 J01DC04 J01DC05 J01DC06 J01DC07 J01DC08 J01DC09 J01DC10 J01DC11 J01DD01 J01DD02 J01DD03 J01DD04 J01DD05 J01DD06 J01DD07 J01DD08 J01DD09 J01DD10

O P O P O P O P P P O P O P O P

2 g 2 g 2 g 2 g 2 g 2 g 2 g 3 g 4 g 3 g 2 g 3 g 1 g 4 g 2 g 2 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Cefalexin Cefaloridine Cefalotin Cefazolin Cefadroxil Cefazedone Cefatrizine Cefapirin Cefradine (Oral) Cefradine (Parenteral) Cefacetrile Cefroxadine Ceftezole Cefoxitin Cefuroxime (Oral) Cefuroxime (Parenteral) Cefamandole Cefaclor Cefotetan Cefonicid Cefotiam Loracarbef Cefmetazole Cefprozil Ceforanide Cefotaxime Ceftazidime Cefsulodin Ceftriaxone Cefmenoxime Latamoxef Ceftizoxime Cefixime Cefodizime Cefetamet

P P O P P O P P P O O P P P P P P P P O P O

6 g 6 g 0.5 g 3 g 6 g 1 g 4 g 1 g 4 g 0.6 g 1 g 4 g 4 g 4 g 4 g 2 g 2 g 4 g 4 g 0.4 g 2 g 1 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Cefpiramide Cefoperazone Cefpodoxime Ceftibuten Cefdinir Cefditoren Ceftriaxone, combinations Cefoperazone, combinations Cefepime Cefpirome Aztreonam Meropenem Ertapenem Imipenem and enzyme inhibitor Trimethoprim (Oral) Trimethoprim (Parenteral) Brodimoprim Sulfaisodimidine (Oral) Sulfaisodimidine (Parenteral) Sulfamethizole Sulfadimidine Sulfapyridine Sulfafurazole (Oral) Sulfafurazole (Parenteral) Sulfanilamide Sulfathiazole Sulfathiourea Combinations Sulfamethoxazole Sulfadiazine Sulfamoxole (Oral) Sulfamoxole (Parenteral)
Sulfacarbamide+Sulfadiaz.+Sulfadimid. (167:167:167)

J01DD11 J01DD12 J01DD13 J01DD14 J01DD15 J01DD16 J01DD54 J01DD62 J01DE01 J01DE02 J01DF01 J01DH02 J01DH03 J01DH51 J01EA01 J01EA01 J01EA02 J01EB01 J01EB01 J01EB02 J01EB03 J01EB04 J01EB05 J01EB05 J01EB06 J01EB07 J01EB08 J01EB20 J01EC01 J01EC02 J01EC03 J01EC03 J01EC20 J01EC20 J01ED01 J01ED02 J01ED03 J01ED04 J01ED05 J01ED06

P P O O O

2 g 4 g 0.4 g 0.4 g 0.6 g

0.0 0.0 0.0 0.0 0.0

P P P P P P O P O O P O O O O P

2 g 4 g 4 g 2 g 1 g 2 g 0.4 g 0.4 g 0.2 g 4 g 4 g 4 g 4 g 1 g 4 g 4 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

O O O O P O O O O O O

6 g 2 g 0.6 g 1 g 1 g 2 g 0.5 g 0.1 g 0.5 g 0.5 g 0.5 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Combinations (other) Sulfadimethoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin

Sulfamerazine Sulfaphenazole Sulfamazone (Oral) Sulfamazone (Rectal) Combinations

Sulfamethox. + trimethoprim (40:8, 80:16) (Oral) Sulfamethox. + trimeth. (40:8, 80:16) (Parenteral) Sulfamethox. + trimeth. (oth. comb.) Sulfadiazine + trimeth. (205:45, 410:90) Sulfametrole + trimethoprim (800:160) (Oral) Sulfametrole + trimeth. (800:160) (Parenteral) Sulfamoxole and trimethoprim Sulfadimidine and trimethoprim Sulfadiazine + tetroxoprim (250:100) Sulfamerazine + trimethoprim (120:80)

J01ED07 J01ED08 J01ED09 J01ED09 J01ED20 J01EE01 J01EE01 J01EE01 J01EE02 J01EE03 J01EE03 J01EE04 J01EE05 J01EE06 J01EE07 J01FA01 J01FA01 J01FA01 J01FA02 J01FA03 J01FA05 J01FA06 J01FA07 J01FA08 J01FA09 J01FA09 J01FA10 J01FA10 J01FA11 J01FA12 J01FA13 J01FA14 J01FA15 J01FF01 J01FF01 J01FF02 J01FF02 J01FG01 J01FG02 J01GA01 J01GA02

O O O R O P O O P

3 g 1 g 1.5 g 1.5 g 1.92 g 1.92 g 1 g 1.92 g 1.92 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

O O O O P O P O O O O O P O P O O O O O O P O P O P P P

0.7 g 0.8 g 1 g 2 g 1 g 3 g 1 g 1 g 0.3 g 2 g 1 g 0.5 g 1 g 0.3 g 0.5 g 1.2 g 0.8 g 0.5 g 0.75 g 0.8 g 1.2 g 1.8 g 1.8 g 1.8 g 2 g 1.5 g 1 g 1 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Erythromycin (Oral) Erythromycin ethylsuccinate tabl. (Oral) Erythromycin (Parenteral) Spiramycin Midecamycin Oleandomycin Roxithromycin Josamycin Troleandomycin Clarithromycin (Oral) Clarithromycin (Parenteral) Azithromycin (Oral) Azithromycin (Parenteral) Miocamycin Rokitamycin Dirithromycin Flurithromycin Telithromycin Clindamycin (Oral) Clindamycin (Parenteral) Lincomycin (Oral) Lincomycin (Parenteral) Pristinamycin Quinupristin/dalfopristin Streptomycin (Parenteral) Streptoduocin

Tobramycin (Parenteral) Tobramycin (Inhal. sol.) Gentamicin (Parenteral) Gentamicin (Bead chain) Kanamycin (Parenteral) Neomycin (Oral) Amikacin Netilmicin (Oral) Netilmicin (Parenteral) Sisomicin Dibekacin Ribostamycin Isepamicin Ofloxacin (Oral) Ofloxacin (Parenteral) Ciprofloxacin (Oral) Ciprofloxacin (Parenteral) Pefloxacin (Oral) Pefloxacin (Parenteral) Enoxacin Temafloxacin Norfloxacin Lomefloxacin Fleroxacin (Oral) Fleroxacin (Parenteral) Sparfloxacin Rufloxacin Grepafloxacin Levofloxacin (Oral) Levofloxacin (Parenteral) Trovafloxacin (Oral) Trovafloxacin (Parenteral) Moxifloxacin (Oral) Moxifloxacin (Parenteral) Gemifloxacin Gatifloxacin (Oral) Gatifloxacin (Parenteral) Prulifloxacin Rosoxacin Nalidixic acid Piromidic acid Pipemidic acid

J01GB01 P J01GB01 Inh. sol. J01GB03 P J01GB03 J01GB04 P J01GB05 O J01GB06 P J01GB07 O J01GB07 P J01GB08 P J01GB09 P J01GB10 J01GB11 J01MA01 O J01MA01 P J01MA02 O J01MA02 P J01MA03 O J01MA03 P J01MA04 O J01MA05 O J01MA06 O J01MA07 J01MA08 O J01MA08 P J01MA09 O J01MA10 O J01MA11 O J01MA12 O J01MA12 P J01MA13 O J01MA13 P J01MA14 O J01MA14 P J01MA15 J01MA16 O J01MA16 P J01MA17 J01MB01 O J01MB02 O J01MB03 O J01MB04 O

0.24 g 0.3 g 0.24 g 0.24 g 1 g 1 g 1 g 0.35 g 0.35 g 0.24 g 0.14 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.4 g 0.4 g 1 g 0.5 g 0.8 g 0.8 g 0.8 g 0.8 g 0.8 g 0.4 g 0.4 g 0.2 g 0.2 g 0.4 g 0.5 g 0.5 g 0.2 g 0.2 g 0.4 g 0.4 g 0.4 g 0.4 g 0.3 g 4 g 2 g 0.8 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Oxolinic acid Cinoxacin Flumequine

Penicillins, comb. with other antibacterials Sulfonamides, comb. (excl. trimethoprim) Cefuroxime, comb. with other antibacterials Spiramycin, comb. with other antibacterials

J01MB05 O J01MB06 O J01MB07 O J01RA01 J01RA02 J01RA03 J01RA04 J01XA01 J01XA02 J01XB01 J01XB01 J01XB02 J01XC01 J01XC01 J01XD01 J01XD02 J01XD03 J01XE01 J01XE02 J01XX01 J01XX01 J01XX02 J01XX03 J01XX04 J01XX05 J01XX05 J01XX06 J01XX07 J01XX08 J01XX08 A02BD01 A02BD02 A02BD03 A02BD04 O A02BD05 O A02BD06 O A07AA01 O A07AA04 R P O O O O O P P P P
Inh. sol.

1 g 1 g 1.2 g

0.0 0.0 0.0

Vancomycin (Parenteral) Teicoplanin Colistin (Parenteral) Colistin (Inhal. sol.) Polymyxin B (Parenteral) Fusidic acid (Oral) Fusidic acid (Parenteral) Metronidazole (Parenteral) Tinidazole (Parenteral) Ornidazole (Parenteral) Nitrofurantoin Nifurtoinol Fosfomycin (Parenteral) Fosfomycin (Oral) Xibornol Clofoctol Spectinomycin Methenamine, hippurate Methenamine, mandelate Mandelic acid Nitroxoline Linezolid (Oral) Linezolid (Parenteral)
Omeprazole, amoxicillin, metronidazole Lanzoprazole, tetracycline, metronidazole Lanzoprazole, amoxicillin, metronidazole Pantoprazole, amoxicillin, clarithromycin Omeprazole, amoxicillin, clarithromycin Esomeprazole, amoxicillin, clarithromycin

2 g 0.4 g 3 MU 3 MU 0.15 g 1.5 g 1.5 g 1.5 g 1.5 g 1 g 0.2 g 0.16 g 8 g 3 g 1.5 g 3 g 2 g 3 g 12 g 1 g 1.2 g 1.2 g

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

P O P P P P O O P O

6 tabl 6 tabl 6 tabl 5 g

0.0 0.0 0.0 0.0

Neomycin (Intestinal) Streptomycin (Intestinal)

Polymyxin B (Intestinal) Kanamycin (Intestinal) Vancomycin (Intestinal) Colistin (Intestinal) Rifaximin (Intestinal) Neomycin, combinations Streptomycin, combinations Rifampicin (Oral) Rifampicin (Parenteral) Rifamycin Rifabutin Metronidazole (Oral) Metronidazole (Rectal) Tinidazole (Oral) Tinidazole (Rectal) Ornidazole (Oral) Azanidazole Propenidazole Nimorazole Secnidazole

A07AA05 A07AA08 A07AA09 O A07AA10 A07AA11 A07AA51 A07AA54 J04AB02 J04AB02 J04AB03 J04AB04 O P P O 0.6 g 0.6 g 0.6 g 0.15 g 2 g 2 g 2 g 2 g 1.5 g 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2 g 0.0

P01AB01 O P01AB01 R P01AB02 O P01AB02 R P01AB03 O P01AB04 P01AB05 P01AB06 O P01AB07

2 g

0.0

Nr. packages

Nr. grams
0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Nr. DDD
0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0

0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0

0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0

Nr. beds Occupancy index (during study period) Nr. days (during study period) OR Nr. bed-days 0

Antibacterial use, by ATC level 2 to 4

ATC level 2 ATC ATC level 3 level 4 Additional level of subdivision ATC (not defined by the official level 5 ATC classification system) Nr. grams 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Nr. DDD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01 - Antibacterials for systemic use (Total) J01A - Tetracyclines J01B - Amphenicols J01C - Beta-lactam antibacterials, Penicillins
J01CA - Penicillins with extended spectrum (PES) PES without anti-pseudomonal activity PES with anti-pseudomonal activity J01CE - Beta-lactamase sensitive penicillins J01CF - Beta-lactamase resistant penicillins J01CG - Beta-lactamase inhibitors J01CR - Comb. of penicillins (incl. beta-lactamase inhibitors) PES without anti-pseudomonal activity + beta-lactamase inhibitors PES with anti-pseudomonal activity + beta-lactamase inhibitors Other combinations of penicillins

J01D - Other beta-lactam antibacterials

J01DB, J01DC, J01DD & J01DE - Cephalosporins J01DB - First-generation cephalosporins J01DC - Second-generation cephalosporins J01DD - Third-generation cephalosporins J01DE - Fourth-generation cephalosporins J01DF - Monobactams J01DH - Carbapenems

J01E - Sulfonamides and trimethoprim

J01EA - Trimethoprim and derivatives J01EB, J01EC & J01ED - Sulfonamides J01EB - Short-acting sulfonamides J01EC - Intermediate-acting sulfonamides J01ED - Long-acting sulfonamides J01EE - Combinations of sulfonamides and trimethoprin, incl. deriv.

J01F - Macrolides, lincosamides and streptogramins

J01FA - Macrolides J01FF - Lincosamides J01FG - Streptogramins

J01G - Aminoglycoside antibacterials

J01GA - Streptomycins J01GB - Other aminoglycosides

J01M - Quinolones antibacterials

J01MA - Fluoroquinolones J01MB - Other quinolones

J01X - Other antibacterials

J01XA - Glycopeptide antibacterials J01XB - Polymyxins J01XC - Steroid antibacterials J01XD - Imidazole derivatives J01XE - Nitrofuran derivatives J01XX - Other antibacterials

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Antibacterials in ATC groups other than J01, excl. topical use (Total)

0.0

0.0

Detailed antibacterial use, by ATC level 5 and route of administration

ATC level 5
J01AA01 J01AA02 J01AA02 J01AA03 J01AA04 J01AA04 J01AA05 J01AA06 J01AA06 J01AA07 J01AA07 J01AA08 J01AA08 J01AA09 J01AA10 J01AA11 J01AA20 J01AA20 J01AA56 J01BA01 J01BA01 J01BA02 J01BA02

Route Name
O O P O O P O O P O P O P P O O O P O P

Demeclocycline Doxycycline (Oral) Doxycycline (Parenteral) Chlortetracycline Lymecycline (Oral) Lymecycline (Parenteral) Metacycline Oxytetracycline (Oral) Oxytetracycline (Parenteral) Tetracycline (Oral) Tetracycline (Parenteral) Minocycline (Oral) Minocycline (Parenteral) Rolitetracycline Penimepicycline Clomocycline Tetra. + chloret. + demeclo. (115.4:115.4:69.2) Comb. of tetracyclines (other) Oxytetracycline, combinations Chlroramphenicol (Oral) Chloramphenicol (Parenteral) Thiamphenicol (Oral) Thiamphenicol (Parenteral)

Nr. grams 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Nr. DDD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0

J01CA01 J01CA01 J01CA01 J01CA02 J01CA04 J01CA04 J01CA06 J01CA07 J01CA07 J01CA08 J01CA11 J01CA14 J01CA14 J01CA15 J01CA17 J01CA18 J01CA20 J01CA20 J01CA51 J01CA03 J01CA05 J01CA09 J01CA10 J01CA12 J01CA13 J01CA16 J01CA20 J01CE01 J01CE02 J01CE03 J01CE04

O P R O O P O O P O P O P O P O O P O P P P P P P O O O

Ampicillin (Oral) Ampicillin (Parenteral) Ampicillin (Rectal) Pivampicillin Amoxicillin (Oral) Amoxicillin (Parenteral) Bacampicillin Epicillin (Oral) Epicillin (Parenteral) Pivmecillinam Mecillinam Metampicillin (Oral) Metampicillin (Parenteral) Talampicillin Temocillin Hetacillin Pivampi. + pivmecillinam (250:200, 125:100) Combinations (other) Ampicillin, combinations Carbenicillin Carindacillin Azlocillin Mezlocillin Piperacillin Ticarcillin Sulbenicillin Combinations Benzylpenicillin Phenoxymethylpenicillin Propicillin Azidocillin

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01CE05 J01CE06 J01CE07 J01CE08 J01CE09 J01CE10 J01CE30 J01CE30 J01CE30 J01CF01 J01CF01 J01CF02 J01CF02 J01CF03 J01CF04 J01CF04 J01CF05 J01CF05 J01CG01 J01CG02 J01CR01 J01CR02 J01CR02 J01CR04 J01CR03 J01CR05 J01CR50 J01CR50 J01CR50 J01CR50 J01CR50

O O O P P O P P O P O P P O P O P P P O P O P P O P O P O

Pheneticillin Penamecillin Clometocillin Benzathine benzylpenicillin Procaine penicillin Benzathine phenoxymethylpenicillin Procaine pen.+benzylpen.(1800:360) Benzylpenicillin + procaine pen. + benzathine pen. Combinations (other) Dicloxacillin (Oral) Dicloxacillin (Parenteral) Cloxacillin (Oral) Cloxacillin (Parenteral) Methicillin Oxacillin (Oral) Oxacillin (Parenteral) Flucloxacillin (Oral) Flucloxacillin (Parenteral) Sulbactam Tazobactam Ampicillin and enzyme inhibitor (Parenteral) Amoxicillin and enzyme inhibitor (Oral) Amoxicillin and enzyme inhibitor (Parenteral) Sultamicillin (ampicillin and enzyme inh., Oral) Ticarcillin and enzyme inhibitor Piperacillin and enzyme inhibitor Ampicillin + cloxacillin (250:250) (Oral) Ampicillin + cloxacillin (250:250) (Parenteral) Ampicillin + flucloxacillin (250:250) (Oral) Ampicillin + flucloxacillin (250:250) (Parenteral) Ampicillin + oxacillin (125:125) (Oral)

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01CR50 J01CR50 J01DB01 J01DB02 J01DB03 J01DB04 J01DB05 J01DB06 J01DB07 J01DB08 J01DB09 J01DB09 J01DB10 J01DB11 J01DB12 J01DC01 J01DC02 J01DC02 J01DC03 J01DC04 J01DC05 J01DC06 J01DC07 J01DC08 J01DC09 J01DC10 J01DC11 J01DD01 J01DD02 J01DD03 J01DD04

P O P P P O P O P O P P P O P P O P P P O O P P P P P

Ampicillin + oxacillin (660:330) (Parenteral) Combinations of penicillins (other) Cefalexin Cefaloridine Cefalotin Cefazolin Cefadroxil Cefazedone Cefatrizine Cefapirin Cefradine (Oral) Cefradine (Parenteral) Cefacetrile Cefroxadine Ceftezole Cefoxitin Cefuroxime (Oral) Cefuroxime (Parenteral) Cefamandole Cefaclor Cefotetan Cefonicid Cefotiam Loracarbef Cefmetazole Cefprozil Ceforanide Cefotaxime Ceftazidime Cefsulodin Ceftriaxone

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01DD05 J01DD06 J01DD07 J01DD08 J01DD09 J01DD10 J01DD11 J01DD12 J01DD13 J01DD14 J01DD15 J01DD16 J01DD54 J01DD62 J01DE01 J01DE02 J01DF01 J01DH02 J01DH03 J01DH51 J01EA01 J01EA01 J01EA02 J01EB01 J01EB01 J01EB02 J01EB03 J01EB04 J01EB05 J01EB05 J01EB06

P P P O P O P P O O O P P P P P P O P O O P O O O O P -

Cefmenoxime Latamoxef Ceftizoxime Cefixime Cefodizime Cefetamet Cefpiramide Cefoperazone Cefpodoxime Ceftibuten Cefdinir Cefditoren Ceftriaxone, combinations Cefoperazone, combinations Cefepime Cefpirome Aztreonam Meropenem Ertapenem Imipenem and enzyme inhibitor Trimethoprim (Oral) Trimethoprim (Parenteral) Brodimoprim Sulfaisodimidine (Oral) Sulfaisodimidine (Parenteral) Sulfamethizole Sulfadimidine Sulfapyridine Sulfafurazole (Oral) Sulfafurazole (Parenteral) Sulfanilamide

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01EB07 J01EB08 J01EB20 J01EC01 J01EC02 J01EC03 J01EC03 J01EC20 J01EC20 J01ED01 J01ED02 J01ED03 J01ED04 J01ED05 J01ED06 J01ED07 J01ED08 J01ED09 J01ED09 J01ED20 J01EE01 J01EE01 J01EE01 J01EE02 J01EE03 J01EE03 J01EE04 J01EE05 J01EE06 J01EE07 J01FA01

O O O O P O O O O O O O O O R O P O O P O O O

Sulfathiazole Sulfathiourea Combinations Sulfamethoxazole Sulfadiazine Sulfamoxole (Oral) Sulfamoxole (Parenteral) Sulfacarbamide + Sulfadiaz.+Sulfadimid. (167:167:167) Combinations Sulfadimethoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone (Oral) Sulfamazone (Rectal) Combinations Sulfamethox. + trimethoprim (40:8, 80:16) (Oral) Sulfamethox. + trimethoprim (40:8, 80:16) (Parenteral) Sulfamethox. + trimeth. (oth. comb.) Sulfadiazine and trimethoprim (205:45, 410:90) Sulfametrole and trimethoprim (800:160) (Oral) Sulfametrole and trimethoprim (800:160) (Parenteral) Sulfamoxole and trimethoprim Sulfadimidine and trimethoprim Sulfadiazine and tetroxoprim (250:100) Sulfamerazine and trimethoprim (120:80) Erythromycin (Oral)

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0

0.0 0.0 0.0

J01FA01 J01FA01 J01FA02 J01FA03 J01FA05 J01FA06 J01FA07 J01FA08 J01FA09 J01FA09 J01FA10 J01FA10 J01FA11 J01FA12 J01FA13 J01FA14 J01FA15 J01FF01 J01FF01 J01FF02 J01FF02 J01FG01 J01FG02 J01GA01 J01GA02 J01GB01 J01GB01 J01GB03 J01GB03 J01GB04 J01GB05

Erythromycin ethylsuccinate tabl. (Oral) Erythromycin (Parenteral) O Spiramycin P Midecamycin O Oleandomycin O Roxithromycin O Josamycin O Troleandomycin O Clarithromycin (Oral) P Clarithromycin (Parenteral) O Azithromycin P Azithromycin O Miocamycin O Rokitamycin O Dirithromycin O Flurithromycin O Telithromycin O Clindamycin (Oral) P Clindamycin (Parenteral) O Lincomycin (Oral) P Lincomycin (Parenteral) O Pristinamycin P Quinupristin/dalfopristin P Streptomycin (Parenteral) P Streptoduocin P Tobramycin (Parenteral) Inh. sol. Tobramycin (Inhal. sol.) P Gentamicin (Parenteral) Gentamicin (Bead chain) P Kanamycin (Parenteral) O Neomycin (Oral)
O P

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01GB06 J01GB07 J01GB07 J01GB08 J01GB09 J01GB10 J01GB11 J01MA01 J01MA01 J01MA02 J01MA02 J01MA03 J01MA03 J01MA04 J01MA05 J01MA06 J01MA07 J01MA08 J01MA08 J01MA09 J01MA10 J01MA11 J01MA12 J01MA12 J01MA13 J01MA13 J01MA14 J01MA14 J01MA15 J01MA16 J01MA16

P O P P P O P O P O P O O O O P O O O O P O P O P O P

Amikacin Netilmicin (Oral) Netilmicin (Parenteral) Sisomicin Dibekacin Ribostamycin Isepamicin Ofloxacin (Oral) Ofloxacin (Parenteral) Ciprofloxacin (Oral) Ciprofloxacin (Parenteral) Pefloxacin (Oral) Pefloxacin (Parenteral) Enoxacin Temafloxacin Norfloxacin Lomefloxacin Fleroxacin (Oral) Fleroxacin (Parenteral) Sparfloxacin Rufloxacin Grepafloxacin Levofloxacin (Oral) Levofloxacin (Parenteral) Trovafloxacin (Oral) Trovafloxacin (Parenteral) Moxifloxacin (Oral) Moxifloxacin (Parenteral) Gemifloxacin Gatifloxacin (Oral) Gatifloxacin (Parenteral)

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01MA17 J01MB01 J01MB02 J01MB03 J01MB04 J01MB05 J01MB06 J01MB07 J01RA01 J01RA02 J01RA03 J01RA04 J01XA01 J01XA02 J01XB01 J01XB01 J01XB02 J01XC01 J01XC01 J01XD01 J01XD02 J01XD03 J01XE01 J01XE02 J01XX01 J01XX01 J01XX02 J01XX03 J01XX04 J01XX05 J01XX05

Prulifloxacin Rosoxacin O Nalidixic acid O Piromidic acid O Pipemidic acid O Oxolinic acid O Cinoxacin O Flumequine Penicillins, comb. with other antibacterials Sulfonamides, comb. (excl. trimethoprim) Cefuroxime, comb. with other antibacterials Spiramycin, comb. with other antibacterials P Vancomycin (Parenteral) P Teicoplanin P Colistin (Parenteral) Inh. sol. Colistin (Inhal. sol.) P Polymyxin B (Parenteral) O Fusidic acid (Oral) P Fusidic acid (Parenteral) P Metronidazole (Parenteral) P Tinidazole (Parenteral) P Ornidazole (Parenteral) O Nitrofurantoin O Nifurtoinol P Fosfomycin (Parenteral) O Fosfomycin (Oral) Xibornol R Clofoctol P Spectinomycin O Methenamine, hippurate O Methenamine, mandelate
O

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

J01XX06 J01XX07 J01XX08 J01XX08 A02BD01 A02BD02 A02BD03 A02BD04 A02BD05 A02BD06 A07AA01 A07AA04 A07AA05 A07AA08 A07AA09 A07AA10 A07AA11 A07AA51 A07AA54 J04AB02 J04AB02 J04AB03 J04AB04 P01AB01 P01AB01 P01AB02 P01AB02 P01AB03 P01AB04 P01AB05

O O O P O O O O O O P P O O R O R O -

Mandelic acid Nitroxoline Linezolid (Oral) Linezolid (Parenteral) Omeprazole, amoxicillin, metronidazole Lanzoprazole, tetracycline, metronidazole Lanzoprazole, amoxicillin, metronidazole Pantoprazole, amoxicillin, clarithromycin Omeprazole, amoxicillin, clarithromycin Esomeprazole, amoxicillin, clarithromycin Neomycin (Intestinal) Streptomycin (Intestinal) Polymyxin B (Intestinal) Kanamycin (Intestinal) Vancomycin (Intestinal) Colistin (Intestinal) Rifaximin (Intestinal) Neomycin, combinations Streptomycin, combinations Rifampicin (Oral) Rifampicin (Parenteral) Rifamycin Rifabutin Metronidazole (Oral) Metronidazole (Rectal) Tinidazole (Oral) Tinidazole (Rectal) Ornidazole (Oral) Azanidazole Propenidazole

0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0

0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

P01AB06 P01AB07

O -

Nimorazole Secnidazole

0.0 0.0

0.0

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