Sub RemDupes2()

Dim ColN As Long

Dim MyS As Worksheet: Set MyS = ActiveSheet
Dim MyR As Range: Set MyR = MyS.Cells(1, 1).CurrentRegion
Dim NumCol As Long: NumCol = MyR.Columns.Count
Dim MyArray As Variant: ReDim MyArray(0 To NumCol - 1)
For ColN = 1 To NumCol
MyArray(ColN - 1) = ColN
Next
MyR.RemoveDuplicates Columns:=(MyArray), Header:=xlYes
End Sub
Source: MrEXCEL