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Rheumatology Inflammatory

RheumatoidArthritis
Chronic systemic inflammatory disease
Symmetrical, deformingperipheral polyarthritis
Higher prevalance infemales; typicallyfrom30s
Does not affect DIP joints
Acute flares superimposedover moderate progression
Extra articular signs
Nodules onelbows
Worse inthe morning
Spondyloarthritides / Seronegative
Ankylosing Spondylitis
Chronic inflammationof spine and
sacroiliac joints
Presentation: <30years old, gradual
onset lowbackpain, worse at night,
spinal morningstiffness relievedby
exercise
Progressive loss of spinal movement
Enteropathic
AssociatedwithCrohn's / UC
Also assoicatedwithcoeliac
Psoriatic Arthritis
Occurs withpsoriasis, althoughcan
present before skinchanges
Canpresent as oligoarthritis (<5joints) or
polyarthritis (>5joints)
Reactive Arthritis
Sterile arthritis typicallyaffectinglower limb
Oftenfollows urethritis andcanpresent
withsystemic features
Autoimmune Systemic Lupus Erythematosus
Systemic conditionwhere autoantibodies
are producedagainst a variety of
autoantigens
Typicallywomenof childbearingage
Relaspingandremitting
Polyarthritis
Septic Arthritis
Typically monoarthritis
Analgesia, bloodcultures, synovial fluid,
empirical antibiotics until sensitivities
known
Needto treat ASAP or riskof permanent
joint damage or septicaemia
One or two joints, single acute episode
Crystal Arthropathies
Gout
Severe joint pain, redness andswelling
Typicallymonoarthritis, oftenthe bigtoe
Depositionof urate crystals
Associatedwithtrauma, surgery,
starvation, infection, diuretics and
alcoholism
Treatment
Acute: NSAIDs and colchicine
Chronic prevention: allopurinol
A number of acute episodes affectingone joint
Pseudo Gout
Similar presentationto gout
Typically monoarthritis
Osteoarthritis
Commonest joint condition, more commoninwomen
Slowprogression, mayplateauover time
Localiseddisease
Usuallyknee or hip
Pain/ crepitus onmovement
Worse at night
Generaliseddisease
Heberden's nodes
Commonlyaffect DIP, thumb
carpo-metacarpal joints andthe knee
Classic X-rayfeatures
Loss of joint space
Subchondral sclerosis
and cysts
Marginal osteophytes
Management
Painrelief
Quadriceps exercise
Reduce weight
Intra-articular steroidinjections
J oint replacement
Rheumatology.mmap - 12/10/2009 -

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