www.DiabetesHealth.

com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH

www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH
Insulin Manufacturer
Onset
(approximately)
Peak
(approximately)
Duration
(approximately)
Room Temperature
Storage Range (5986 F)
Need to Roll
Briskly 10+
Times?
Cartridge
Sizes
Pens That Fit
the Cartridges
R
A
P
I
D

A
C
T
I
N
G
Apidra
(insulin glulisine [rDNA origin] injection)
sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Apidra SoloSTAR
(preflled)
sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Apidra Cartridge sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No 3 mL OptiClik
Humalog Vial
(insulin lispro)
Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Humalog Cartridge Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No 3 mL Autopen
Humalog Pen
(preflled)
Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less
Up to 28 days

c
No N/A N/A
NovoLog Vial
(insulin aspart)
Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No N/A N/A
NovoLog PenFill Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No 3 mL NovoPen 3, NovoPen Junior
NovoLog FlexPen
(preflled)
Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No 3 mL N/A
S
H
O
R
T

A
C
T
I
N
G
Humulin R (Regular) Vial
a
Eli Lilly & Company 3060 minutes 24 hours 58 hours Up to 28 days No N/A N/A
Novolin R Vial
(Regular human insulin)
Novo Nordisk 30 minutes 80120 minutes 8 hours N/A No N/A N/A
ReliOn/Novolin R Vial Novo Nordisk 30 minutes 80120 minutes 8 hours Up to 42 days No N/A N/A
I
N
T
E
R
M
E
D
I
A
T
E

A
C
T
I
N
G
Humulin N (NPH) Vial Eli Lilly & Company 12 hours 28 hours 1424 hours Up to 28 days Yes N/A N/A
Humulin N (NPH) Pen
(preflled)
Eli Lilly & Company 12 hours 28 hours 1424 hours
Up to 14 days
c
Yes N/A N/A
Novolin N PenFill
(NPH human insulin isophane)
Novo Nordisk 1.5 hours 412 hours 24 hours 14 days Yes 3 mL NovoPen3, NovoPen Junior
Novolin N Vial
(NPH human insulin isophane)
Novo Nordisk 1.5 hours 412 hours 24 hours Up to 42 days Yes N/A N/A
ReliOn/Novolin N Vial Novo Nordisk 1.5 hours 412 hours 24 hours Up to 42 days Yes N/A N/A
All insulins listed are U-100 strength. All insulins should be refrigerated at 3646 F.
a: Also available in U-500 by prescription only.
b: Lantus and Levemir release at a relatively constant rate over a 24-hour period.
c: Pens in use (open) should not be stored in the refrigerator.
Apidra
Humulin N Pen
Insulin
NovoLog
Humalog
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH
Insulin Manufacturer
Onset
(approximately)
Peak
(approximately)
Duration
(approximately)
Room Temperature
Storage Range (5986 F)
Need to Roll
Briskly 10+
Times?
Cartridge
Sizes
Pens That Fit
the Cartridges
R
A
P
I
D

A
C
T
I
N
G
Apidra
(insulin glulisine [rDNA origin] injection)
sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Apidra SoloSTAR
(preflled)
sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Apidra Cartridge sanof-aventis 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No 3 mL OptiClik
Humalog Vial
(insulin lispro)
Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No N/A N/A
Humalog Cartridge Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less Up to 28 days No 3 mL Autopen
Humalog Pen
(preflled)
Eli Lilly & Company 1530 minutes 0.52.5 hours 5 hours or less
Up to 28 days

c
No N/A N/A
NovoLog Vial
(insulin aspart)
Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No N/A N/A
NovoLog PenFill Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No 3 mL NovoPen 3, NovoPen Junior
NovoLog FlexPen
(preflled)
Novo Nordisk 1020 minutes 13 hours 35 hours Up to 28 days No 3 mL N/A
S
H
O
R
T

A
C
T
I
N
G
Humulin R (Regular) Vial
a
Eli Lilly & Company 3060 minutes 24 hours 58 hours Up to 28 days No N/A N/A
Novolin R Vial
(Regular human insulin)
Novo Nordisk 30 minutes 80120 minutes 8 hours N/A No N/A N/A
ReliOn/Novolin R Vial Novo Nordisk 30 minutes 80120 minutes 8 hours Up to 42 days No N/A N/A
I
N
T
E
R
M
E
D
I
A
T
E

A
C
T
I
N
G
Humulin N (NPH) Vial Eli Lilly & Company 12 hours 28 hours 1424 hours Up to 28 days Yes N/A N/A
Humulin N (NPH) Pen
(preflled)
Eli Lilly & Company 12 hours 28 hours 1424 hours
Up to 14 days
c
Yes N/A N/A
Novolin N PenFill
(NPH human insulin isophane)
Novo Nordisk 1.5 hours 412 hours 24 hours 14 days Yes 3 mL NovoPen3, NovoPen Junior
Novolin N Vial
(NPH human insulin isophane)
Novo Nordisk 1.5 hours 412 hours 24 hours Up to 42 days Yes N/A N/A
ReliOn/Novolin N Vial Novo Nordisk 1.5 hours 412 hours 24 hours Up to 42 days Yes N/A N/A
AMYLIN MIMETIC
Amylin is co-secreted in the beta cells of the
pancreas along with insulin. Its a frst-in-class
injectable medication used with mealtime insulin
to control blood sugar in adults with type 1 or
type 2 diabetes.
SYMLIN
(pramlintide acetate) injection
SYMLINPEN
TM

(pramlintide acetate) pen-injector
Amylin Pharmaceuticals, Inc.
The amount of SYMLIN used depends on
whether the patient has type 1 or type 2
diabetes.
* For type 2 diabetes - start SYMLIN at 60 mcg
injected subcutaneously, just before major
meals (meal must have at least 250 calories or
30 grams of carbohydrate).
* For type 1 diabetes - start SYMLIN at 15 mcg
injected subcutaneously, just before major
meals (meal must have at least 250 calories or
30 grams of carbohydrate).
Type 2: 120 mcg
Type 1: 60 mcg with major meals
Insulin-induced low blood sugar (severe
hypoglycemia): Low blood sugar is a serious side
efect of insulin therapy. When you use Symlin
and insulin, your blood sugar may drop too low,
especially if you have type 1 diabetes. If this low
blood sugar (severe hypoglycemia) happens, it is
seen within three hours after a Symlin injection.
Severe low blood sugar makes it hard to think
clearly, drive a car, use heavy machinery, or
do other risky activities where you could hurt
yourself or others.
When you frst start Symlin, your healthcare
professional should tell you to reduce the dose
of insulin you take before meals by 50 percent.
Future insulin changes should be directed by
your healthcare professional based on blood
sugar testing. It is critical to the safe and
efective use of Symlin that you understand your
healthcare professionals instructions, follow
them carefully, and take your Symlin exactly as
prescribed.
Nausea is the most common side efect of
Symlin. Mild nausea is more likely during the
frst weeks after starting Symlin and usually
does not last long. Talk to your healthcare
professional for advice on how to manage
nausea.
Customer Support: Eli Lilly & Co. (800) 545-5979
Novo Nordisk (800) 727-6500
sanof-aventis (800) 633-1610
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH
Insulin Manufacturer
Onset
(approximately)
Peak
(approximately)
Duration
(approximately)
Room Temperature
Storage Range (5986 F)
Need to Roll
Briskly 10+ Times?
Cartridge
Sizes
Pens That Fit
the Cartridges
L
O
N
G

A
C
T
I
N
G
Lantus Vial
(insulin glargine [rDNA origin] injection)
sanof-aventis 1.5 hours None

b
24 hours Up to 28 days No N/A N/A
Lantus Cartridge sanof-aventis 1.5 hours None
b
24 hours Up to 28 days No 3 mL OptiClik
Lantus SoloSTAR
(preflled)
sanof-aventis 1.5 hours None 24 hours Up to 28 days No N/A N/A
Levemir Vial
(insulin detemir [rDNA origin] injection)
Novo Nordisk 50120 minutes Relatively fat Up to 24 hours Up to 42 days No N/A N/A
Levemir FlexPen
(insulin detemir [rDNA origin] injection)
Novo Nordisk 50120 minutes Relatively fat Up to 24 hours Up to 42 days No 3 mL N/A
I
N
T
E
R
M
E
D
I
A
T
E
/
R
A
P
I
D

A
C
T
I
N
G
Humalog Mix 75/25 Vial Eli Lilly & Company 1530 minutes 0.52.5 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humalog Mix 75/25 Pen (preflled) Eli Lilly & Company 1530 minutes 0.52.5 hours Up to 24 hours
Up to 10 days
c
Yes N/A N/A
NovoLog Mix 70/30 Vial
(70% insulin aspart protamine suspension/30% aspart)
Novo Nordisk 1020 minutes 2.4 hours Up to 24 hours Up to 28 days Yes N/A N/A
NovoLog Mix 70/30 FlexPen Novo Nordisk 1020 minutes 2.4 hours Up to 24 hours Up to 14 days Yes 3 mL N/A
I
N
T
E
R
M
E
D
I
A
T
E
/
S
H
O
R
T

A
C
T
I
N
G
Humulin 50/50 Vial (50% NPH/50% Regular) Eli Lilly & Company 3060 minutes 0.52.5 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humulin 70/30 Vial (70% NPH/30% Regular) Eli Lilly & Company 3060 minutes 0.55 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humulin 70/30 Pen (preflled) Eli Lilly & Company 3060 minutes 24 hours Up to 24 hours Up to 10 days Yes N/A N/A
Novolin 70/30 Vial (70% NPH/30% Regular) Novo Nordisk 30 minutes 212 hours 24 hours Up to 42 days Yes N/A N/A
ReliOn/Novolin 70/30 Vial Novo Nordisk 30 minutes 2-12 hours 24 hours Up to 42 days Yes N/A N/A
Humulin 70/30 Pen
Lantus
Insulin
All insulins listed are U-100 strength. All insulins should be refrigerated at 3646 F.
a: Also available in U-500 by prescription only.
b: Lantus and Levemir release at a relatively constant rate over a 24-hour period.
c: Pens in use (open) should not be stored in the refrigerator.
NovoLog Mix
70/30 FlexPen
Lantus
Levemir
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH
Insulin Manufacturer
Onset
(approximately)
Peak
(approximately)
Duration
(approximately)
Room Temperature
Storage Range (5986 F)
Need to Roll
Briskly 10+ Times?
Cartridge
Sizes
Pens That Fit
the Cartridges
L
O
N
G

A
C
T
I
N
G
Lantus Vial
(insulin glargine [rDNA origin] injection)
sanof-aventis 1.5 hours None

b
24 hours Up to 28 days No N/A N/A
Lantus Cartridge sanof-aventis 1.5 hours None
b
24 hours Up to 28 days No 3 mL OptiClik
Lantus SoloSTAR
(preflled)
sanof-aventis 1.5 hours None 24 hours Up to 28 days No N/A N/A
Levemir Vial
(insulin detemir [rDNA origin] injection)
Novo Nordisk 50120 minutes Relatively fat Up to 24 hours Up to 42 days No N/A N/A
Levemir FlexPen
(insulin detemir [rDNA origin] injection)
Novo Nordisk 50120 minutes Relatively fat Up to 24 hours Up to 42 days No 3 mL N/A
I
N
T
E
R
M
E
D
I
A
T
E
/
R
A
P
I
D

A
C
T
I
N
G
Humalog Mix 75/25 Vial Eli Lilly & Company 1530 minutes 0.52.5 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humalog Mix 75/25 Pen (preflled) Eli Lilly & Company 1530 minutes 0.52.5 hours Up to 24 hours
Up to 10 days
c
Yes N/A N/A
NovoLog Mix 70/30 Vial
(70% insulin aspart protamine suspension/30% aspart)
Novo Nordisk 1020 minutes 2.4 hours Up to 24 hours Up to 28 days Yes N/A N/A
NovoLog Mix 70/30 FlexPen Novo Nordisk 1020 minutes 2.4 hours Up to 24 hours Up to 14 days Yes 3 mL N/A
I
N
T
E
R
M
E
D
I
A
T
E
/
S
H
O
R
T

A
C
T
I
N
G
Humulin 50/50 Vial (50% NPH/50% Regular) Eli Lilly & Company 3060 minutes 0.52.5 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humulin 70/30 Vial (70% NPH/30% Regular) Eli Lilly & Company 3060 minutes 0.55 hours Up to 24 hours Up to 28 days Yes N/A N/A
Humulin 70/30 Pen (preflled) Eli Lilly & Company 3060 minutes 24 hours Up to 24 hours Up to 10 days Yes N/A N/A
Novolin 70/30 Vial (70% NPH/30% Regular) Novo Nordisk 30 minutes 212 hours 24 hours Up to 42 days Yes N/A N/A
ReliOn/Novolin 70/30 Vial Novo Nordisk 30 minutes 2-12 hours 24 hours Up to 42 days Yes N/A N/A
Customer Support: Eli Lilly & Co. (800) 545-5979
Novo Nordisk (800) 727-6500
sanof-aventis (800) 633-1610