Surname 1

Name
Professor
Course
Date
Neurology
1) The cellular mechanism that leads to the generation of epilepsy in humans and animals is
associated with Cortical spreading depression (CSD), which is molecular disruptions in
small neurons known as granules The granules are located in the dentate gyros region of
the !rain that generates migraine aura and there!y causes headache pains in these mice
Some pains can also !e caused !y the shortage of synapsin
") # secreted protein in humans is contained in !rain$deri%ed neurotrophic gene This
protein is known as &rain$deri%ed neurotrophic factor (&DN') (t helps to support the
sur%i%al of the e)isting neurons and encourage the growth and differentiation of new
neurons and synapses The &DN' !inds some receptors on the surface of cells that then
respond to this growth factor *i%en &DN'+s role in the de%elopment of the !rain, there is
a lot of influence on the de%elopment of neuropathologies from &DN'
,) The deletion of -a!,a results in glutamatergic synapses that ha%e a compromised
sensiti%ity to either low .$#P concentration or prominent e)tracellular The changes
mitigate the o%ere)cita!le phenotype, thus the deletion appears to !ring !ack the
inhi!itory/e)citatory im!alance !ecause of impairing e)citatory glutamatergic synaptic
transmission