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Am J Geriatr Psychiatry. 2014 Apr 26. pii: S1064-7481(14)00136-5. doi: 10.1016/j.jagp.2014.04.006. [Epub
ahead of print]
Alcohol Consumption Patterns and Cognitive
Impairment in Older Women.
Hoang TD , Byers AL , Barnes DE , Yaffe K .
Abstract
Few studies have investigated changes in alcohol consumption and risk of
cognitive impairment among oldest old adults.
In a prospective study of 1309 women !65 years old, alcohol use was assessed
at repeated visits and used to estimate average change in alcohol consumption over 16
years. Clinically significant cognitive impairment (mild cognitive impairment and dementia)
was assessed at year 20.
Compared with the reference group (slight decrease in alcohol consumption by
0-0.5 drinks/week, 60.4%), increasing consumption over time (>0 drinks/week) was not
associated with risk of cognitive impairment (5.0%, odds ratio [OR]: 1.00, 95% confidence
interval [CI]: 0.54-1.85). Decreasing consumption by >0.5 drinks/week was associated with
increased risk (34.5%, OR: 1.34, 95% CI: 1.05-1.70). Adjustment for age, education, diabetes,
smoking, BMI, and physical activity attenuated the magnitude of the effect slightly and
resulted in borderline statistical significance.
Women in their ninth and tenth decade of life who decrease alcohol use may
be at risk of cognitive impairment.
Copyright 2014 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All
rights reserved.
Cognitive impairment; alcohol; dementia
PMID: 24862680 [PubMed - as supplied by publisher]
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Alcohol Consumption Patterns and Cog... [Am J Geriatr Psych... http://www.ncbi.nlm.nih.gov/pubmed/24862680
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Alcohol Consumption Patterns and Cog... [Am J Geriatr Psych... http://www.ncbi.nlm.nih.gov/pubmed/24862680
2 de 2 12/06/14 06:53