1. Int J Pharm. 2009 Jun 22;375(1-2):67-74. doi: 10.1016/j.ijpharm.2009.04.016.

Epub
2009 Apr 19.
Improved properties of incorporated chitosan film with ethyl cellulose
microspheres for controlled release.
Shi P(1), Zuo Y, Zou Q, Shen J, Zhang L, Li Y, Morsi YS.
Author information:
(1)The Research Center for Nano Biomaterials, Analytical and Testing Center, Sic
huan
University, Chengdu 610064, China.
In this article, to discover an innovative drug release system, ciprofloxacin
hydrochloride-loaded blending films of chitosan (CS)/ethyl cellulose (EC)
microspheres were prepared. Two steps were adopted in the film forming process.
The first was formation of the drug-loaded EC microspheres in CS solution by
solvent remove/solvent evaporation methods; then, the composite films were made
by casting and solvent evaporation. The results were that the drug-loaded round
EC microspheres dispersed asymmetrically in the CS films and largely improved th
e
release time. Moreover, the drug-loaded blending film containing 0.5 g EC
microspheres prepared at 90 degrees C showed highlighted extended release
property. The drug was stable in the blending films, which expressed good
cytocompatibility proved by MTT test. The film should be a promising carrier for

controlled and extended drug release system in pharmaceutical applications.
PMID: 19383531 [PubMed - indexed for MEDLINE]