Healthy sleep will typically progress through the four stages of
NREM sleep prior to the first REM period. From wakefulness, sleep typically progresses quickly through stages 1 and 2. During stages 3 and 4 NREM , both metabolic activity and brain waves slow. This slow waves sleep occurs most frequently early in the sleep cycle. After stages 4, the first REM cycles tend to lengthen in the later stages of the sleep cycle. REM sleep involves a dramatic physiological change from stage NREM slow wave sleep, to a state in which the brain becomes electrically and metabolically actived. REM occurs in bursts, and is accompanied by a 62% to 173% increase in cerebral flow generalized muscle atonia, poikilothermia, vivid dreaming, and fluctuation in respiratory and cardiac rate.