Gii thiu v Morphine

Cu trc Tnh cht ca Morphine

Hot tnh sinh hc Cng dng
I
2
3
TM HIU HP CHT MORPHINE-
1. GII THIU V MORPHINE
Morphine l mt alcaloit c hm lng cao nht
(10%) trong nha kh qu cy thuc phin.

Mc ch yu cc vng kh hu mt.

nc ta thng gieo ht vo cui thng 10 u
thng 11 v thu hoch vo cui thng 3 u thng
4.

Morphin tn ti trong thuc phin di dng mui
tan trong nc.
2. CU TRC TNH CHT
CTPT: C
17
H
19
N0
3

CTCT:
Tn gi: (5,6)-7,8-
didehydro-4,5-epoxy-
17-methyl morphinan-
3,6-diol


NG PHN
C IM CU TRC

Trong cu trc ca
morphin, phn chnh quyt
nh tc dng dc l ca
morphin l nhn thm,
nhn piperidin v lin kt
ba carbon ni gia nhn
thm v chc amin bc 3

TNH CHT L - HA
- Morphin c nhit nng chy 2300C, t tan
trong nc.

- Morphin c nhm OH ca phenol nn tan
trong dung dch nc c tnh cht kim v
khng tan trong dung mi hu c.


TNH CHT L - HA
- Tc dng vi dinitrofluobenzen to kt ta
morphindinitrophenylete:
TNH CHT L - HA
Tc dng vi HNO
2
cho ra 2-nitrosomorphin:
3. HOT TNH SINH HC
Morphin tc dng ln thn kinh trung ng nht l
v no, c ch trung b au gy ng thng qua hot
tnh hot ha hoc c ch cc receptor ca c th.

Morphin c th trc tip gy gii phng histamin, do
lm gin mch ngoi vi t ngt, nh da, thm
ch gy co tht ph qun.


HOT TNH SINH HC
Morphin c xp vo thuc c bng A gy
nghin.

Morphin c ch h hp l do tc dng c ch ca
CO2 trn trung tm h hp hnh no.

Morphin lm tng gii phng hormon chng bi
niu, lm gim lng nc tiu.

CM N THY V CC BN
LNG NGHE