Tng quan v

Min dch hc & Vc-xin hc

Phn 1: Tng quan v Min dch hc

Min dch bm sinh

Min dch mc phi

Gii thiu v h min dch

M lympho trung tm

M lympho ngoi bin

i thc bo

T bo lympho

Khng th

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Min dch bm sinh v mc phi

Min dch bm sinh Min dch mc phi

Hng ro bo v u tin C ngay khi sinh ra Khng c hiu

Hng ro bo v th 2
c hun luyn c hiu

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Min dch bm sinh

Hng ro c-ha-sinh hc
Da, mng nhy

Cc yu t chng khun t nhin

Lysozyme

ng tiu ha, h hp

H thng b th
Cytokines

Cc t bo dit khun
T bo dit t nhin Neutrophils n bo v i thc bo
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Hin tng thc bo (Phagocytosis)

TB Thc bo Tc nhn gy bnh

1. Ha ng ng

2. Gn kt

3. Nut

5. Tiu ha

4. Git cht
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Min dch mc phi

Tr nh:
Ngi b mc bnh truyn nhim Phc hi Rt t khi b mc li bnh ny mt ln na

Tnh c hiu
Min dch i vi mt bnh s khng gip phng nga cc bnh khc

Tnh a dng
Chng ta c th c bo v min dch i vi nhiu bnh

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

C ch phn ng min dch mc phi

Min dch dch th
(MD trung gian khng th)

Min dch trung gian t bo

Sn xut ra cc t bo c hiu Chng li cc khng nguyn trong t bo

To thnh cc protein c hiu (khng th) Chng li cc khng nguyn tun hon trong dch th Trung gian qua lympho B (TB lympho T cng tham gia)

Trung gian qua t bo lympho-T

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

T bo Lympho
T bo mm trong ty xng

Trng thnh trong ty xng

Trng thnh trong tuyn c

T bo B-lympho

T-lympho TH /TC
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

S lu hnh ca t bo lympho
Tuyn c

Ty xng

Mu

L lch

Hch lympho

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

S tng sinh v tnh ca t bo lympho

B cha lympho cha trng thnh (mi t bo u khc nhau)

S kch thch t bo lympho c hiu theo khng nguyn

Cm cc t bo lympho (Tt c ging nhau)

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

p ng min dch v tr nh

T bo lympho c kch hot

Min dch trung gian khng th

Min dch trung gian t bo

Bm Bm T bo sn xut khng th TH TH T h tr

CTL CTL T c Tm

Tm

T bo B-nh

T bo T-nh

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

p ng MD nguyn pht v th pht

Th pht
Mc phn ng min dch

Nguyn pht

10 Tip xc ln u

20

30

40

50 Thi

gian

Tip xc ln sau

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001

p ng MD nguyn pht v th pht (tt)

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001

Vai tr ca min dch trung gian khng th (MD dch th)

Chng li cc tc nhn gy bnh bn ngoi t bo
Quan trng trong phng v chng li vi khun & vi rt trc khi chng xm nhp vo t bo Khng hiu qu i vi tc nhn gy bnh trong t bo

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

C ch ca MD trung gian khng th

T bo B c hot ha bi cc khng nguyn KHNG ph thuc lympho T
Khng nguyn

TB Lympho B

TB lympho B c hot ha
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

C ch ca MD qua khng th (tt)

T bo B c hot ha bi cc khng nguyn ph thuc lympho T

T bo trnh din khng nguyn

T bo lympho TH

T bo lympho B c hot ha
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001

C ch ca MD qua khng th (tt)

S tng sinh v bit ha t bo B
Tng sinh TB B-lympho c hot ha Khng th

T bo tng

TB B-lympho nh
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Chc nng ca khng th

Khng th Khng nguyn

Lin kt khng nguyn-khng th

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Chc nng ca khng th

y mnh s thc bo
Kch hot h b th

C
B th:
- Tn cng trc tip cc t bo vi khun - y mnh thc bo - Gia tng p ng min dch v vim

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Cu trc ca khng th
Khu vc gn kt khng nguyn

Khu vc chc nng (site effector functions)

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Cc loi khng th
IgM

IgG

IgD

IgE

IgA

Secretory IgA

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

S chuyn i khng th

Hm lng khng th

IgM

IgG

10

15

20

25

Ngy

Khng nguyn
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Vai tr ca min dch trung gian t bo

Quan trng trong bo v chng li cc nhim trng do vi rt

v cc nhim trng trong t bo do vi khun

V d: Mycobacterium tuberculosis, Salmonella typhi

Quan trng trong vic hnh thnh tr nh min dch iu ha phn ng min dch

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

C ch min dch trung gian t bo

Trnh din khng nguyn bi APCs
Khng nguyn

Mu khng nguyn (antigen fragment)

Phc hp lin kt mng (Membrane-bound Complex)

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

C ch min dch trung gian t bo (tt)

Trnh din khng nguyn v s hot ha t bo T lympho
Trnh din KN

T lympho c hot ha
T h tr (TH ) T bo T c (CTLs) T bo T nh
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

T bo T h tr (TH)
T bo T cha bit ha

TH1

TH2

Ch yu kch hot t bo T v Tng cng MD trung gian t bo

Ch yu kch hot t bo B v Tng cng MD trung gian khng th

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

T bo T c (CTLs)

Perforin

CTL

T bo ch

Granzymes (men c hiu dit t bo)

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

T bo T-nh
Tn ti lu di trong mu v cc m lympho
T bo nh

S lng nhiu (hng ngn/hng triu) Sn sng cho ln tip xc tip theo vi khng nguyn ca mnh

Do vy, phn ng min dich th pht

(khi c th tip xc vi chnh khng nguyn nhanh hn rt nhiu so vi

phn ng min dch nguyn pht

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Bo v chng vi khun
Bo v khng c hiu gip hn ch s xm nhp ca khng nguyn
Hng ro sinh hc, ha hc v c hc

S thc bo hn ch s tng sinh ca vi khun Bo v mc phi ng gp s bo v c hiu tip theo

c bit thng qua min dch trung gian khng th
Trung ha cc c t

Thc y qu trnh thc bo

Kch hot h b th
1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Bo v chng li virt
Bo v khng c hiu hn ch s xm nhp Interferons (cytokines) hn ch s tng sinh

Min dch mc phi cung cp s bo v c hiu tip theo

Min dch trung gian khng th c th ngn chn s lan rng ca vi rt Min dch trung gian t bo c th tiu dit cc t bo ch b nhim bnh

1. Natural & Adaptive Immune Mechanisms. In: Playfair JHL. Immunology at a Glance. Oxford: Blackwell Scientific Publications; 1992 2. Immunobiology : the immune system in health and disease; Charles A. Janeway, Jr. et al.; 5th ed.; 2001 3. Parkin J, Cohen B. An Overview of the Immune System. Lancet. 2001;357:1777-89

Phn 2: Tng quan v Vc xin hc

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Min dch ch ng v th ng

Min dch t nhin

Min dch nhn to

Ch ng

Th ng

Th ng

Ch ng

Sau nhim trng

Nhn khng th qua nhau thai

Tim trc tip khng th

Phi nhim vi khng th

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Peter G. Immunization Practices. In: Behrman RE, Kliegman RM & Jenson HB eds. Nelsons Textbook of Pediatrics. WB Saunders Company; 2000 3. General Properties of Immune Responses. In: Abbas AK, Lichtman AH, Pober JS. eds. Cellular & Molecular Immunology. WB Saunders Company; 1994

S min dch th ng (Immunization)

Immunoglobulins c truyn cho ngi khng c min dch

Immunoglobin c ly t ngi c min dch

Ngi hin (i tng c MD)

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

i tng c nhn MD th ng
1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Peter G. Immunization Practices. In: Behrman RE, Kliegman RM & Jenson HB eds. Nelsons Textbook of Pediatrics. WB Saunders Company; 2000 3. General Properties of Immune Responses. In: Abbas AK, Lichtman AH, Pober JS. eds. Cellular & Molecular Immunology. WB Saunders Company; 1994

S min dch th ng
Hn ch:

Hm lng khng th

Thi gian bo v ngn Chi ph

S an ton

4 Tim Ig

12

16

20

Tun

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Peter G. Immunization Practices. In: Behrman RE, Kliegman RM & Jenson HB eds. Nelsons Textbook of Pediatrics. WB Saunders Company; 2000 3. General Properties of Immune Responses. In: Abbas AK, Lichtman AH, Pober JS. eds. Cellular & Molecular Immunology. WB Saunders Company; 1994

Min dch ch ng - Chng nga (Vaccination)

Khng nguyn (vaccine) c a vo i tng cha c MD

Ngi c to MD (Cha c MD) ch ng

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011
1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Peter G. Immunization Practices. In: Behrman RE, Kliegman RM & Jenson HB eds. Nelsons Textbook of Pediatrics. WB Saunders Company; 2000 3. General Properties of Immune Responses. In: Abbas AK, Lichtman AH, Pober JS. eds. Cellular & Molecular Immunology. WB Saunders Company; 1994

Ngi nhn

Chng nga
u im:
Hm lng khng th

Bo v lu di Kinh t An ton

4
Chng nga

12

16

20

Tun

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Cc c tnh ca vc xin
Mt vc xin l tng:

C tnh sinh min dch

Bt chc nhim trng t nhin Vi khong cch di gia cc liu nhc (cng c)

Cho s bo v ko di

t sinh phn ng khng mong mun

Bn vng

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Li ch ca chng nga
Bo v tng cc c th Bo v cng ng

Min dch cng ng -herd protection

Li ch kinh t khng l

C th xa s bnh tt

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Li ch ca chng nga
Polio - worldwide
Reported cases (000s) 60 40 EPI implemented 20 Vaccine introduced

Measles - US

1980

1990

2000

1950

1960

1970

1980

1990

2000

Diphtheria England & Wales

Reported cases (000s) 60 40 Vaccine introduced 20

1940
Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

1960

1980

2000

Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. 2008

Vit nam: Li ch chng nga trong gim t l bnh

S ca Ho g

Din dn Min dch hc v chng nga dnh cho CBYT. Unicef. National EPI Report Vietnam, 2009. http://www.unicef.org/vietnam/EPI_NATIONAL_Review_Report_Vietnam_2009_Final.pdf Tp.HCM 23/7/2011

Phn loi Vc xin

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Cc loi vc xin
Vc xin vi rt
Sng, gim c lc Cht, bt hot Tiu n v

Vc xin vi khun
Ton t bo Bin c t Tiu n v polysaccharide

Vc xin phi hp

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Vc xin sng gim c lc

Pht trin t mt chng c lm yu i
Chng vi rt hoang di c nhn i trong iu kin mi trng khng thun li

Qu trnh ny c lp li nhiu ln

sn xut chng b lm yu i sao cho kh nng gy bnh b mt i

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011
1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Vc xin sng gim c lc (tt)

Sn xut vc xin
Vi rt t Master Working Cell Bank

c nhn sinh trn din rng...

sau c thu hoch, kim tra v sn xut thnh vc xin

1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Vc xin cht, bt hot

Sn xut vc xin
Vi rt c nui trong mi trng thun li c lc sch v c x l bng nhit hoc ha cht nhm lm chtbt hot vi rt nhng vn bo ton tnh sinh min dch
Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011
1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Vc xin cht, bt hot

Li im:
t sinh phn ng Khng c nguy c gy bnh Thng bn vng hn vi nhit

Nhc im:
Thng t hiu qu hn so vi vc xin sng gim c lc Cn chng vi ln t hiu qu

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Vc xin vi rt tiu n v

Influenza virus c nui trong mi trng ph hp dng solvents chia ct v cc thnh phn khng nguyn c tinh lc
1. Vaccines. In: Kuby J. Immunology. New York: WH Freeman & Co; 2004 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Vc xin vi rt tiu n v
Vc xin ti t hp

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

1. Technologies for Making New Vaccines. In: Plotkin SA, Orenstein WA, eds. Vaccines. Saunders; 2004. p1185 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Vc xin vi rt tiu n v
Vc xin ti t hp

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

1. Technologies for Making New Vaccines. In: Plotkin SA, Orenstein WA, eds. Vaccines. Saunders; 2004. p1185 2. Principles of Vaccination. In: Atkinson W, Hamborsky J, McIntyre L, Wolfe C, eds. CDC. Epidemiology & Prevention of Vaccine Preventable Diseases. Washington DC: Public Health Foundation; 2006

Cht b tr
p ng i vi KN + cht b tr

Hm lng khng th

p ng vi mt mnh KN

10

Tun

Chng nga
1.WHO website. Global Advisory Committee on Vaccine Safety; Adjuvants. http://www.who.int/vaccine_safety/topics/adjuvants/en/index.html 2. Petrovsky N,Aguilar JC. Vaccine Adjuvants: Current Sate and Future Trends. Immunol Cell Biol. 2004;82:488-96

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Kt lun
H min dch rt phc tp. Cc t bo min dch tng tc cht ch vi nhau loi tr cc thnh phn ngoi lai (Khng nguyn) ra khi c th. Tn ti cc c ch hot ng min dch khc nhau:
Min dch bm sinh & mc phi (qua trung gian khng th v qua trung gian t bo. Min dch t nhin & nhn to. Min dch th ng & min dch ch ng.

Hiu bit v hot ng ca min dch l rt cn thit hiu c c ch tc ng ca vc xin trong phng nga bnh tt v nn tng ca cc khuyn co cho s dng vc xin.
Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011

Xin chn thnh cm n!

Din dn Min dch hc v chng nga dnh cho CBYT. Tp.HCM 23/7/2011